Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03239:Olfm3'

414201

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfm3

Ensembl Gene

ENSMUSG00000027965

Gene Name

olfactomedin 3

Synonyms

optimedin, B230206G02Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.119) question?

Stock #

IGL03239

Quality Score

Status

Chromosome

Chromosomal Location

114904078-115125722 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 115122594 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 392 (R392G)

Ref Sequence

ENSEMBL: ENSMUSP00000060985 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051309] [ENSMUST00000081752] [ENSMUST00000149158]

Predicted Effect

probably damaging
Transcript: ENSMUST00000051309
AA Change: R392G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000060985
Gene: ENSMUSG00000027965
AA Change: R392G

Domain	Start	End	E-Value	Type
signal peptide	1	16	N/A	INTRINSIC
Pfam:Noelin-1	46	145	3.9e-52	PFAM
Blast:OLF	162	207	3e-8	BLAST
OLF	220	470	4.33e-114	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000081752
AA Change: R372G

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000080448
Gene: ENSMUSG00000027965
AA Change: R372G

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:Noelin-1	25	125	7.6e-54	PFAM
Blast:OLF	142	187	3e-8	BLAST
OLF	200	450	4.33e-114	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000149158

SMART Domains

Protein: ENSMUSP00000121097
Gene: ENSMUSG00000027965

Domain	Start	End	E-Value	Type
Pfam:Noelin-1	12	112	2.5e-51	PFAM
Blast:OLF	129	174	1e-8	BLAST
Blast:OLF	187	210	1e-7	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930011G23Rik	T	C	5: 99,233,976	Y309C	probably damaging	Het
Arvcf	G	T	16: 18,397,067	V44L	probably damaging	Het
Catsperg2	T	G	7: 29,697,716	S1121R	probably benign	Het
Ccdc190	G	T	1: 169,933,980	R217L	probably benign	Het
Chd8	G	A	14: 52,227,548	P619S	possibly damaging	Het
Cyp17a1	A	T	19: 46,667,357	W498R	probably damaging	Het
Dgka	A	G	10: 128,721,385		probably benign	Het
Ep300	A	G	15: 81,641,388	D1471G	unknown	Het
Htr2b	A	G	1: 86,099,692	F364S	probably damaging	Het
Kcnv1	A	G	15: 45,109,490		probably benign	Het
Lrrc37a	T	C	11: 103,499,407	T1731A	probably benign	Het
Mylip	A	G	13: 45,406,625	E179G	possibly damaging	Het
Pbk	T	A	14: 65,817,218	D266E	probably benign	Het
Pcdhb13	C	A	18: 37,442,835	L89M	probably damaging	Het
Prdm5	T	G	6: 65,886,078		probably benign	Het
Rab3gap2	A	G	1: 185,249,894	D381G	probably damaging	Het
Sec24d	A	G	3: 123,336,489	N434D	probably benign	Het
Tmem246	T	C	4: 49,586,034	Y378C	probably damaging	Het
Usp17la	C	T	7: 104,860,620	T144I	possibly damaging	Het
Usp35	T	C	7: 97,321,592	T336A	possibly damaging	Het

Other mutations in Olfm3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01656:Olfm3	APN	3	115122633	missense	probably damaging	1.00
IGL01686:Olfm3	APN	3	115122848	missense	probably benign	0.00
IGL01732:Olfm3	APN	3	115097000	missense	possibly damaging	0.82
IGL02539:Olfm3	APN	3	115101930	missense	possibly damaging	0.93
IGL02580:Olfm3	APN	3	115122508	missense	probably damaging	1.00
IGL02999:Olfm3	APN	3	115122748	missense	probably damaging	1.00
IGL03142:Olfm3	APN	3	115097030	missense	probably damaging	0.97
R0361:Olfm3	UTSW	3	115120973	missense	probably damaging	1.00
R0373:Olfm3	UTSW	3	115122805	missense	probably damaging	0.99
R0505:Olfm3	UTSW	3	115122681	missense	possibly damaging	0.46
R0689:Olfm3	UTSW	3	115122545	missense	probably benign	0.28
R0973:Olfm3	UTSW	3	115101986	missense	probably benign	0.00
R0973:Olfm3	UTSW	3	115101986	missense	probably benign	0.00
R0974:Olfm3	UTSW	3	115101986	missense	probably benign	0.00
R1253:Olfm3	UTSW	3	115122769	missense	probably damaging	0.98
R1293:Olfm3	UTSW	3	115101930	missense	possibly damaging	0.93
R1952:Olfm3	UTSW	3	115101940	missense	probably null	1.00
R2255:Olfm3	UTSW	3	115122193	unclassified	probably null
R2334:Olfm3	UTSW	3	115101959	nonsense	probably null
R2510:Olfm3	UTSW	3	115122310	missense	probably damaging	1.00
R4222:Olfm3	UTSW	3	115090171	nonsense	probably null
R4716:Olfm3	UTSW	3	115081106	missense	probably benign	0.00
R4912:Olfm3	UTSW	3	115101940	missense	probably damaging	1.00
R5084:Olfm3	UTSW	3	114904553	critical splice donor site	probably null
R5649:Olfm3	UTSW	3	115096924	missense	probably damaging	0.99
R5681:Olfm3	UTSW	3	115122275	missense	probably benign	0.28
R5861:Olfm3	UTSW	3	115122403	missense	probably damaging	1.00
R5924:Olfm3	UTSW	3	115122538	missense	probably benign	0.44
R5929:Olfm3	UTSW	3	115101880	missense	probably damaging	0.97
R5958:Olfm3	UTSW	3	115122306	missense	probably damaging	0.99
R6166:Olfm3	UTSW	3	115122425	missense	probably damaging	1.00
R6299:Olfm3	UTSW	3	115120983	missense	probably damaging	1.00
R6804:Olfm3	UTSW	3	115122679	missense	probably benign	0.10
R7032:Olfm3	UTSW	3	115090156	missense	probably damaging	1.00
R7565:Olfm3	UTSW	3	115122744	missense	probably damaging	0.98
R7600:Olfm3	UTSW	3	115096940	missense	possibly damaging	0.65
R8070:Olfm3	UTSW	3	115101955	missense	probably damaging	0.96
Z1088:Olfm3	UTSW	3	114904668	start gained	probably benign
Z1177:Olfm3	UTSW	3	115081101	missense	probably benign	0.01

Posted On

2016-08-02