Incidental Mutation 'IGL03229:Tarm1'
ID 413832
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tarm1
Ensembl Gene ENSMUSG00000053338
Gene Name T cell-interacting, activating receptor on myeloid cells 1
Synonyms Gm9904, 9930022N03Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # IGL03229
Quality Score
Status
Chromosome 7
Chromosomal Location 3535016-3551140 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 3545413 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 146 (C146R)
Ref Sequence ENSEMBL: ENSMUSP00000145188 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065703] [ENSMUST00000203020] [ENSMUST00000203821]
AlphaFold B6A8R8
Predicted Effect probably damaging
Transcript: ENSMUST00000065703
AA Change: C134R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000069745
Gene: ENSMUSG00000053338
AA Change: C134R

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
IG_like 34 120 9.45e0 SMART
IG 131 217 5.28e-3 SMART
transmembrane domain 256 278 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000203020
AA Change: C146R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000145188
Gene: ENSMUSG00000053338
AA Change: C146R

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
IG_like 40 104 4.6e-3 SMART
IG_like 92 198 4.1e-2 SMART
IG 131 217 2.2e-5 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000203821
AA Change: C146R

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000145491
Gene: ENSMUSG00000053338
AA Change: C146R

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
IG_like 34 120 9.45e0 SMART
IG 131 217 5.28e-3 SMART
transmembrane domain 256 278 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 T C 5: 8,990,936 (GRCm39) I832T probably damaging Het
Adcyap1r1 T C 6: 55,455,108 (GRCm39) S124P probably damaging Het
Ccn3 A G 15: 54,612,704 (GRCm39) T238A probably benign Het
Coq4 A G 2: 29,678,497 (GRCm39) D41G probably benign Het
Cpb1 A T 3: 20,304,001 (GRCm39) Y354* probably null Het
Dip2b T C 15: 100,105,719 (GRCm39) probably benign Het
Dmxl2 C T 9: 54,311,456 (GRCm39) R1755H probably damaging Het
Dyrk4 G T 6: 126,863,605 (GRCm39) probably benign Het
E2f7 T C 10: 110,590,207 (GRCm39) V120A probably benign Het
Fsip2 A T 2: 82,808,420 (GRCm39) I1580F possibly damaging Het
Gm9755 C A 8: 67,967,324 (GRCm39) noncoding transcript Het
Gprc6a T G 10: 51,492,699 (GRCm39) N480T probably damaging Het
H2ac20 C T 3: 96,127,953 (GRCm39) A70T probably damaging Het
H2-T9 C T 17: 36,438,614 (GRCm39) G259E probably damaging Het
Hdlbp T C 1: 93,357,909 (GRCm39) I331V probably benign Het
Heatr6 G T 11: 83,672,271 (GRCm39) G1093V probably benign Het
Kri1 T C 9: 21,193,366 (GRCm39) E162G probably damaging Het
Nckipsd T C 9: 108,688,813 (GRCm39) V116A probably benign Het
Nek10 A G 14: 14,986,686 (GRCm38) H997R probably benign Het
Nxph1 A G 6: 9,247,830 (GRCm39) Y267C probably damaging Het
Or14a256 T C 7: 86,265,286 (GRCm39) D189G probably benign Het
Or8k40 A T 2: 86,584,360 (GRCm39) C241S probably damaging Het
Ppip5k2 A T 1: 97,656,686 (GRCm39) V829E probably damaging Het
Prkcz A C 4: 155,346,963 (GRCm39) S573A probably benign Het
Prl2c1 T A 13: 28,040,612 (GRCm39) probably benign Het
Rgs22 T A 15: 36,015,925 (GRCm39) probably benign Het
Scn1a T A 2: 66,130,057 (GRCm39) I1253F probably damaging Het
Tor2a A T 2: 32,649,704 (GRCm39) I189F probably damaging Het
Trappc9 A T 15: 72,930,305 (GRCm39) L17Q probably damaging Het
Trim45 T A 3: 100,830,385 (GRCm39) L53Q probably damaging Het
Ubr7 T C 12: 102,735,414 (GRCm39) L291P probably damaging Het
Unc79 T C 12: 103,100,798 (GRCm39) V1878A probably damaging Het
Wdr90 T C 17: 26,064,437 (GRCm39) probably benign Het
Xpnpep1 T C 19: 53,013,811 (GRCm39) H42R probably benign Het
Zfp750 G A 11: 121,403,778 (GRCm39) H366Y possibly damaging Het
Zmynd11 A G 13: 9,739,601 (GRCm39) C462R probably damaging Het
Other mutations in Tarm1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0096:Tarm1 UTSW 7 3,546,067 (GRCm39) missense probably benign 0.23
R0282:Tarm1 UTSW 7 3,546,006 (GRCm39) missense probably damaging 1.00
R0308:Tarm1 UTSW 7 3,545,187 (GRCm39) splice site probably benign
R3768:Tarm1 UTSW 7 3,546,097 (GRCm39) missense probably benign 0.10
R4732:Tarm1 UTSW 7 3,545,416 (GRCm39) nonsense probably null
R4733:Tarm1 UTSW 7 3,545,416 (GRCm39) nonsense probably null
R4982:Tarm1 UTSW 7 3,537,612 (GRCm39) missense probably damaging 1.00
R5336:Tarm1 UTSW 7 3,546,084 (GRCm39) missense probably damaging 0.99
R6128:Tarm1 UTSW 7 3,537,720 (GRCm39) missense probably benign 0.04
R6746:Tarm1 UTSW 7 3,550,978 (GRCm39) missense probably benign 0.10
R6892:Tarm1 UTSW 7 3,546,006 (GRCm39) missense probably damaging 1.00
R7003:Tarm1 UTSW 7 3,545,939 (GRCm39) critical splice donor site probably null
R7414:Tarm1 UTSW 7 3,545,318 (GRCm39) missense probably benign 0.05
R8439:Tarm1 UTSW 7 3,546,037 (GRCm39) missense possibly damaging 0.69
R8925:Tarm1 UTSW 7 3,537,719 (GRCm39) missense possibly damaging 0.94
R8927:Tarm1 UTSW 7 3,537,719 (GRCm39) missense possibly damaging 0.94
R9608:Tarm1 UTSW 7 3,551,062 (GRCm39) start gained probably benign
R9687:Tarm1 UTSW 7 3,544,457 (GRCm39) missense probably benign
Posted On 2016-08-02