Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03229:Prl2c1'

413837

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prl2c1

Ensembl Gene

ENSMUSG00000062551

Gene Name

Prolactin family 2, subfamily c, member 1

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL03229

Quality Score

Status

Chromosome

Chromosomal Location

28033325-28041771 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 28040612 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000105964 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054932] [ENSMUST00000110335]

AlphaFold

Q5SVL9

Predicted Effect

probably benign
Transcript: ENSMUST00000054932

SMART Domains

Protein: ENSMUSP00000053446
Gene: ENSMUSG00000062551

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	16	226	1.8e-73	PFAM

Predicted Effect

SMART Domains

Protein: ENSMUSP00000078221
Gene: ENSMUSG00000062551

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	16	72	7.1e-14	PFAM
Pfam:Hormone_1	70	192	4.1e-41	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000110335

SMART Domains

Protein: ENSMUSP00000105964
Gene: ENSMUSG00000062551

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	16	228	1.9e-77	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb4	T	C	5: 8,990,936 (GRCm39)	I832T	probably damaging	Het
Adcyap1r1	T	C	6: 55,455,108 (GRCm39)	S124P	probably damaging	Het
Ccn3	A	G	15: 54,612,704 (GRCm39)	T238A	probably benign	Het
Coq4	A	G	2: 29,678,497 (GRCm39)	D41G	probably benign	Het
Cpb1	A	T	3: 20,304,001 (GRCm39)	Y354*	probably null	Het
Dip2b	T	C	15: 100,105,719 (GRCm39)		probably benign	Het
Dmxl2	C	T	9: 54,311,456 (GRCm39)	R1755H	probably damaging	Het
Dyrk4	G	T	6: 126,863,605 (GRCm39)		probably benign	Het
E2f7	T	C	10: 110,590,207 (GRCm39)	V120A	probably benign	Het
Fsip2	A	T	2: 82,808,420 (GRCm39)	I1580F	possibly damaging	Het
Gm9755	C	A	8: 67,967,324 (GRCm39)		noncoding transcript	Het
Gprc6a	T	G	10: 51,492,699 (GRCm39)	N480T	probably damaging	Het
H2ac20	C	T	3: 96,127,953 (GRCm39)	A70T	probably damaging	Het
H2-T9	C	T	17: 36,438,614 (GRCm39)	G259E	probably damaging	Het
Hdlbp	T	C	1: 93,357,909 (GRCm39)	I331V	probably benign	Het
Heatr6	G	T	11: 83,672,271 (GRCm39)	G1093V	probably benign	Het
Kri1	T	C	9: 21,193,366 (GRCm39)	E162G	probably damaging	Het
Nckipsd	T	C	9: 108,688,813 (GRCm39)	V116A	probably benign	Het
Nek10	A	G	14: 14,986,686 (GRCm38)	H997R	probably benign	Het
Nxph1	A	G	6: 9,247,830 (GRCm39)	Y267C	probably damaging	Het
Or14a256	T	C	7: 86,265,286 (GRCm39)	D189G	probably benign	Het
Or8k40	A	T	2: 86,584,360 (GRCm39)	C241S	probably damaging	Het
Ppip5k2	A	T	1: 97,656,686 (GRCm39)	V829E	probably damaging	Het
Prkcz	A	C	4: 155,346,963 (GRCm39)	S573A	probably benign	Het
Rgs22	T	A	15: 36,015,925 (GRCm39)		probably benign	Het
Scn1a	T	A	2: 66,130,057 (GRCm39)	I1253F	probably damaging	Het
Tarm1	A	G	7: 3,545,413 (GRCm39)	C146R	probably damaging	Het
Tor2a	A	T	2: 32,649,704 (GRCm39)	I189F	probably damaging	Het
Trappc9	A	T	15: 72,930,305 (GRCm39)	L17Q	probably damaging	Het
Trim45	T	A	3: 100,830,385 (GRCm39)	L53Q	probably damaging	Het
Ubr7	T	C	12: 102,735,414 (GRCm39)	L291P	probably damaging	Het
Unc79	T	C	12: 103,100,798 (GRCm39)	V1878A	probably damaging	Het
Wdr90	T	C	17: 26,064,437 (GRCm39)		probably benign	Het
Xpnpep1	T	C	19: 53,013,811 (GRCm39)	H42R	probably benign	Het
Zfp750	G	A	11: 121,403,778 (GRCm39)	H366Y	possibly damaging	Het
Zmynd11	A	G	13: 9,739,601 (GRCm39)	C462R	probably damaging	Het

Other mutations in Prl2c1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02630:Prl2c1	APN	13	28,041,480 (GRCm39)	splice site	probably benign
IGL02648:Prl2c1	APN	13	28,041,542 (GRCm39)	missense	probably benign	0.44
IGL02823:Prl2c1	APN	13	28,040,416 (GRCm39)	splice site	probably benign
IGL03024:Prl2c1	APN	13	28,040,524 (GRCm39)	missense	probably benign	0.22
R4739:Prl2c1	UTSW	13	28,041,661 (GRCm39)	missense	probably damaging	1.00
R4978:Prl2c1	UTSW	13	28,041,553 (GRCm39)	missense	probably benign	0.00
R6860:Prl2c1	UTSW	13	28,035,724 (GRCm39)	missense	probably benign	0.31
R7719:Prl2c1	UTSW	13	28,035,780 (GRCm39)	missense	probably damaging	1.00
R7984:Prl2c1	UTSW	13	28,039,310 (GRCm39)	critical splice donor site	probably null
R8795:Prl2c1	UTSW	13	28,033,390 (GRCm39)	missense	probably benign	0.02
R8795:Prl2c1	UTSW	13	28,033,389 (GRCm39)	missense	possibly damaging	0.86

Posted On

2016-08-02