Incidental Mutation 'IGL03224:Dhx35'
ID 413751
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dhx35
Ensembl Gene ENSMUSG00000027655
Gene Name DEAH-box helicase 35
Synonyms 1200009D07Rik, Ddx35
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL03224
Quality Score
Chromosome 2
Chromosomal Location 158636727-158700134 bp(+) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) T to C at 158699052 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000105104 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029186] [ENSMUST00000109478]
AlphaFold A2ACQ1
Predicted Effect probably benign
Transcript: ENSMUST00000029186
SMART Domains Protein: ENSMUSP00000029186
Gene: ENSMUSG00000027655

DEXDc 55 248 1.17e-18 SMART
HELICc 299 398 8.76e-18 SMART
HA2 458 549 1.49e-27 SMART
Pfam:OB_NTP_bind 628 660 2.7e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109478
SMART Domains Protein: ENSMUSP00000105104
Gene: ENSMUSG00000027655

DEXDc 55 248 1.17e-18 SMART
HELICc 299 398 8.76e-18 SMART
HA2 458 549 1.49e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143195
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145692
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ash1l T C 3: 88,942,575 (GRCm39) probably benign Het
Capn10 T G 1: 92,867,046 (GRCm39) V92G probably damaging Het
Cntn2 A G 1: 132,450,780 (GRCm39) C532R probably damaging Het
Csf1r T C 18: 61,245,134 (GRCm39) F233L probably damaging Het
Cts6 T C 13: 61,349,547 (GRCm39) D82G probably damaging Het
Cym T C 3: 107,126,048 (GRCm39) S72G possibly damaging Het
Cyp4a29 T A 4: 115,104,247 (GRCm39) M105K probably damaging Het
Dnah5 C A 15: 28,459,300 (GRCm39) D4506E probably damaging Het
Dok5 T C 2: 170,674,807 (GRCm39) F139L possibly damaging Het
Dync2h1 T C 9: 7,076,235 (GRCm39) D2974G probably benign Het
Frem3 C T 8: 81,340,092 (GRCm39) T795I probably damaging Het
Ints6l A G X: 55,543,287 (GRCm39) T525A probably damaging Het
Lrp1b T C 2: 41,361,043 (GRCm39) T587A possibly damaging Het
Meikin A G 11: 54,289,286 (GRCm39) M220V probably benign Het
Mmp12 T A 9: 7,350,002 (GRCm39) probably benign Het
Mpp7 T C 18: 7,403,269 (GRCm39) D347G probably benign Het
Myo3b A G 2: 70,180,283 (GRCm39) Y1190C probably benign Het
Myo5c A G 9: 75,185,525 (GRCm39) K963E probably benign Het
Nipbl T C 15: 8,322,569 (GRCm39) D2614G probably damaging Het
Ppp1r3f A G X: 7,426,821 (GRCm39) V480A probably benign Het
Prkcb A T 7: 122,116,147 (GRCm39) K209* probably null Het
Rasgef1a A G 6: 118,066,767 (GRCm39) probably benign Het
Ryr3 A T 2: 112,784,681 (GRCm39) C233* probably null Het
Scn8a A G 15: 100,933,520 (GRCm39) R1534G probably damaging Het
Slitrk3 A T 3: 72,957,263 (GRCm39) L503H possibly damaging Het
Spag17 A G 3: 99,918,156 (GRCm39) K380E possibly damaging Het
Spata31d1a A G 13: 59,848,840 (GRCm39) V1096A possibly damaging Het
Synrg C T 11: 83,930,492 (GRCm39) T1278M possibly damaging Het
Teddm1a G T 1: 153,767,763 (GRCm39) V76F possibly damaging Het
Troap A G 15: 98,979,758 (GRCm39) T365A probably benign Het
Vps35l A G 7: 118,391,776 (GRCm39) probably benign Het
Other mutations in Dhx35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Dhx35 APN 2 158,669,836 (GRCm39) missense probably damaging 1.00
IGL01942:Dhx35 APN 2 158,673,784 (GRCm39) missense probably damaging 1.00
IGL02899:Dhx35 APN 2 158,643,370 (GRCm39) missense probably damaging 1.00
IGL02927:Dhx35 APN 2 158,662,336 (GRCm39) missense probably damaging 1.00
R0112:Dhx35 UTSW 2 158,682,540 (GRCm39) missense probably damaging 0.99
R0200:Dhx35 UTSW 2 158,671,543 (GRCm39) missense probably benign
R0609:Dhx35 UTSW 2 158,659,335 (GRCm39) missense possibly damaging 0.62
R0714:Dhx35 UTSW 2 158,686,103 (GRCm39) missense probably benign
R0884:Dhx35 UTSW 2 158,673,631 (GRCm39) missense probably damaging 0.97
R1775:Dhx35 UTSW 2 158,648,357 (GRCm39) missense probably damaging 1.00
R1912:Dhx35 UTSW 2 158,684,227 (GRCm39) missense probably damaging 0.96
R2136:Dhx35 UTSW 2 158,673,781 (GRCm39) missense probably damaging 1.00
R4094:Dhx35 UTSW 2 158,684,276 (GRCm39) missense probably damaging 1.00
R4364:Dhx35 UTSW 2 158,684,272 (GRCm39) nonsense probably null
R4421:Dhx35 UTSW 2 158,648,321 (GRCm39) missense probably damaging 1.00
R4565:Dhx35 UTSW 2 158,691,455 (GRCm39) missense probably benign 0.01
R5517:Dhx35 UTSW 2 158,676,832 (GRCm39) missense probably damaging 1.00
R5732:Dhx35 UTSW 2 158,673,705 (GRCm39) missense probably damaging 0.99
R5979:Dhx35 UTSW 2 158,684,789 (GRCm39) missense probably benign 0.29
R6054:Dhx35 UTSW 2 158,660,219 (GRCm39) missense probably benign 0.00
R6405:Dhx35 UTSW 2 158,636,839 (GRCm39) missense probably damaging 1.00
R6452:Dhx35 UTSW 2 158,673,607 (GRCm39) missense probably damaging 1.00
R6519:Dhx35 UTSW 2 158,673,630 (GRCm39) missense probably damaging 0.97
R8700:Dhx35 UTSW 2 158,682,552 (GRCm39) missense possibly damaging 0.61
R8894:Dhx35 UTSW 2 158,676,795 (GRCm39) missense possibly damaging 0.77
R8906:Dhx35 UTSW 2 158,648,918 (GRCm39) missense possibly damaging 0.90
R8960:Dhx35 UTSW 2 158,657,393 (GRCm39) missense possibly damaging 0.83
R9349:Dhx35 UTSW 2 158,671,444 (GRCm39) missense possibly damaging 0.94
R9765:Dhx35 UTSW 2 158,671,501 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02