Incidental Mutation 'IGL03232:Olfr1445'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1445
Ensembl Gene ENSMUSG00000045126
Gene Nameolfactory receptor 1445
SynonymsGA_x6K02T2RE5P-3213352-3214296, MOR202-7
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.108) question?
Stock #IGL03232
Quality Score
Chromosomal Location12883855-12884855 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 12884272 bp
Amino Acid Change Tyrosine to Stop codon at position 130 (Y130*)
Ref Sequence ENSEMBL: ENSMUSP00000058933 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049624] [ENSMUST00000216805]
Predicted Effect probably null
Transcript: ENSMUST00000049624
AA Change: Y130*
SMART Domains Protein: ENSMUSP00000058933
Gene: ENSMUSG00000045126
AA Change: Y130*

Pfam:7tm_4 29 306 1.7e-54 PFAM
Pfam:7tm_1 39 288 4.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216805
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c19 A G 13: 4,238,463 T147A probably damaging Het
Bdp1 A G 13: 100,051,481 L1532S probably damaging Het
Btbd3 G A 2: 138,284,143 A416T probably damaging Het
Cacna1e C T 1: 154,493,358 R311H probably damaging Het
Cers2 T G 3: 95,320,157 V32G probably damaging Het
Cog4 A G 8: 110,880,682 probably null Het
Crybg3 C A 16: 59,530,368 G870C probably damaging Het
Dmxl1 C T 18: 49,878,180 H1135Y probably benign Het
Esr1 A C 10: 4,969,270 K453N probably damaging Het
Fam166a A T 2: 25,221,739 R277* probably null Het
Gprc5d T C 6: 135,116,664 I82V probably benign Het
Hist1h3c T G 13: 23,745,181 E106A probably damaging Het
Hmcn1 A G 1: 150,770,352 probably benign Het
Loxhd1 A G 18: 77,408,750 T17A probably damaging Het
Lrp1 C T 10: 127,539,376 A4452T probably damaging Het
Morc1 A G 16: 48,630,802 E948G probably benign Het
Mug1 A G 6: 121,878,535 K943E probably benign Het
Olfr1463 T A 19: 13,234,977 C242* probably null Het
Olfr498 A G 7: 108,465,605 T94A probably benign Het
Rab21 T C 10: 115,294,862 probably benign Het
Selenoi T C 5: 30,256,261 F140S probably damaging Het
Serpini1 T C 3: 75,638,010 probably benign Het
Sgip1 T C 4: 102,915,054 probably benign Het
Smc1b T C 15: 85,129,720 I83M possibly damaging Het
Smg7 T C 1: 152,840,156 Y1061C probably damaging Het
Thbs2 A T 17: 14,691,413 M1K probably null Het
Ubqlnl A G 7: 104,148,629 S554P possibly damaging Het
Other mutations in Olfr1445
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Olfr1445 APN 19 12883901 missense probably benign 0.03
IGL01786:Olfr1445 APN 19 12884277 missense probably damaging 0.99
IGL02375:Olfr1445 APN 19 12883941 missense probably benign 0.00
IGL03220:Olfr1445 APN 19 12884451 missense possibly damaging 0.80
R0505:Olfr1445 UTSW 19 12884079 missense probably damaging 1.00
R0505:Olfr1445 UTSW 19 12884546 missense probably damaging 1.00
R0541:Olfr1445 UTSW 19 12884094 missense probably damaging 1.00
R0681:Olfr1445 UTSW 19 12884079 missense probably damaging 1.00
R0681:Olfr1445 UTSW 19 12884546 missense probably damaging 1.00
R2187:Olfr1445 UTSW 19 12884255 missense probably damaging 1.00
R2231:Olfr1445 UTSW 19 12883949 missense probably benign 0.00
R3706:Olfr1445 UTSW 19 12883896 missense probably damaging 1.00
R4698:Olfr1445 UTSW 19 12884621 missense probably benign 0.08
R5558:Olfr1445 UTSW 19 12884387 missense probably benign 0.01
R6163:Olfr1445 UTSW 19 12884108 missense probably damaging 1.00
R7057:Olfr1445 UTSW 19 12884642 missense probably damaging 0.98
R7063:Olfr1445 UTSW 19 12884085 missense probably damaging 1.00
R7705:Olfr1445 UTSW 19 12884507 missense probably benign 0.01
R8073:Olfr1445 UTSW 19 12884616 missense probably benign 0.00
Posted On2016-08-02