Incidental Mutation 'IGL03230:Oas1a'
ID 413846
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oas1a
Ensembl Gene ENSMUSG00000052776
Gene Name 2'-5' oligoadenylate synthetase 1A
Synonyms L3
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03230
Quality Score
Status
Chromosome 5
Chromosomal Location 121034319-121045584 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 121036419 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Isoleucine at position 336 (K336I)
Ref Sequence ENSEMBL: ENSMUSP00000079198 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080322]
AlphaFold P11928
Predicted Effect probably benign
Transcript: ENSMUST00000080322
AA Change: K336I

PolyPhen 2 Score 0.235 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000079198
Gene: ENSMUSG00000052776
AA Change: K336I

DomainStartEndE-ValueType
Pfam:NTP_transf_2 38 139 9.8e-14 PFAM
Pfam:OAS1_C 164 349 1.9e-87 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 C A 11: 9,244,313 (GRCm39) Q2059K probably benign Het
Abcc1 A T 16: 14,275,811 (GRCm39) T902S probably benign Het
Acly A T 11: 100,384,885 (GRCm39) C623S probably damaging Het
Ak8 A G 2: 28,599,935 (GRCm39) probably benign Het
Birc6 A G 17: 74,918,065 (GRCm39) D1811G probably damaging Het
Bms1 T A 6: 118,395,522 (GRCm39) K8N possibly damaging Het
Cdc25b T C 2: 131,030,060 (GRCm39) F79L probably benign Het
Cdh13 T A 8: 119,969,056 (GRCm39) V471D probably damaging Het
Cnot4 T C 6: 35,028,344 (GRCm39) D424G probably damaging Het
Cyp2a12 A T 7: 26,729,017 (GRCm39) I70F possibly damaging Het
Cyp2c66 A T 19: 39,172,302 (GRCm39) R406W possibly damaging Het
Cyp2g1 C A 7: 26,518,828 (GRCm39) P408Q probably damaging Het
Defa26 A G 8: 22,108,314 (GRCm39) D39G probably damaging Het
Dnah1 A T 14: 30,992,023 (GRCm39) S3020T probably damaging Het
Dst A T 1: 34,223,133 (GRCm39) K1119* probably null Het
Gm10110 A C 14: 90,135,733 (GRCm39) noncoding transcript Het
Grk2 C T 19: 4,337,857 (GRCm39) E508K probably benign Het
Hpx A T 7: 105,248,519 (GRCm39) I94N probably benign Het
Il23r C T 6: 67,400,948 (GRCm39) A461T probably benign Het
Iqca1 A G 1: 90,072,724 (GRCm39) I52T probably damaging Het
Kif21b T A 1: 136,090,550 (GRCm39) M1146K probably benign Het
Kifap3 C A 1: 163,653,293 (GRCm39) T293K probably benign Het
Luzp1 G A 4: 136,270,189 (GRCm39) S804N probably benign Het
Mcmdc2 C T 1: 10,002,221 (GRCm39) probably benign Het
Mctp1 G T 13: 76,972,976 (GRCm39) A403S possibly damaging Het
Mtnr1a T C 8: 45,540,435 (GRCm39) I132T probably damaging Het
Musk T A 4: 58,296,710 (GRCm39) N103K probably damaging Het
Nipal2 T A 15: 34,575,702 (GRCm39) D352V probably damaging Het
Oasl1 T C 5: 115,075,115 (GRCm39) S392P probably damaging Het
Or2ag17 A G 7: 106,389,911 (GRCm39) L99P probably damaging Het
Or3a1c A G 11: 74,046,099 (GRCm39) T40A probably benign Het
Or4c117 A G 2: 88,955,892 (GRCm39) F61S probably damaging Het
