Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03218:Zfp759'

413554

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp759

Ensembl Gene

ENSMUSG00000057396

Gene Name

zinc finger protein 759

Synonyms

Rslcan-8

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL03218

Quality Score

Status

Chromosome

Chromosomal Location

67121660-67141787 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 67139416 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 344 (V344L)

Ref Sequence

ENSEMBL: ENSMUSP00000049650 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052716] [ENSMUST00000224346]

Predicted Effect

probably benign
Transcript: ENSMUST00000052716
AA Change: V344L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000049650
Gene: ENSMUSG00000057396
AA Change: V344L

Domain	Start	End	E-Value	Type
KRAB	5	65	1.6e-22	SMART
ZnF_C2H2	106	128	5.54e1	SMART
ZnF_C2H2	162	184	3.83e-2	SMART
ZnF_C2H2	190	212	1.82e-3	SMART
ZnF_C2H2	218	240	1.64e-1	SMART
ZnF_C2H2	246	268	1.67e-2	SMART
ZnF_C2H2	274	296	1.95e-3	SMART
ZnF_C2H2	302	324	1.84e-4	SMART
ZnF_C2H2	330	352	7.78e-3	SMART
ZnF_C2H2	358	380	1.6e-4	SMART
ZnF_C2H2	386	408	1.67e-2	SMART
ZnF_C2H2	414	436	4.87e-4	SMART
ZnF_C2H2	442	464	3.39e-3	SMART
ZnF_C2H2	498	520	2.57e-3	SMART
ZnF_C2H2	526	548	8.47e-4	SMART
ZnF_C2H2	554	576	2.02e-1	SMART
ZnF_C2H2	582	604	2.53e-2	SMART
ZnF_C2H2	610	632	4.79e-3	SMART
ZnF_C2H2	638	660	1.84e-4	SMART
ZnF_C2H2	666	688	1.36e-2	SMART
ZnF_C2H2	694	716	4.17e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223605

Predicted Effect

probably benign
Transcript: ENSMUST00000224346

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224426

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aacs	T	C	5: 125,484,663		probably null	Het
Acot9	T	A	X: 155,295,211	V251E	possibly damaging	Het
Agtpbp1	A	G	13: 59,500,207	S600P	possibly damaging	Het
Amfr	A	T	8: 94,000,336	M157K	probably damaging	Het
Arvcf	T	C	16: 18,404,125		probably benign	Het
Ascc3	T	C	10: 50,823,853	V1924A	possibly damaging	Het
Atp10a	T	A	7: 58,788,448		probably null	Het
Atp1a2	T	A	1: 172,289,303	E249V	probably null	Het
C1qc	A	G	4: 136,890,287	L166P	probably damaging	Het
Col4a3	C	A	1: 82,643,206		probably benign	Het
Def8	A	G	8: 123,456,436	D258G	probably damaging	Het
Dll1	T	C	17: 15,373,568	D179G	probably benign	Het
Dnah14	C	A	1: 181,755,269	H3124Q	probably benign	Het
Fabp5	T	A	3: 10,014,963		probably benign	Het
Fam133b	C	T	5: 3,554,684	Q24*	probably null	Het
Fam13c	A	C	10: 70,448,769	D25A	possibly damaging	Het
Flna	A	G	X: 74,234,602		probably null	Het
Frem1	T	A	4: 82,914,646	T1917S	probably benign	Het
Frmd4b	T	C	6: 97,308,114	T337A	probably benign	Het
Fxyd7	C	T	7: 31,044,570		probably null	Het
Galnt5	T	G	2: 57,999,389	S334A	possibly damaging	Het
Gm10220	T	C	5: 26,118,698	K117R	probably damaging	Het
Gpd2	T	A	2: 57,307,054	L207H	probably damaging	Het
H2-M10.3	T	A	17: 36,367,387	Y182F	probably damaging	Het
Itga8	T	C	2: 12,111,025	I1018V	possibly damaging	Het
Letmd1	T	C	15: 100,469,828	F89S	probably damaging	Het
Mcm3ap	A	G	10: 76,482,733	Y696C	probably damaging	Het
Mcpt9	A	G	14: 56,027,451	Y198H	probably damaging	Het
Mmp1b	A	G	9: 7,387,907	V29A	probably benign	Het
Myom1	A	G	17: 71,084,316	D940G	possibly damaging	Het
Myzap	A	G	9: 71,555,589	M225T	probably benign	Het
Naa25	A	G	5: 121,426,070	Y516C	probably damaging	Het
Nsdhl	T	A	X: 72,956,446		probably benign	Het
Olfml1	A	G	7: 107,571,269	E121G	possibly damaging	Het
Olfr1085	A	G	2: 86,658,359	I33T	probably benign	Het
Olfr1245	A	G	2: 89,575,591	V45A	probably benign	Het
Olfr736	A	T	14: 50,393,658	M301L	probably damaging	Het
Phex	C	T	X: 157,178,787	G636E	probably damaging	Het
Pkd2l2	A	T	18: 34,430,320	I475F	probably damaging	Het
Polr2b	T	A	5: 77,315,917	S54T	probably benign	Het
Prkx	A	T	X: 77,786,200	L85Q	probably damaging	Het
Smc1b	A	T	15: 85,089,713	I914N	probably benign	Het
Susd2	A	G	10: 75,642,625	L39P	probably benign	Het
Teddm2	C	T	1: 153,851,024	V35I	probably benign	Het
Tspo	T	A	15: 83,571,430	V6E	possibly damaging	Het
Vps41	G	T	13: 18,829,270	V353F	possibly damaging	Het
Wfdc18	T	A	11: 83,709,207		probably null	Het
Wsb1	C	T	11: 79,248,498	S124N	probably damaging	Het
Zfp445	T	C	9: 122,857,529	E177G	probably benign	Het

