Incidental Mutation 'IGL03235:Vmn1r8'
| ID |
414017 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r8
|
| Ensembl Gene |
ENSMUSG00000061208 |
| Gene Name |
vomeronasal 1 receptor 8 |
| Synonyms |
V1rc32 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
IGL03235
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
57012898-57014110 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 57013746 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 266
(K266*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154298
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078186]
[ENSMUST00000227706]
[ENSMUST00000228690]
|
| AlphaFold |
Q8R2C2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000078186
AA Change: K266*
|
| SMART Domains |
Protein: ENSMUSP00000093561
Gene: ENSMUSG00000061208
AA Change: K266*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
1.2e-58 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000227706
AA Change: K266*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000228690
AA Change: K266*
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ap2b1 |
A |
G |
11: 83,232,210 (GRCm39) |
N461S |
probably benign |
Het |
| Baz1a |
A |
T |
12: 54,945,320 (GRCm39) |
V1345E |
probably damaging |
Het |
| Ccdc60 |
T |
A |
5: 116,269,205 (GRCm39) |
M472L |
probably benign |
Het |
| Cenpf |
C |
T |
1: 189,416,124 (GRCm39) |
R67K |
probably damaging |
Het |
| Cfap45 |
A |
T |
1: 172,366,060 (GRCm39) |
R304S |
possibly damaging |
Het |
| D5Ertd579e |
T |
A |
5: 36,776,172 (GRCm39) |
|
probably benign |
Het |
| Eefsec |
T |
C |
6: 88,353,357 (GRCm39) |
D104G |
probably damaging |
Het |
| Eif2ak4 |
A |
G |
2: 118,273,621 (GRCm39) |
S849G |
probably damaging |
Het |
| Frem1 |
G |
A |
4: 82,938,992 (GRCm39) |
T30I |
possibly damaging |
Het |
| Glt28d2 |
A |
T |
3: 85,779,109 (GRCm39) |
H121Q |
possibly damaging |
Het |
| Hacl1 |
C |
T |
14: 31,352,995 (GRCm39) |
W106* |
probably null |
Het |
| Marchf6 |
A |
G |
15: 31,486,141 (GRCm39) |
S376P |
probably damaging |
Het |
| Mkrn1 |
T |
C |
6: 39,378,264 (GRCm39) |
Y289C |
probably damaging |
Het |
| Msl2 |
A |
G |
9: 100,977,967 (GRCm39) |
T114A |
probably benign |
Het |
| Ntrk3 |
C |
A |
7: 77,842,340 (GRCm39) |
K829N |
probably damaging |
Het |
| Or4b1d |
A |
T |
2: 89,969,414 (GRCm39) |
V23E |
possibly damaging |
Het |
| Pcdhgc5 |
A |
T |
18: 37,953,151 (GRCm39) |
I142F |
probably damaging |
Het |
| Pip5kl1 |
A |
G |
2: 32,468,166 (GRCm39) |
R153G |
probably damaging |
Het |
| Rgs19 |
T |
C |
2: 181,331,525 (GRCm39) |
K93R |
probably benign |
Het |
| Slc36a4 |
T |
A |
9: 15,634,845 (GRCm39) |
V129E |
probably damaging |
Het |
| Spata13 |
T |
C |
14: 60,989,241 (GRCm39) |
L299P |
probably damaging |
Het |
| Tle2 |
T |
C |
10: 81,422,085 (GRCm39) |
S353P |
probably benign |
Het |
| Trav13d-4 |
T |
C |
14: 53,995,298 (GRCm39) |
V84A |
probably benign |
Het |
| Wwtr1 |
C |
A |
3: 57,384,954 (GRCm39) |
V255F |
probably benign |
Het |
|
| Other mutations in Vmn1r8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01569:Vmn1r8
|
APN |
6 |
57,013,272 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL01820:Vmn1r8
|
APN |
6 |
57,013,653 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02416:Vmn1r8
|
APN |
6 |
57,013,605 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02496:Vmn1r8
|
APN |
6 |
57,013,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02930:Vmn1r8
|
APN |
6 |
57,013,579 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02954:Vmn1r8
|
APN |
6 |
57,013,315 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03353:Vmn1r8
|
APN |
6 |
57,013,776 (GRCm39) |
missense |
probably benign |
0.03 |
|
PIT4494001:Vmn1r8
|
UTSW |
6 |
57,013,712 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0656:Vmn1r8
|
UTSW |
6 |
57,013,573 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1328:Vmn1r8
|
UTSW |
6 |
57,013,278 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1846:Vmn1r8
|
UTSW |
6 |
57,013,413 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2083:Vmn1r8
|
UTSW |
6 |
57,013,325 (GRCm39) |
missense |
probably benign |
0.21 |
|
R3683:Vmn1r8
|
UTSW |
6 |
57,013,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4134:Vmn1r8
|
UTSW |
6 |
57,013,705 (GRCm39) |
missense |
probably benign |
|
|
R4754:Vmn1r8
|
UTSW |
6 |
57,012,952 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R4857:Vmn1r8
|
UTSW |
6 |
57,013,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5787:Vmn1r8
|
UTSW |
6 |
57,013,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6158:Vmn1r8
|
UTSW |
6 |
57,013,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6711:Vmn1r8
|
UTSW |
6 |
57,013,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6971:Vmn1r8
|
UTSW |
6 |
57,013,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8066:Vmn1r8
|
UTSW |
6 |
57,013,419 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8261:Vmn1r8
|
UTSW |
6 |
57,013,158 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8526:Vmn1r8
|
UTSW |
6 |
57,013,362 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8552:Vmn1r8
|
UTSW |
6 |
57,013,138 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8692:Vmn1r8
|
UTSW |
6 |
57,013,557 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8712:Vmn1r8
|
UTSW |
6 |
57,013,665 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9306:Vmn1r8
|
UTSW |
6 |
57,013,713 (GRCm39) |
missense |
probably benign |
0.12 |
|
| Posted On |
2016-08-02 |
Incidental Mutation