Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03238:Tmem101'

414183

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem101

Ensembl Gene

ENSMUSG00000020921

Gene Name

transmembrane protein 101

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

IGL03238

Quality Score

Status

Chromosome

Chromosomal Location

102152546-102156404 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 102155785 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 86 (L86Q)

Ref Sequence

ENSEMBL: ENSMUSP00000021296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021296]

AlphaFold

Q91VP7

Predicted Effect

probably damaging
Transcript: ENSMUST00000021296
AA Change: L86Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000021296
Gene: ENSMUSG00000020921
AA Change: L86Q

Domain	Start	End	E-Value	Type
Pfam:TMEM101	8	256	9.9e-122	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136434

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143986

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2	A	C	3: 60,024,918	T285P	probably benign	Het
Abcf1	T	C	17: 35,963,323	K186E	probably damaging	Het
Adam3	T	C	8: 24,687,965		probably null	Het
Art1	T	C	7: 102,110,749	V85A	possibly damaging	Het
Ccdc110	A	G	8: 45,941,822	H250R	probably benign	Het
Cyp3a13	T	A	5: 137,898,889	I388F	probably damaging	Het
Dnah11	C	T	12: 118,109,898	V1425M	probably damaging	Het
Donson	G	A	16: 91,681,246	Q22*	probably null	Het
Eif2b2	A	G	12: 85,223,399	T238A	probably benign	Het
Emc2	T	A	15: 43,507,853		probably null	Het
Fkbp4	A	T	6: 128,434,757	V123E	probably damaging	Het
Frem2	A	T	3: 53,656,261	M275K	possibly damaging	Het
Gcat	T	A	15: 79,036,010		probably benign	Het
Gemin2	G	A	12: 59,016,962		probably benign	Het
Ilf3	T	A	9: 21,392,350	V169E	probably damaging	Het
Klra17	T	C	6: 129,868,810	H147R	probably benign	Het
Lama5	A	G	2: 180,188,574	I1880T	probably benign	Het
Lzts1	T	C	8: 69,138,794	D234G	probably damaging	Het
Map3k4	G	A	17: 12,271,158	P462L	probably benign	Het
March6	C	A	15: 31,461,941		probably benign	Het
Mcm6	A	T	1: 128,355,520	F83I	probably benign	Het
Mtpn	A	G	6: 35,522,773	L32P	probably damaging	Het
Mybpc3	A	T	2: 91,131,659	I841F	probably damaging	Het
Ndst2	G	T	14: 20,728,504	H399N	probably damaging	Het
Npat	G	T	9: 53,570,426	V1145F	probably damaging	Het
Olfr65	G	A	7: 103,906,510	A21T	probably benign	Het
P2ry1	T	A	3: 61,004,495	S352T	probably damaging	Het
Plaa	T	C	4: 94,583,896	T326A	probably benign	Het
Ppdpf	T	C	2: 181,187,880	S43P	probably benign	Het
Prpmp5	T	A	6: 132,312,345	Q172L	unknown	Het
Setd1a	C	T	7: 127,785,546	T523I	possibly damaging	Het
Sgcz	C	T	8: 37,563,140		probably null	Het
Slc12a2	T	C	18: 57,914,234	Y740H	possibly damaging	Het
Stab2	A	G	10: 86,855,121	C745R	probably damaging	Het
Tmtc3	A	C	10: 100,477,840	F57V	probably damaging	Het
Vps50	A	G	6: 3,594,771	K778R	possibly damaging	Het
Washc5	G	A	15: 59,346,842	T692M	probably damaging	Het
Zc3hav1	A	T	6: 38,332,750	V379D	probably damaging	Het
Zfp142	G	T	1: 74,576,278	R459S	probably benign	Het
Zfp512b	A	G	2: 181,589,760	V199A	probably damaging	Het

Other mutations in Tmem101

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01085:Tmem101	APN	11	102154660	missense	probably damaging	0.99
IGL01096:Tmem101	APN	11	102154552	splice site	probably null
IGL01593:Tmem101	APN	11	102155878	missense	probably damaging	1.00
IGL01814:Tmem101	APN	11	102153458	missense	possibly damaging	0.58
IGL02451:Tmem101	APN	11	102153293	missense	probably damaging	1.00
R0462:Tmem101	UTSW	11	102155867	missense	probably benign	0.08
R0848:Tmem101	UTSW	11	102155866	missense	possibly damaging	0.65
R1465:Tmem101	UTSW	11	102153329	missense	probably damaging	0.97
R1465:Tmem101	UTSW	11	102153329	missense	probably damaging	0.97
R1722:Tmem101	UTSW	11	102154693	missense	probably damaging	1.00
R1928:Tmem101	UTSW	11	102153396	missense	probably benign
R2082:Tmem101	UTSW	11	102153377	missense	probably benign	0.17
R4577:Tmem101	UTSW	11	102155837	missense	possibly damaging	0.48
R4724:Tmem101	UTSW	11	102153443	missense	probably benign	0.32
R4729:Tmem101	UTSW	11	102156329	missense	probably benign	0.25
R5146:Tmem101	UTSW	11	102154624	missense	probably benign
R5184:Tmem101	UTSW	11	102156233	missense	possibly damaging	0.78
R7381:Tmem101	UTSW	11	102153350	missense	possibly damaging	0.91
R8799:Tmem101	UTSW	11	102153510	missense	probably benign	0.08
R9612:Tmem101	UTSW	11	102153368	missense	probably damaging	1.00

Posted On

2016-08-02