Incidental Mutation 'IGL03232:Olfr1463'
ID413932
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1463
Ensembl Gene ENSMUSG00000096365
Gene Nameolfactory receptor 1463
SynonymsMOR202-29P, GA_x6K02T2RE5P-3560863-3561795
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock #IGL03232
Quality Score
Status
Chromosome19
Chromosomal Location13231328-13236400 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 13234977 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 242 (C242*)
Ref Sequence ENSEMBL: ENSMUSP00000146566 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064102] [ENSMUST00000207246]
Predicted Effect probably null
Transcript: ENSMUST00000064102
AA Change: C242*
SMART Domains Protein: ENSMUSP00000070872
Gene: ENSMUSG00000096365
AA Change: C242*

DomainStartEndE-ValueType
Pfam:7tm_4 32 310 1e-51 PFAM
Pfam:7TM_GPCR_Srsx 36 306 3.2e-6 PFAM
Pfam:7tm_1 42 291 1.4e-20 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000207246
AA Change: C242*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c19 A G 13: 4,238,463 T147A probably damaging Het
Bdp1 A G 13: 100,051,481 L1532S probably damaging Het
Btbd3 G A 2: 138,284,143 A416T probably damaging Het
Cacna1e C T 1: 154,493,358 R311H probably damaging Het
Cers2 T G 3: 95,320,157 V32G probably damaging Het
Cog4 A G 8: 110,880,682 probably null Het
Crybg3 C A 16: 59,530,368 G870C probably damaging Het
Dmxl1 C T 18: 49,878,180 H1135Y probably benign Het
Esr1 A C 10: 4,969,270 K453N probably damaging Het
Fam166a A T 2: 25,221,739 R277* probably null Het
Gprc5d T C 6: 135,116,664 I82V probably benign Het
Hist1h3c T G 13: 23,745,181 E106A probably damaging Het
Hmcn1 A G 1: 150,770,352 probably benign Het
Loxhd1 A G 18: 77,408,750 T17A probably damaging Het
Lrp1 C T 10: 127,539,376 A4452T probably damaging Het
Morc1 A G 16: 48,630,802 E948G probably benign Het
Mug1 A G 6: 121,878,535 K943E probably benign Het
Olfr1445 C A 19: 12,884,272 Y130* probably null Het
Olfr498 A G 7: 108,465,605 T94A probably benign Het
Rab21 T C 10: 115,294,862 probably benign Het
Selenoi T C 5: 30,256,261 F140S probably damaging Het
Serpini1 T C 3: 75,638,010 probably benign Het
Sgip1 T C 4: 102,915,054 probably benign Het
Smc1b T C 15: 85,129,720 I83M possibly damaging Het
Smg7 T C 1: 152,840,156 Y1061C probably damaging Het
Thbs2 A T 17: 14,691,413 M1K probably null Het
Ubqlnl A G 7: 104,148,629 S554P possibly damaging Het
Other mutations in Olfr1463
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01131:Olfr1463 APN 19 13234739 missense probably benign 0.01
IGL02596:Olfr1463 APN 19 13234399 missense probably damaging 1.00
IGL03030:Olfr1463 APN 19 13235054 missense probably damaging 0.98
IGL03380:Olfr1463 APN 19 13235001 missense probably benign 0.00
PIT4382001:Olfr1463 UTSW 19 13234895 missense probably damaging 1.00
PIT4519001:Olfr1463 UTSW 19 13234852 missense probably benign 0.00
R0652:Olfr1463 UTSW 19 13234535 missense possibly damaging 0.80
R0658:Olfr1463 UTSW 19 13235060 missense possibly damaging 0.94
R1181:Olfr1463 UTSW 19 13234831 missense probably benign 0.07
R1239:Olfr1463 UTSW 19 13234676 missense possibly damaging 0.80
R1316:Olfr1463 UTSW 19 13234439 missense probably damaging 1.00
R1465:Olfr1463 UTSW 19 13234901 missense possibly damaging 0.61
R1465:Olfr1463 UTSW 19 13234901 missense possibly damaging 0.61
R1900:Olfr1463 UTSW 19 13234913 missense possibly damaging 0.54
R1927:Olfr1463 UTSW 19 13235029 missense probably damaging 1.00
R2239:Olfr1463 UTSW 19 13234721 missense probably benign 0.00
R2380:Olfr1463 UTSW 19 13234721 missense probably benign 0.00
R3760:Olfr1463 UTSW 19 13234886 missense probably damaging 1.00
R3765:Olfr1463 UTSW 19 13234431 missense probably damaging 1.00
R3835:Olfr1463 UTSW 19 13234739 missense probably benign 0.18
R4690:Olfr1463 UTSW 19 13234768 missense possibly damaging 0.91
R4907:Olfr1463 UTSW 19 13234793 missense probably damaging 1.00
R5444:Olfr1463 UTSW 19 13234958 missense probably benign 0.28
R5465:Olfr1463 UTSW 19 13234688 missense probably benign 0.00
R6083:Olfr1463 UTSW 19 13234525 missense probably benign 0.01
R6259:Olfr1463 UTSW 19 13234421 missense probably damaging 0.98
R6324:Olfr1463 UTSW 19 13235104 missense possibly damaging 0.95
R6561:Olfr1463 UTSW 19 13235030 missense probably damaging 1.00
R6845:Olfr1463 UTSW 19 13234633 missense probably damaging 1.00
R7260:Olfr1463 UTSW 19 13235024 missense probably damaging 0.98
R7843:Olfr1463 UTSW 19 13234537 missense possibly damaging 0.48
X0063:Olfr1463 UTSW 19 13234635 missense probably damaging 1.00
X0067:Olfr1463 UTSW 19 13234697 missense possibly damaging 0.95
Posted On2016-08-02