Incidental Mutation 'IGL03224:Cyp4a29'
| ID |
413737 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Cyp4a29
|
| Ensembl Gene |
ENSMUSG00000083138 |
| Gene Name |
cytochrome P450, family 4, subfamily a, polypeptide 29 |
| Synonyms |
Cyp4a29-ps |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.067)
|
| Stock # |
IGL03224
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
115099281-115111754 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 115104247 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 105
(M105K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139717
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000118278]
|
| AlphaFold |
A0A087WPC3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000118278
AA Change: M105K
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000139717
Gene: ENSMUSG00000083138
AA Change: M105K
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
9 |
31 |
N/A |
INTRINSIC |
|
Pfam:p450
|
51 |
504 |
1.1e-127 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ash1l |
T |
C |
3: 88,942,575 (GRCm39) |
|
probably benign |
Het |
| Capn10 |
T |
G |
1: 92,867,046 (GRCm39) |
V92G |
probably damaging |
Het |
| Cntn2 |
A |
G |
1: 132,450,780 (GRCm39) |
C532R |
probably damaging |
Het |
| Csf1r |
T |
C |
18: 61,245,134 (GRCm39) |
F233L |
probably damaging |
Het |
| Cts6 |
T |
C |
13: 61,349,547 (GRCm39) |
D82G |
probably damaging |
Het |
| Cym |
T |
C |
3: 107,126,048 (GRCm39) |
S72G |
possibly damaging |
Het |
| Dhx35 |
T |
C |
2: 158,699,052 (GRCm39) |
|
probably benign |
Het |
| Dnah5 |
C |
A |
15: 28,459,300 (GRCm39) |
D4506E |
probably damaging |
Het |
| Dok5 |
T |
C |
2: 170,674,807 (GRCm39) |
F139L |
possibly damaging |
Het |
| Dync2h1 |
T |
C |
9: 7,076,235 (GRCm39) |
D2974G |
probably benign |
Het |
| Frem3 |
C |
T |
8: 81,340,092 (GRCm39) |
T795I |
probably damaging |
Het |
| Ints6l |
A |
G |
X: 55,543,287 (GRCm39) |
T525A |
probably damaging |
Het |
| Lrp1b |
T |
C |
2: 41,361,043 (GRCm39) |
T587A |
possibly damaging |
Het |
| Meikin |
A |
G |
11: 54,289,286 (GRCm39) |
M220V |
probably benign |
Het |
| Mmp12 |
T |
A |
9: 7,350,002 (GRCm39) |
|
probably benign |
Het |
| Mpp7 |
T |
C |
18: 7,403,269 (GRCm39) |
D347G |
probably benign |
Het |
| Myo3b |
A |
G |
2: 70,180,283 (GRCm39) |
Y1190C |
probably benign |
Het |
| Myo5c |
A |
G |
9: 75,185,525 (GRCm39) |
K963E |
probably benign |
Het |
| Nipbl |
T |
C |
15: 8,322,569 (GRCm39) |
D2614G |
probably damaging |
Het |
| Ppp1r3f |
A |
G |
X: 7,426,821 (GRCm39) |
V480A |
probably benign |
Het |
| Prkcb |
A |
T |
7: 122,116,147 (GRCm39) |
K209* |
probably null |
Het |
| Rasgef1a |
A |
G |
6: 118,066,767 (GRCm39) |
|
probably benign |
Het |
| Ryr3 |
A |
T |
2: 112,784,681 (GRCm39) |
C233* |
probably null |
Het |
| Scn8a |
A |
G |
15: 100,933,520 (GRCm39) |
R1534G |
probably damaging |
Het |
| Slitrk3 |
A |
T |
3: 72,957,263 (GRCm39) |
L503H |
possibly damaging |
Het |
| Spag17 |
A |
G |
3: 99,918,156 (GRCm39) |
K380E |
possibly damaging |
Het |
| Spata31d1a |
A |
G |
13: 59,848,840 (GRCm39) |
V1096A |
possibly damaging |
Het |
| Synrg |
C |
T |
11: 83,930,492 (GRCm39) |
T1278M |
possibly damaging |
Het |
| Teddm1a |
G |
T |
1: 153,767,763 (GRCm39) |
V76F |
possibly damaging |
Het |
| Troap |
A |
G |
15: 98,979,758 (GRCm39) |
T365A |
probably benign |
Het |
| Vps35l |
A |
G |
7: 118,391,776 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Cyp4a29 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02687:Cyp4a29
|
APN |
4 |
115,108,397 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03271:Cyp4a29
|
APN |
4 |
115,111,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03387:Cyp4a29
|
APN |
4 |
115,108,368 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0304:Cyp4a29
|
UTSW |
4 |
115,110,129 (GRCm39) |
splice site |
probably benign |
|
|
R2656:Cyp4a29
|
UTSW |
4 |
115,106,921 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4012:Cyp4a29
|
UTSW |
4 |
115,105,707 (GRCm39) |
missense |
probably benign |
|
|
R4834:Cyp4a29
|
UTSW |
4 |
115,106,867 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4856:Cyp4a29
|
UTSW |
4 |
115,110,078 (GRCm39) |
missense |
probably benign |
|
|
R4886:Cyp4a29
|
UTSW |
4 |
115,110,078 (GRCm39) |
missense |
probably benign |
|
|
R4939:Cyp4a29
|
UTSW |
4 |
115,104,873 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4967:Cyp4a29
|
UTSW |
4 |
115,104,196 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5071:Cyp4a29
|
UTSW |
4 |
115,104,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5072:Cyp4a29
|
UTSW |
4 |
115,104,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5073:Cyp4a29
|
UTSW |
4 |
115,104,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5620:Cyp4a29
|
UTSW |
4 |
115,108,088 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5818:Cyp4a29
|
UTSW |
4 |
115,104,229 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6219:Cyp4a29
|
UTSW |
4 |
115,106,927 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6318:Cyp4a29
|
UTSW |
4 |
115,107,396 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6386:Cyp4a29
|
UTSW |
4 |
115,104,272 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6456:Cyp4a29
|
UTSW |
4 |
115,108,381 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7393:Cyp4a29
|
UTSW |
4 |
115,099,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7443:Cyp4a29
|
UTSW |
4 |
115,105,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7719:Cyp4a29
|
UTSW |
4 |
115,108,137 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7831:Cyp4a29
|
UTSW |
4 |
115,107,367 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7983:Cyp4a29
|
UTSW |
4 |
115,108,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8304:Cyp4a29
|
UTSW |
4 |
115,111,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8674:Cyp4a29
|
UTSW |
4 |
115,106,882 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9109:Cyp4a29
|
UTSW |
4 |
115,108,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9298:Cyp4a29
|
UTSW |
4 |
115,108,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9486:Cyp4a29
|
UTSW |
4 |
115,106,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9601:Cyp4a29
|
UTSW |
4 |
115,105,772 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9667:Cyp4a29
|
UTSW |
4 |
115,111,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9790:Cyp4a29
|
UTSW |
4 |
115,108,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9791:Cyp4a29
|
UTSW |
4 |
115,108,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
U24488:Cyp4a29
|
UTSW |
4 |
115,108,204 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1088:Cyp4a29
|
UTSW |
4 |
115,105,693 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation