Incidental Mutation 'IGL03228:Cdk15'
| ID |
413794 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Cdk15
|
| Ensembl Gene |
ENSMUSG00000026023 |
| Gene Name |
cyclin dependent kinase 15 |
| Synonyms |
Pftk2, Als2cr7 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03228
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
59296029-59391656 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 59297912 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Asparagine
at position 106
(K106N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109886
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000114248]
[ENSMUST00000160662]
|
| AlphaFold |
Q3V3A1 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000114248
AA Change: K106N
PolyPhen 2
Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000109886
Gene: ENSMUSG00000026023
AA Change: K106N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
101 |
385 |
7.9e-86 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000160662
AA Change: K108N
PolyPhen 2
Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000124680
Gene: ENSMUSG00000026023
AA Change: K108N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
103 |
387 |
7.9e-86 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162487
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arid3a |
G |
A |
10: 79,786,578 (GRCm39) |
V444I |
possibly damaging |
Het |
| Catsperg2 |
T |
C |
7: 29,397,650 (GRCm39) |
Y1021C |
probably damaging |
Het |
| Cbx1 |
A |
G |
11: 96,691,631 (GRCm39) |
|
probably benign |
Het |
| Itpkb |
A |
T |
1: 180,241,564 (GRCm39) |
R745W |
probably damaging |
Het |
| Kdr |
T |
A |
5: 76,117,708 (GRCm39) |
I682F |
probably damaging |
Het |
| Klhl1 |
T |
A |
14: 96,477,763 (GRCm39) |
E435V |
probably damaging |
Het |
| Lamp3 |
T |
A |
16: 19,494,817 (GRCm39) |
Y296F |
possibly damaging |
Het |
| Ltb4r2 |
A |
T |
14: 55,999,408 (GRCm39) |
N10Y |
probably damaging |
Het |
| Mmrn1 |
C |
T |
6: 60,921,876 (GRCm39) |
P111L |
probably benign |
Het |
| Nt5c |
A |
G |
11: 115,381,987 (GRCm39) |
Y107H |
probably damaging |
Het |
| Or2m12 |
A |
C |
16: 19,105,140 (GRCm39) |
L118V |
probably damaging |
Het |
| Or5p53 |
T |
A |
7: 107,533,330 (GRCm39) |
I201N |
possibly damaging |
Het |
| Or8h9 |
A |
G |
2: 86,789,050 (GRCm39) |
F251L |
probably benign |
Het |
| Piezo2 |
T |
A |
18: 63,186,133 (GRCm39) |
S1679C |
probably damaging |
Het |
| Plac8l1 |
T |
A |
18: 42,325,672 (GRCm39) |
S78C |
probably damaging |
Het |
| Scyl2 |
A |
T |
10: 89,485,942 (GRCm39) |
I549N |
probably damaging |
Het |
| Slc51a |
G |
A |
16: 32,297,568 (GRCm39) |
R110C |
probably damaging |
Het |
| Slc6a20b |
G |
T |
9: 123,461,197 (GRCm39) |
Y65* |
probably null |
Het |
| Stx11 |
G |
A |
10: 12,816,956 (GRCm39) |
T256M |
probably benign |
Het |
| Syne2 |
T |
C |
12: 76,026,686 (GRCm39) |
C3505R |
probably benign |
Het |
| Trim75 |
A |
G |
8: 65,436,006 (GRCm39) |
L148P |
probably benign |
Het |
| Ubr4 |
T |
A |
4: 139,156,909 (GRCm39) |
N2311K |
probably damaging |
Het |
| Zfp553 |
A |
G |
7: 126,835,249 (GRCm39) |
H268R |
probably damaging |
Het |
|
| Other mutations in Cdk15 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01307:Cdk15
|
APN |
1 |
59,326,955 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL01612:Cdk15
|
APN |
1 |
59,328,932 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02179:Cdk15
|
APN |
1 |
59,370,100 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
FR4449:Cdk15
|
UTSW |
1 |
59,296,982 (GRCm39) |
small insertion |
probably benign |
|
|
R0270:Cdk15
|
UTSW |
1 |
59,349,965 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1720:Cdk15
|
UTSW |
1 |
59,328,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1958:Cdk15
|
UTSW |
1 |
59,383,475 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1969:Cdk15
|
UTSW |
1 |
59,370,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3159:Cdk15
|
UTSW |
1 |
59,340,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6000:Cdk15
|
UTSW |
1 |
59,328,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6226:Cdk15
|
UTSW |
1 |
59,304,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6257:Cdk15
|
UTSW |
1 |
59,296,264 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7184:Cdk15
|
UTSW |
1 |
59,304,814 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7446:Cdk15
|
UTSW |
1 |
59,328,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7467:Cdk15
|
UTSW |
1 |
59,328,938 (GRCm39) |
missense |
probably null |
0.96 |
|
R7588:Cdk15
|
UTSW |
1 |
59,383,458 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8540:Cdk15
|
UTSW |
1 |
59,349,992 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9024:Cdk15
|
UTSW |
1 |
59,326,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9372:Cdk15
|
UTSW |
1 |
59,370,142 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9404:Cdk15
|
UTSW |
1 |
59,328,914 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9493:Cdk15
|
UTSW |
1 |
59,326,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation