Incidental Mutation 'IGL03229:Tarm1'
ID413832
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tarm1
Ensembl Gene ENSMUSG00000053338
Gene NameT cell-interacting, activating receptor on myeloid cells 1
Synonyms9930022N03Rik, Gm9904
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #IGL03229
Quality Score
Status
Chromosome7
Chromosomal Location3486500-3502624 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 3496897 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Arginine at position 146 (C146R)
Ref Sequence ENSEMBL: ENSMUSP00000145188 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065703] [ENSMUST00000203020] [ENSMUST00000203821]
Predicted Effect probably damaging
Transcript: ENSMUST00000065703
AA Change: C134R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000069745
Gene: ENSMUSG00000053338
AA Change: C134R

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
IG_like 34 120 9.45e0 SMART
IG 131 217 5.28e-3 SMART
transmembrane domain 256 278 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000203020
AA Change: C146R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000145188
Gene: ENSMUSG00000053338
AA Change: C146R

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
IG_like 40 104 4.6e-3 SMART
IG_like 92 198 4.1e-2 SMART
IG 131 217 2.2e-5 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000203821
AA Change: C146R

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000145491
Gene: ENSMUSG00000053338
AA Change: C146R

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
IG_like 34 120 9.45e0 SMART
IG 131 217 5.28e-3 SMART
transmembrane domain 256 278 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 T C 5: 8,940,936 I832T probably damaging Het
Adcyap1r1 T C 6: 55,478,123 S124P probably damaging Het
Coq4 A G 2: 29,788,485 D41G probably benign Het
Cpb1 A T 3: 20,249,837 Y354* probably null Het
Dip2b T C 15: 100,207,838 probably benign Het
Dmxl2 C T 9: 54,404,172 R1755H probably damaging Het
Dyrk4 G T 6: 126,886,642 probably benign Het
E2f7 T C 10: 110,754,346 V120A probably benign Het
Fsip2 A T 2: 82,978,076 I1580F possibly damaging Het
Gm7030 C T 17: 36,127,722 G259E probably damaging Het
Gm9755 C A 8: 67,514,672 noncoding transcript Het
Gprc6a T G 10: 51,616,603 N480T probably damaging Het
Hdlbp T C 1: 93,430,187 I331V probably benign Het
Heatr6 G T 11: 83,781,445 G1093V probably benign Het
Hist2h2ac C T 3: 96,220,637 A70T probably damaging Het
Kri1 T C 9: 21,282,070 E162G probably damaging Het
Nckipsd T C 9: 108,811,614 V116A probably benign Het
Nek10 A G 14: 14,986,686 H997R probably benign Het
Nov A G 15: 54,749,308 T238A probably benign Het
Nxph1 A G 6: 9,247,830 Y267C probably damaging Het
Olfr1090 A T 2: 86,754,016 C241S probably damaging Het
Olfr294 T C 7: 86,616,078 D189G probably benign Het
Ppip5k2 A T 1: 97,728,961 V829E probably damaging Het
Prkcz A C 4: 155,262,506 S573A probably benign Het
Prl2c1 T A 13: 27,856,629 probably benign Het
Rgs22 T A 15: 36,015,779 probably benign Het
Scn1a T A 2: 66,299,713 I1253F probably damaging Het
Tor2a A T 2: 32,759,692 I189F probably damaging Het
Trappc9 A T 15: 73,058,456 L17Q probably damaging Het
Trim45 T A 3: 100,923,069 L53Q probably damaging Het
Ubr7 T C 12: 102,769,155 L291P probably damaging Het
Unc79 T C 12: 103,134,539 V1878A probably damaging Het
Wdr90 T C 17: 25,845,463 probably benign Het
Xpnpep1 T C 19: 53,025,380 H42R probably benign Het
Zfp750 G A 11: 121,512,952 H366Y possibly damaging Het
Zmynd11 A G 13: 9,689,565 C462R probably damaging Het
Other mutations in Tarm1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0096:Tarm1 UTSW 7 3497551 missense probably benign 0.23
R0282:Tarm1 UTSW 7 3497490 missense probably damaging 1.00
R0308:Tarm1 UTSW 7 3496671 splice site probably benign
R3768:Tarm1 UTSW 7 3497581 missense probably benign 0.10
R4732:Tarm1 UTSW 7 3496900 nonsense probably null
R4733:Tarm1 UTSW 7 3496900 nonsense probably null
R4982:Tarm1 UTSW 7 3489096 missense probably damaging 1.00
R5336:Tarm1 UTSW 7 3497568 missense probably damaging 0.99
R6128:Tarm1 UTSW 7 3489204 missense probably benign 0.04
R6746:Tarm1 UTSW 7 3502462 missense probably benign 0.10
R6892:Tarm1 UTSW 7 3497490 missense probably damaging 1.00
R7003:Tarm1 UTSW 7 3497423 critical splice donor site probably null
R7414:Tarm1 UTSW 7 3496802 missense probably benign 0.05
R8439:Tarm1 UTSW 7 3497521 missense possibly damaging 0.69
R8927:Tarm1 UTSW 7 3489203 missense possibly damaging 0.94
Posted On2016-08-02