Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03230:Vmn2r97'

413863

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r97

Ensembl Gene

ENSMUSG00000091491

Gene Name

vomeronasal 2, receptor 97

Synonyms

EG627367

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL03230

Quality Score

Status

Chromosome

Chromosomal Location

19134584-19168333 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 19149668 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Histidine at position 352 (P352H)

Ref Sequence

ENSEMBL: ENSMUSP00000156141 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168710] [ENSMUST00000232219]

AlphaFold

K7N6Z2

Predicted Effect

probably benign
Transcript: ENSMUST00000168710
AA Change: P352H

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: P352H

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	82	442	2.9e-36	PFAM
Pfam:NCD3G	513	566	4.9e-21	PFAM
Pfam:7tm_3	599	834	1.7e-52	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000232219
AA Change: P352H

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232325

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	C	A	11: 9,244,313 (GRCm39)	Q2059K	probably benign	Het
Abcc1	A	T	16: 14,275,811 (GRCm39)	T902S	probably benign	Het
Acly	A	T	11: 100,384,885 (GRCm39)	C623S	probably damaging	Het
Ak8	A	G	2: 28,599,935 (GRCm39)		probably benign	Het
Birc6	A	G	17: 74,918,065 (GRCm39)	D1811G	probably damaging	Het
Bms1	T	A	6: 118,395,522 (GRCm39)	K8N	possibly damaging	Het
Cdc25b	T	C	2: 131,030,060 (GRCm39)	F79L	probably benign	Het
Cdh13	T	A	8: 119,969,056 (GRCm39)	V471D	probably damaging	Het
Cnot4	T	C	6: 35,028,344 (GRCm39)	D424G	probably damaging	Het
Cyp2a12	A	T	7: 26,729,017 (GRCm39)	I70F	possibly damaging	Het
Cyp2c66	A	T	19: 39,172,302 (GRCm39)	R406W	possibly damaging	Het
Cyp2g1	C	A	7: 26,518,828 (GRCm39)	P408Q	probably damaging	Het
Defa26	A	G	8: 22,108,314 (GRCm39)	D39G	probably damaging	Het
Dnah1	A	T	14: 30,992,023 (GRCm39)	S3020T	probably damaging	Het
Dst	A	T	1: 34,223,133 (GRCm39)	K1119*	probably null	Het
Gm10110	A	C	14: 90,135,733 (GRCm39)		noncoding transcript	Het
Grk2	C	T	19: 4,337,857 (GRCm39)	E508K	probably benign	Het
Hpx	A	T	7: 105,248,519 (GRCm39)	I94N	probably benign	Het
Il23r	C	T	6: 67,400,948 (GRCm39)	A461T	probably benign	Het
Iqca1	A	G	1: 90,072,724 (GRCm39)	I52T	probably damaging	Het
Kif21b	T	A	1: 136,090,550 (GRCm39)	M1146K	probably benign	Het
Kifap3	C	A	1: 163,653,293 (GRCm39)	T293K	probably benign	Het
Luzp1	G	A	4: 136,270,189 (GRCm39)	S804N	probably benign	Het
Mcmdc2	C	T	1: 10,002,221 (GRCm39)		probably benign	Het
Mctp1	G	T	13: 76,972,976 (GRCm39)	A403S	possibly damaging	Het
Mtnr1a	T	C	8: 45,540,435 (GRCm39)	I132T	probably damaging	Het
Musk	T	A	4: 58,296,710 (GRCm39)	N103K	probably damaging	Het
Nipal2	T	A	15: 34,575,702 (GRCm39)	D352V	probably damaging	Het
Oas1a	T	A	5: 121,036,419 (GRCm39)	K336I	probably benign	Het
Oasl1	T	C	5: 115,075,115 (GRCm39)	S392P	probably damaging	Het
Or2ag17	A	G	7: 106,389,911 (GRCm39)	L99P	probably damaging	Het
Or3a1c	A	G	11: 74,046,099 (GRCm39)	T40A	probably benign	Het
Or4c117	A	G	2: 88,955,892 (GRCm39)	F61S	probably damaging	Het
Or4c120	A	T	2: 89,001,433 (GRCm39)	M41K	possibly damaging	Het
Or4c58	T	C	2: 89,674,457 (GRCm39)	T287A	probably benign	Het
Or5m8	A	T	2: 85,822,583 (GRCm39)	T141S	probably benign	Het
Pate3	T	G	9: 35,557,402 (GRCm39)	T85P	probably benign	Het
Piezo2	T	C	18: 63,174,791 (GRCm39)	N1988D	probably damaging	Het
Plcxd3	T	A	15: 4,546,272 (GRCm39)	I92N	probably damaging	Het
Ptprd	T	A	4: 75,968,654 (GRCm39)	R213*	probably null	Het
Skic3	T	A	13: 76,303,766 (GRCm39)		probably benign	Het
Slit1	T	C	19: 41,717,524 (GRCm39)	D80G	probably damaging	Het
Sorcs1	A	G	19: 50,230,531 (GRCm39)	V472A	probably damaging	Het
Trp63	T	A	16: 25,707,760 (GRCm39)	D485E	probably damaging	Het
Tsr1	T	C	11: 74,791,297 (GRCm39)	V292A	probably benign	Het
Ush2a	G	T	1: 188,198,390 (GRCm39)	A1485S	probably benign	Het
Vmn1r49	T	A	6: 90,049,650 (GRCm39)	R117S	probably damaging	Het
Zxdc	C	T	6: 90,350,785 (GRCm39)	T412I	probably damaging	Het

