Incidental Mutation 'IGL03224:Troap'
ID413741
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Troap
Ensembl Gene ENSMUSG00000032783
Gene Nametrophinin associated protein
SynonymsE130301L11Rik, tastin
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #IGL03224
Quality Score
Status
Chromosome15
Chromosomal Location99074575-99083409 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 99081877 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 365 (T365A)
Ref Sequence ENSEMBL: ENSMUSP00000155404 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039665] [ENSMUST00000064462] [ENSMUST00000230054]
Predicted Effect probably benign
Transcript: ENSMUST00000039665
AA Change: T365A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000035389
Gene: ENSMUSG00000032783
AA Change: T365A

DomainStartEndE-ValueType
low complexity region 232 246 N/A INTRINSIC
low complexity region 390 407 N/A INTRINSIC
low complexity region 468 479 N/A INTRINSIC
low complexity region 499 511 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000064462
SMART Domains Protein: ENSMUSP00000068402
Gene: ENSMUSG00000001076

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
C1Q 103 238 2.34e-34 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183449
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229224
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229740
Predicted Effect probably benign
Transcript: ENSMUST00000230054
AA Change: T365A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230311
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9030624J02Rik A G 7: 118,792,553 probably benign Het
Ash1l T C 3: 89,035,268 probably benign Het
Capn10 T G 1: 92,939,324 V92G probably damaging Het
Cntn2 A G 1: 132,523,042 C532R probably damaging Het
Csf1r T C 18: 61,112,062 F233L probably damaging Het
Cts6 T C 13: 61,201,733 D82G probably damaging Het
Cym T C 3: 107,218,732 S72G possibly damaging Het
Cyp4a29 T A 4: 115,247,050 M105K probably damaging Het
Dhx35 T C 2: 158,857,132 probably benign Het
Dnah5 C A 15: 28,459,154 D4506E probably damaging Het
Dok5 T C 2: 170,832,887 F139L possibly damaging Het
Dync2h1 T C 9: 7,076,235 D2974G probably benign Het
Frem3 C T 8: 80,613,463 T795I probably damaging Het
Ints6l A G X: 56,497,927 T525A probably damaging Het
Lrp1b T C 2: 41,471,031 T587A possibly damaging Het
Meikin A G 11: 54,398,460 M220V probably benign Het
Mmp12 T A 9: 7,350,002 probably benign Het
Mpp7 T C 18: 7,403,269 D347G probably benign Het
Myo3b A G 2: 70,349,939 Y1190C probably benign Het
Myo5c A G 9: 75,278,243 K963E probably benign Het
Nipbl T C 15: 8,293,085 D2614G probably damaging Het
Ppp1r3f A G X: 7,560,582 V480A probably benign Het
Prkcb A T 7: 122,516,924 K209* probably null Het
Rasgef1a A G 6: 118,089,806 probably benign Het
Ryr3 A T 2: 112,954,336 C233* probably null Het
Scn8a A G 15: 101,035,639 R1534G probably damaging Het
Slitrk3 A T 3: 73,049,930 L503H possibly damaging Het
Spag17 A G 3: 100,010,840 K380E possibly damaging Het
Spata31d1a A G 13: 59,701,026 V1096A possibly damaging Het
Synrg C T 11: 84,039,666 T1278M possibly damaging Het
Teddm1a G T 1: 153,892,017 V76F possibly damaging Het
Other mutations in Troap
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01140:Troap APN 15 99082146 missense probably damaging 1.00
IGL01949:Troap APN 15 99081221 missense probably benign 0.08
IGL02468:Troap APN 15 99075361 missense possibly damaging 0.83
IGL02804:Troap APN 15 99077671 splice site probably null
R0617:Troap UTSW 15 99082660 missense probably damaging 1.00
R1085:Troap UTSW 15 99082163 missense probably damaging 0.99
R1872:Troap UTSW 15 99075352 splice site probably benign
R1884:Troap UTSW 15 99077898 missense probably benign 0.00
R1937:Troap UTSW 15 99077388 missense probably damaging 1.00
R2063:Troap UTSW 15 99082463 missense probably benign 0.00
R2065:Troap UTSW 15 99082463 missense probably benign 0.00
R2066:Troap UTSW 15 99082463 missense probably benign 0.00
R2068:Troap UTSW 15 99082463 missense probably benign 0.00
R2087:Troap UTSW 15 99078817 missense possibly damaging 0.84
R2159:Troap UTSW 15 99077586 missense probably damaging 0.96
R4282:Troap UTSW 15 99078832 missense probably benign
R5296:Troap UTSW 15 99078817 missense probably damaging 0.99
R5557:Troap UTSW 15 99075794 missense possibly damaging 0.92
R5652:Troap UTSW 15 99082264 missense probably benign 0.00
R5764:Troap UTSW 15 99075419 missense probably damaging 1.00
R6891:Troap UTSW 15 99082688 missense possibly damaging 0.56
R8008:Troap UTSW 15 99075630 missense probably benign 0.00
RF012:Troap UTSW 15 99075400 missense probably benign 0.10
Z1177:Troap UTSW 15 99077577 missense probably null
Posted On2016-08-02