Incidental Mutation 'IGL03230:Cyp2g1'
ID 413859
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2g1
Ensembl Gene ENSMUSG00000049685
Gene Name cytochrome P450, family 2, subfamily g, polypeptide 1
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03230
Quality Score
Status
Chromosome 7
Chromosomal Location 26808892-26821205 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to A at 26819403 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Proline to Glutamine at position 408 (P408Q)
Ref Sequence ENSEMBL: ENSMUSP00000047150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040944]
AlphaFold Q9WV19
Predicted Effect probably damaging
Transcript: ENSMUST00000040944
AA Change: P408Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000047150
Gene: ENSMUSG00000049685
AA Change: P408Q

DomainStartEndE-ValueType
low complexity region 12 23 N/A INTRINSIC
Pfam:p450 34 491 4e-150 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205273
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 C A 11: 9,294,313 Q2059K probably benign Het
Abcc1 A T 16: 14,457,947 T902S probably benign Het
Acly A T 11: 100,494,059 C623S probably damaging Het
Ak8 A G 2: 28,709,923 probably benign Het
Birc6 A G 17: 74,611,070 D1811G probably damaging Het
Bms1 T A 6: 118,418,561 K8N possibly damaging Het
Cdc25b T C 2: 131,188,140 F79L probably benign Het
Cdh13 T A 8: 119,242,317 V471D probably damaging Het
Cnot4 T C 6: 35,051,409 D424G probably damaging Het
Cyp2a12 A T 7: 27,029,592 I70F possibly damaging Het
Cyp2c66 A T 19: 39,183,858 R406W possibly damaging Het
Defa26 A G 8: 21,618,298 D39G probably damaging Het
Dnah1 A T 14: 31,270,066 S3020T probably damaging Het
Dst A T 1: 34,184,052 K1119* probably null Het
Gm10110 A C 14: 89,898,297 noncoding transcript Het
Grk2 C T 19: 4,287,829 E508K probably benign Het
Hpx A T 7: 105,599,312 I94N probably benign Het
Il23r C T 6: 67,423,964 A461T probably benign Het
Iqca A G 1: 90,145,002 I52T probably damaging Het
Kif21b T A 1: 136,162,812 M1146K probably benign Het
Kifap3 C A 1: 163,825,724 T293K probably benign Het
Luzp1 G A 4: 136,542,878 S804N probably benign Het
Mcmdc2 C T 1: 9,931,996 probably benign Het
Mctp1 G T 13: 76,824,857 A403S possibly damaging Het
Mtnr1a T C 8: 45,087,398 I132T probably damaging Het
Musk T A 4: 58,296,710 N103K probably damaging Het
Nipal2 T A 15: 34,575,556 D352V probably damaging Het
Oas1a T A 5: 120,898,356 K336I probably benign Het
Oasl1 T C 5: 114,937,056 S392P probably damaging Het
Olfr1031 A T 2: 85,992,239 T141S probably benign Het
Olfr1222 A G 2: 89,125,548 F61S probably damaging Het
Olfr1225 A T 2: 89,171,089 M41K possibly damaging Het
Olfr402 A G 11: 74,155,273 T40A probably benign Het
Olfr48 T C 2: 89,844,113 T287A probably benign Het
Olfr699 A G 7: 106,790,704 L99P probably damaging Het
Pate3 T G 9: 35,646,106 T85P probably benign Het
Piezo2 T C 18: 63,041,720 N1988D probably damaging Het
Plcxd3 T A 15: 4,516,790 I92N probably damaging Het
Ptprd T A 4: 76,050,417 R213* probably null Het
Slit1 T C 19: 41,729,085 D80G probably damaging Het
Sorcs1 A G 19: 50,242,093 V472A probably damaging Het
Trp63 T A 16: 25,889,010 D485E probably damaging Het
Tsr1 T C 11: 74,900,471 V292A probably benign Het
Ttc37 T A 13: 76,155,647 probably benign Het
Ush2a G T 1: 188,466,193 A1485S probably benign Het
Vmn1r49 T A 6: 90,072,668 R117S probably damaging Het
Vmn2r97 C A 17: 18,929,406 P352H probably benign Het
Zxdc C T 6: 90,373,803 T412I probably damaging Het
Other mutations in Cyp2g1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01134:Cyp2g1 APN 7 26809831 missense probably benign 0.05
IGL01137:Cyp2g1 APN 7 26814259 missense possibly damaging 0.87
IGL02052:Cyp2g1 APN 7 26814294 splice site probably benign
IGL02338:Cyp2g1 APN 7 26814804 splice site probably benign
IGL02452:Cyp2g1 APN 7 26811446 missense probably benign 0.28
IGL02523:Cyp2g1 APN 7 26819187 missense probably damaging 1.00
IGL03165:Cyp2g1 APN 7 26809776 missense possibly damaging 0.94
PIT4472001:Cyp2g1 UTSW 7 26814194 missense probably benign 0.28
R0106:Cyp2g1 UTSW 7 26814182 missense probably damaging 1.00
R0106:Cyp2g1 UTSW 7 26814182 missense probably damaging 1.00
R0380:Cyp2g1 UTSW 7 26814295 splice site probably benign
R0697:Cyp2g1 UTSW 7 26814727 nonsense probably null
R0830:Cyp2g1 UTSW 7 26814791 missense probably benign 0.00
R1660:Cyp2g1 UTSW 7 26809682 critical splice acceptor site probably null
R2093:Cyp2g1 UTSW 7 26819433 missense probably benign 0.35
R2131:Cyp2g1 UTSW 7 26820710 missense probably damaging 0.99
R4606:Cyp2g1 UTSW 7 26814154 missense possibly damaging 0.80
R5030:Cyp2g1 UTSW 7 26820801 missense probably benign 0.06
R5574:Cyp2g1 UTSW 7 26820740 missense possibly damaging 0.81
R5877:Cyp2g1 UTSW 7 26816640 missense possibly damaging 0.80
R6745:Cyp2g1 UTSW 7 26814179 missense probably damaging 1.00
R7040:Cyp2g1 UTSW 7 26820759 missense probably damaging 0.99
R7223:Cyp2g1 UTSW 7 26814632 missense probably damaging 0.98
R7934:Cyp2g1 UTSW 7 26819193 missense probably damaging 1.00
R8112:Cyp2g1 UTSW 7 26819461 missense probably benign
R8177:Cyp2g1 UTSW 7 26819153 missense probably damaging 1.00
R8194:Cyp2g1 UTSW 7 26814734 missense possibly damaging 0.89
R9043:Cyp2g1 UTSW 7 26809831 missense probably benign 0.05
R9406:Cyp2g1 UTSW 7 26819485 critical splice donor site probably null
X0067:Cyp2g1 UTSW 7 26820762 missense possibly damaging 0.70
Posted On 2016-08-02