Incidental Mutation 'IGL03235:Trav13-4-dv7'
ID414019
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trav13-4-dv7
Ensembl Gene ENSMUSG00000094562
Gene NameT cell receptor alpha variable 13-4-DV7
SynonymsGm13934
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL03235
Quality Score
Status
Chromosome14
Chromosomal Location53757356-53757920 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 53757841 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 84 (V84A)
Ref Sequence ENSEMBL: ENSMUSP00000137919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000180380] [ENSMUST00000184905]
Predicted Effect probably benign
Transcript: ENSMUST00000180380
AA Change: V84A

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000137919
Gene: ENSMUSG00000094562
AA Change: V84A

DomainStartEndE-ValueType
low complexity region 4 13 N/A INTRINSIC
IGv 38 109 2.89e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000184905
AA Change: V64A

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000138894
Gene: ENSMUSG00000094562
AA Change: V64A

DomainStartEndE-ValueType
Pfam:V-set 1 88 4.1e-17 PFAM
Pfam:I-set 2 88 1.9e-8 PFAM
Pfam:Ig_2 3 88 8e-7 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap2b1 A G 11: 83,341,384 N461S probably benign Het
Baz1a A T 12: 54,898,535 V1345E probably damaging Het
Ccdc60 T A 5: 116,131,146 M472L probably benign Het
Cenpf C T 1: 189,683,927 R67K probably damaging Het
Cfap45 A T 1: 172,538,493 R304S possibly damaging Het
D5Ertd579e T A 5: 36,618,828 probably benign Het
Eefsec T C 6: 88,376,375 D104G probably damaging Het
Eif2ak4 A G 2: 118,443,140 S849G probably damaging Het
Frem1 G A 4: 83,020,755 T30I possibly damaging Het
Glt28d2 A T 3: 85,871,802 H121Q possibly damaging Het
Hacl1 C T 14: 31,631,038 W106* probably null Het
March6 A G 15: 31,485,995 S376P probably damaging Het
Mkrn1 T C 6: 39,401,330 Y289C probably damaging Het
Msl2 A G 9: 101,100,768 T114A probably benign Het
Ntrk3 C A 7: 78,192,592 K829N probably damaging Het
Olfr32 A T 2: 90,139,070 V23E possibly damaging Het
Pcdhgc5 A T 18: 37,820,098 I142F probably damaging Het
Pip5kl1 A G 2: 32,578,154 R153G probably damaging Het
Rgs19 T C 2: 181,689,732 K93R probably benign Het
Slc36a4 T A 9: 15,723,549 V129E probably damaging Het
Spata13 T C 14: 60,751,792 L299P probably damaging Het
Tle2 T C 10: 81,586,251 S353P probably benign Het
Vmn1r8 A T 6: 57,036,761 K266* probably null Het
Wwtr1 C A 3: 57,477,533 V255F probably benign Het
Other mutations in Trav13-4-dv7
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4382001:Trav13-4-dv7 UTSW 14 53757781 missense probably benign 0.34
R6372:Trav13-4-dv7 UTSW 14 53757661 missense probably damaging 0.99
R7714:Trav13-4-dv7 UTSW 14 53757898 missense probably damaging 1.00
R8070:Trav13-4-dv7 UTSW 14 53757792 missense possibly damaging 0.47
Posted On2016-08-02