Other mutations in Vmn2r97

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r97	APN	17	19,167,921 (GRCm39)	missense	probably benign	0.37
IGL00962:Vmn2r97	APN	17	19,149,490 (GRCm39)	missense	probably damaging	1.00
IGL01704:Vmn2r97	APN	17	19,168,073 (GRCm39)	missense	probably damaging	0.99
IGL01888:Vmn2r97	APN	17	19,149,286 (GRCm39)	nonsense	probably null
IGL02429:Vmn2r97	APN	17	19,150,596 (GRCm39)	missense	possibly damaging	0.94
IGL02742:Vmn2r97	APN	17	19,149,432 (GRCm39)	missense	probably damaging	0.97
IGL02934:Vmn2r97	APN	17	19,149,947 (GRCm39)	missense	probably benign	0.00
IGL02978:Vmn2r97	APN	17	19,168,298 (GRCm39)	missense	probably benign	0.01
IGL03241:Vmn2r97	APN	17	19,148,438 (GRCm39)	missense	probably benign	0.11
IGL03050:Vmn2r97	UTSW	17	19,167,900 (GRCm39)	missense	possibly damaging	0.84
PIT4469001:Vmn2r97	UTSW	17	19,149,878 (GRCm39)	missense	probably benign	0.00
R0482:Vmn2r97	UTSW	17	19,167,930 (GRCm39)	missense	probably damaging	1.00
R0514:Vmn2r97	UTSW	17	19,134,734 (GRCm39)	missense	probably benign	0.25
R0944:Vmn2r97	UTSW	17	19,167,665 (GRCm39)	missense	probably benign	0.13
R1061:Vmn2r97	UTSW	17	19,148,440 (GRCm39)	nonsense	probably null
R1546:Vmn2r97	UTSW	17	19,168,110 (GRCm39)	missense	probably damaging	1.00
R1725:Vmn2r97	UTSW	17	19,149,397 (GRCm39)	missense	probably benign	0.43
R1860:Vmn2r97	UTSW	17	19,167,648 (GRCm39)	missense	probably benign	0.01
R1938:Vmn2r97	UTSW	17	19,149,593 (GRCm39)	missense	probably benign	0.01
R1944:Vmn2r97	UTSW	17	19,160,500 (GRCm39)	missense	probably benign	0.00
R2027:Vmn2r97	UTSW	17	19,149,944 (GRCm39)	missense	unknown
R2106:Vmn2r97	UTSW	17	19,168,100 (GRCm39)	missense	probably damaging	1.00
R2151:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2153:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2154:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2516:Vmn2r97	UTSW	17	19,167,814 (GRCm39)	missense	probably benign
R3739:Vmn2r97	UTSW	17	19,148,413 (GRCm39)	missense	probably damaging	1.00
R3744:Vmn2r97	UTSW	17	19,149,890 (GRCm39)	missense	probably benign
R3885:Vmn2r97	UTSW	17	19,148,596 (GRCm39)	missense	possibly damaging	0.90
R3899:Vmn2r97	UTSW	17	19,167,873 (GRCm39)	missense	probably damaging	0.96
R4115:Vmn2r97	UTSW	17	19,148,332 (GRCm39)	missense	probably benign	0.01
R4247:Vmn2r97	UTSW	17	19,167,542 (GRCm39)	missense	possibly damaging	0.83
R4287:Vmn2r97	UTSW	17	19,168,337 (GRCm39)	intron	probably benign
R4439:Vmn2r97	UTSW	17	19,150,616 (GRCm39)	missense	probably benign	0.00
R4523:Vmn2r97	UTSW	17	19,149,333 (GRCm39)	missense	probably benign	0.03
R4783:Vmn2r97	UTSW	17	19,149,550 (GRCm39)	missense	probably benign
R4948:Vmn2r97	UTSW	17	19,167,561 (GRCm39)	missense	possibly damaging	0.95