Other mutations in Zfp759

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01509:Zfp759	APN	13	67139594	missense	probably benign	0.25
IGL03131:Zfp759	APN	13	67138664	missense	probably damaging	1.00
R0243:Zfp759	UTSW	13	67138813	missense	possibly damaging	0.66
R0319:Zfp759	UTSW	13	67140292	missense	probably benign	0.00
R0520:Zfp759	UTSW	13	67137355	missense	probably benign	0.29
R0961:Zfp759	UTSW	13	67139863	missense	probably benign	0.32
R1435:Zfp759	UTSW	13	67138766	missense	possibly damaging	0.73
R1649:Zfp759	UTSW	13	67139604	missense	probably benign	0.00
R1880:Zfp759	UTSW	13	67139212	missense	probably damaging	1.00
R2118:Zfp759	UTSW	13	67139514	unclassified	probably benign
R2170:Zfp759	UTSW	13	67136748	missense	possibly damaging	0.88
R3154:Zfp759	UTSW	13	67138655	missense	probably benign	0.20
R3551:Zfp759	UTSW	13	67138967	missense	probably benign	0.24
R4392:Zfp759	UTSW	13	67139643	nonsense	probably null
R4495:Zfp759	UTSW	13	67138925	unclassified	probably null
R4736:Zfp759	UTSW	13	67139344	missense	probably damaging	1.00
R4882:Zfp759	UTSW	13	67139290	missense	probably damaging	1.00
R5717:Zfp759	UTSW	13	67138708	missense	probably damaging	1.00
R5921:Zfp759	UTSW	13	67140494	missense	probably damaging	1.00
R6247:Zfp759	UTSW	13	67140460	missense	probably benign	0.00
R6381:Zfp759	UTSW	13	67138905	nonsense	probably null
R6427:Zfp759	UTSW	13	67139098	unclassified	probably null
R6567:Zfp759	UTSW	13	67139086	missense	probably benign	0.34
R7140:Zfp759	UTSW	13	67140113	missense	possibly damaging	0.92

Posted On

2016-08-02