Or4c120 A T 2: 89,001,433 (GRCm39) M41K possibly damaging Het
Or4c58 T C 2: 89,674,457 (GRCm39) T287A probably benign Het
Or5m8 A T 2: 85,822,583 (GRCm39) T141S probably benign Het
Pate3 T G 9: 35,557,402 (GRCm39) T85P probably benign Het
Piezo2 T C 18: 63,174,791 (GRCm39) N1988D probably damaging Het
Plcxd3 T A 15: 4,546,272 (GRCm39) I92N probably damaging Het
Ptprd T A 4: 75,968,654 (GRCm39) R213* probably null Het
Skic3 T A 13: 76,303,766 (GRCm39) probably benign Het
Slit1 T C 19: 41,717,524 (GRCm39) D80G probably damaging Het
Sorcs1 A G 19: 50,230,531 (GRCm39) V472A probably damaging Het
Trp63 T A 16: 25,707,760 (GRCm39) D485E probably damaging Het
Tsr1 T C 11: 74,791,297 (GRCm39) V292A probably benign Het
Ush2a G T 1: 188,198,390 (GRCm39) A1485S probably benign Het
Vmn1r49 T A 6: 90,049,650 (GRCm39) R117S probably damaging Het
Vmn2r97 C A 17: 19,149,668 (GRCm39) P352H probably benign Het
Zxdc C T 6: 90,350,785 (GRCm39) T412I probably damaging Het
Other mutations in Oas1a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01822:Oas1a APN 5 121,037,277 (GRCm39) missense probably benign 0.01
IGL02299:Oas1a APN 5 121,043,755 (GRCm39) missense probably benign
IGL02951:Oas1a APN 5 121,043,727 (GRCm39) missense probably damaging 1.00
IGL03112:Oas1a APN 5 121,036,412 (GRCm39) missense possibly damaging 0.95
IGL03356:Oas1a APN 5 121,043,908 (GRCm39) missense probably damaging 0.99
IGL03379:Oas1a APN 5 121,035,062 (GRCm39) missense possibly damaging 0.70
R0625:Oas1a UTSW 5 121,037,322 (GRCm39) missense probably damaging 1.00
R1279:Oas1a UTSW 5 121,035,241 (GRCm39) critical splice donor site probably null
R1914:Oas1a UTSW 5 121,043,876 (GRCm39) missense possibly damaging 0.48
R1915:Oas1a UTSW 5 121,043,876 (GRCm39) missense possibly damaging 0.48
R4758:Oas1a UTSW 5 121,045,401 (GRCm39) missense probably damaging 1.00
R4928:Oas1a UTSW 5 121,043,787 (GRCm39) missense probably benign
R5267:Oas1a UTSW 5 121,037,284 (GRCm39) missense probably benign 0.00
R5442:Oas1a UTSW 5 121,035,269 (GRCm39) missense probably benign 0.00
R5487:Oas1a UTSW 5 121,045,490 (GRCm39) missense probably damaging 1.00
R6853:Oas1a UTSW 5 121,045,491 (GRCm39) missense possibly damaging 0.95
R6880:Oas1a UTSW 5 121,040,003 (GRCm39) missense probably damaging 0.97
R7953:Oas1a UTSW 5 121,035,080 (GRCm39) missense probably benign 0.32
R8043:Oas1a UTSW 5 121,035,080 (GRCm39) missense probably benign 0.32
R8363:Oas1a UTSW 5 121,043,902 (GRCm39) missense probably damaging 1.00
R8738:Oas1a UTSW 5 121,040,019 (GRCm39) missense probably damaging 1.00
R8863:Oas1a UTSW 5 121,043,943 (GRCm39) missense probably damaging 1.00
R9474:Oas1a UTSW 5 121,037,317 (GRCm39) missense probably damaging 1.00
R9475:Oas1a UTSW 5 121,037,317 (GRCm39) missense probably damaging 1.00
R9612:Oas1a UTSW 5 121,040,028 (GRCm39) missense possibly damaging 0.70
Z1177:Oas1a UTSW 5 121,039,958 (GRCm39) missense possibly damaging 0.75
Posted On 2016-08-02