R4981:Vmn2r97	UTSW	17	19,160,436 (GRCm39)	nonsense	probably null
R5029:Vmn2r97	UTSW	17	19,168,173 (GRCm39)	missense	probably damaging	1.00
R5200:Vmn2r97	UTSW	17	19,148,615 (GRCm39)	missense	probably damaging	1.00
R5541:Vmn2r97	UTSW	17	19,148,617 (GRCm39)	nonsense	probably null
R5637:Vmn2r97	UTSW	17	19,167,628 (GRCm39)	nonsense	probably null
R5765:Vmn2r97	UTSW	17	19,167,442 (GRCm39)	nonsense	probably null
R5885:Vmn2r97	UTSW	17	19,168,035 (GRCm39)	missense	possibly damaging	0.50
R6272:Vmn2r97	UTSW	17	19,167,861 (GRCm39)	missense	possibly damaging	0.70
R6553:Vmn2r97	UTSW	17	19,150,566 (GRCm39)	nonsense	probably null
R6818:Vmn2r97	UTSW	17	19,168,193 (GRCm39)	missense	possibly damaging	0.95
R6880:Vmn2r97	UTSW	17	19,134,770 (GRCm39)	missense	probably benign	0.00
R7012:Vmn2r97	UTSW	17	19,167,756 (GRCm39)	missense	probably damaging	0.99
R7023:Vmn2r97	UTSW	17	19,134,663 (GRCm39)	missense	probably damaging	1.00
R7044:Vmn2r97	UTSW	17	19,134,629 (GRCm39)	missense	probably benign	0.05
R7191:Vmn2r97	UTSW	17	19,150,548 (GRCm39)	missense	probably damaging	1.00
R7503:Vmn2r97	UTSW	17	19,148,470 (GRCm39)	missense	probably benign
R7862:Vmn2r97	UTSW	17	19,167,416 (GRCm39)	missense	probably damaging	1.00
R7876:Vmn2r97	UTSW	17	19,149,326 (GRCm39)	missense	probably damaging	0.97
R7890:Vmn2r97	UTSW	17	19,149,802 (GRCm39)	missense	probably benign	0.00
R7936:Vmn2r97	UTSW	17	19,150,662 (GRCm39)	missense	probably damaging	1.00
R7978:Vmn2r97	UTSW	17	19,167,854 (GRCm39)	missense	probably damaging	1.00
R8405:Vmn2r97	UTSW	17	19,134,802 (GRCm39)	critical splice donor site	probably null
R8755:Vmn2r97	UTSW	17	19,168,104 (GRCm39)	missense	probably damaging	1.00
R8790:Vmn2r97	UTSW	17	19,160,472 (GRCm39)	missense	probably damaging	1.00
R8850:Vmn2r97	UTSW	17	19,149,607 (GRCm39)	missense	probably benign	0.00
R9060:Vmn2r97	UTSW	17	19,134,585 (GRCm39)	start codon destroyed	probably null	0.94
R9079:Vmn2r97	UTSW	17	19,149,640 (GRCm39)	missense	probably benign
R9252:Vmn2r97	UTSW	17	19,167,849 (GRCm39)	missense	probably benign	0.00
R9278:Vmn2r97	UTSW	17	19,134,762 (GRCm39)	missense	probably benign	0.00
R9342:Vmn2r97	UTSW	17	19,149,368 (GRCm39)	missense	probably benign
R9422:Vmn2r97	UTSW	17	19,149,333 (GRCm39)	missense	probably benign	0.03
R9496:Vmn2r97	UTSW	17	19,149,227 (GRCm39)	missense	probably damaging	1.00
R9571:Vmn2r97	UTSW	17	19,149,919 (GRCm39)	missense	probably benign
R9601:Vmn2r97	UTSW	17	19,134,770 (GRCm39)	missense	probably benign
R9672:Vmn2r97	UTSW	17	19,149,442 (GRCm39)	missense	probably benign	0.00
R9773:Vmn2r97	UTSW	17	19,168,221 (GRCm39)	missense	probably benign	0.01
R9795:Vmn2r97	UTSW	17	19,167,561 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02