Incidental Mutation 'IGL03229:Or14a256'
ID 413801
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or14a256
Ensembl Gene ENSMUSG00000062042
Gene Name olfactory receptor family 14 subfamily A member 256
Synonyms Olfr294, MOR219-5, GA_x6K02T2NHDJ-9504525-9505532
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # IGL03229
Quality Score
Chromosome 7
Chromosomal Location 86264844-86265851 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 86265286 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 189 (D189G)
Ref Sequence ENSEMBL: ENSMUSP00000077662 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078588]
AlphaFold F7CWV4
Predicted Effect probably benign
Transcript: ENSMUST00000078588
AA Change: D189G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000077662
Gene: ENSMUSG00000062042
AA Change: D189G

Pfam:7tm_4 29 309 1.2e-38 PFAM
Pfam:7tm_1 39 288 1.8e-22 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 T C 5: 8,990,936 (GRCm39) I832T probably damaging Het
Adcyap1r1 T C 6: 55,455,108 (GRCm39) S124P probably damaging Het
Ccn3 A G 15: 54,612,704 (GRCm39) T238A probably benign Het
Coq4 A G 2: 29,678,497 (GRCm39) D41G probably benign Het
Cpb1 A T 3: 20,304,001 (GRCm39) Y354* probably null Het
Dip2b T C 15: 100,105,719 (GRCm39) probably benign Het
Dmxl2 C T 9: 54,311,456 (GRCm39) R1755H probably damaging Het
Dyrk4 G T 6: 126,863,605 (GRCm39) probably benign Het
E2f7 T C 10: 110,590,207 (GRCm39) V120A probably benign Het
Fsip2 A T 2: 82,808,420 (GRCm39) I1580F possibly damaging Het
Gm9755 C A 8: 67,967,324 (GRCm39) noncoding transcript Het
Gprc6a T G 10: 51,492,699 (GRCm39) N480T probably damaging Het
H2ac20 C T 3: 96,127,953 (GRCm39) A70T probably damaging Het
H2-T9 C T 17: 36,438,614 (GRCm39) G259E probably damaging Het
Hdlbp T C 1: 93,357,909 (GRCm39) I331V probably benign Het
Heatr6 G T 11: 83,672,271 (GRCm39) G1093V probably benign Het
Kri1 T C 9: 21,193,366 (GRCm39) E162G probably damaging Het
Nckipsd T C 9: 108,688,813 (GRCm39) V116A probably benign Het
Nek10 A G 14: 14,986,686 (GRCm38) H997R probably benign Het
Nxph1 A G 6: 9,247,830 (GRCm39) Y267C probably damaging Het
Or8k40 A T 2: 86,584,360 (GRCm39) C241S probably damaging Het
Ppip5k2 A T 1: 97,656,686 (GRCm39) V829E probably damaging Het
Prkcz A C 4: 155,346,963 (GRCm39) S573A probably benign Het
Prl2c1 T A 13: 28,040,612 (GRCm39) probably benign Het
Rgs22 T A 15: 36,015,925 (GRCm39) probably benign Het
Scn1a T A 2: 66,130,057 (GRCm39) I1253F probably damaging Het
Tarm1 A G 7: 3,545,413 (GRCm39) C146R probably damaging Het
Tor2a A T 2: 32,649,704 (GRCm39) I189F probably damaging Het
Trappc9 A T 15: 72,930,305 (GRCm39) L17Q probably damaging Het
Trim45 T A 3: 100,830,385 (GRCm39) L53Q probably damaging Het
Ubr7 T C 12: 102,735,414 (GRCm39) L291P probably damaging Het
Unc79 T C 12: 103,100,798 (GRCm39) V1878A probably damaging Het
Wdr90 T C 17: 26,064,437 (GRCm39) probably benign Het
Xpnpep1 T C 19: 53,013,811 (GRCm39) H42R probably benign Het
Zfp750 G A 11: 121,403,778 (GRCm39) H366Y possibly damaging Het
Zmynd11 A G 13: 9,739,601 (GRCm39) C462R probably damaging Het
Other mutations in Or14a256
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01365:Or14a256 APN 7 86,265,205 (GRCm39) missense probably damaging 1.00
IGL02617:Or14a256 APN 7 86,264,872 (GRCm39) missense probably benign 0.14
IGL02694:Or14a256 APN 7 86,265,518 (GRCm39) missense probably benign 0.00
IGL02828:Or14a256 APN 7 86,265,277 (GRCm39) missense possibly damaging 0.67
IGL03351:Or14a256 APN 7 86,264,885 (GRCm39) missense possibly damaging 0.68
PIT4802001:Or14a256 UTSW 7 86,265,763 (GRCm39) missense probably null 1.00
R0848:Or14a256 UTSW 7 86,264,848 (GRCm39) missense probably damaging 0.96
R1448:Or14a256 UTSW 7 86,265,569 (GRCm39) missense probably damaging 1.00
R1720:Or14a256 UTSW 7 86,265,664 (GRCm39) missense probably damaging 1.00
R1734:Or14a256 UTSW 7 86,265,425 (GRCm39) missense probably benign 0.07
R1959:Or14a256 UTSW 7 86,265,639 (GRCm39) missense probably benign 0.00
R2116:Or14a256 UTSW 7 86,265,286 (GRCm39) missense probably benign 0.00
R2518:Or14a256 UTSW 7 86,265,395 (GRCm39) missense probably benign 0.03
R3034:Or14a256 UTSW 7 86,264,970 (GRCm39) missense possibly damaging 0.50
R3110:Or14a256 UTSW 7 86,264,884 (GRCm39) missense probably benign
R3112:Or14a256 UTSW 7 86,264,884 (GRCm39) missense probably benign
R3690:Or14a256 UTSW 7 86,265,686 (GRCm39) missense probably damaging 1.00
R4612:Or14a256 UTSW 7 86,264,944 (GRCm39) missense probably benign 0.00
R6476:Or14a256 UTSW 7 86,265,218 (GRCm39) missense probably benign 0.04
R6895:Or14a256 UTSW 7 86,265,323 (GRCm39) missense probably damaging 1.00
R7102:Or14a256 UTSW 7 86,265,475 (GRCm39) missense probably benign 0.25
R7104:Or14a256 UTSW 7 86,264,900 (GRCm39) missense probably null 0.07
R7179:Or14a256 UTSW 7 86,265,574 (GRCm39) missense possibly damaging 0.76
R7256:Or14a256 UTSW 7 86,264,873 (GRCm39) missense probably benign 0.03
R7624:Or14a256 UTSW 7 86,265,769 (GRCm39) missense possibly damaging 0.47
R8422:Or14a256 UTSW 7 86,265,466 (GRCm39) missense probably benign 0.13
R9432:Or14a256 UTSW 7 86,265,065 (GRCm39) missense possibly damaging 0.66
R9700:Or14a256 UTSW 7 86,265,618 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02