Incidental Mutation 'IGL03243:Zfp385c'
ID414315
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp385c
Ensembl Gene ENSMUSG00000014198
Gene Namezinc finger protein 385C
SynonymsA930006D11Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.225) question?
Stock #IGL03243
Quality Score
Status
Chromosome11
Chromosomal Location100627543-100692455 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 100634747 bp
ZygosityHeterozygous
Amino Acid Change Valine to Aspartic acid at position 56 (V56D)
Ref Sequence ENSEMBL: ENSMUSP00000099408 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103119] [ENSMUST00000153494]
Predicted Effect probably damaging
Transcript: ENSMUST00000103119
AA Change: V56D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000099408
Gene: ENSMUSG00000014198
AA Change: V56D

DomainStartEndE-ValueType
low complexity region 2 24 N/A INTRINSIC
ZnF_U1 72 108 4.36e-2 SMART
ZnF_C2H2 77 99 1.51e0 SMART
low complexity region 125 141 N/A INTRINSIC
low complexity region 143 161 N/A INTRINSIC
low complexity region 181 200 N/A INTRINSIC
ZnF_U1 225 259 5.72e-4 SMART
ZnF_C2H2 228 252 7.11e0 SMART
ZnF_U1 294 328 7.44e-3 SMART
ZnF_C2H2 297 321 4.34e0 SMART
low complexity region 347 365 N/A INTRINSIC
low complexity region 382 405 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148560
Predicted Effect unknown
Transcript: ENSMUST00000151589
AA Change: V135D
SMART Domains Protein: ENSMUSP00000119259
Gene: ENSMUSG00000014198
AA Change: V135D

DomainStartEndE-ValueType
ZnF_U1 40 74 6.04e-3 SMART
ZnF_C2H2 43 67 6.31e1 SMART
low complexity region 79 104 N/A INTRINSIC
ZnF_U1 152 188 4.36e-2 SMART
ZnF_C2H2 157 179 1.51e0 SMART
low complexity region 205 221 N/A INTRINSIC
low complexity region 223 241 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000153494
SMART Domains Protein: ENSMUSP00000115268
Gene: ENSMUSG00000014198

DomainStartEndE-ValueType
Pfam:zf-met 42 67 6.4e-8 PFAM
low complexity region 79 102 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26a T C 8: 43,568,696 T586A probably benign Het
Agtr1b T C 3: 20,315,795 T216A probably benign Het
Ankdd1a T C 9: 65,501,470 R505G probably benign Het
Anxa3 A T 5: 96,828,692 probably benign Het
Atp6v1c2 C T 12: 17,289,121 V210I probably benign Het
BC034090 G A 1: 155,225,655 P288S possibly damaging Het
Catsper2 T C 2: 121,406,819 H200R probably benign Het
Cntnap5c G T 17: 58,102,176 A470S probably benign Het
Fcho2 G A 13: 98,777,384 probably benign Het
Frem1 A C 4: 83,013,969 L165R probably damaging Het
Gm5155 A T 7: 17,918,649 noncoding transcript Het
Gpn1 G A 5: 31,510,831 probably null Het
Gpr179 T C 11: 97,351,475 N181S probably benign Het
Heatr5b A T 17: 78,763,080 probably benign Het
Kat6a A G 8: 22,910,222 N333S possibly damaging Het
Lrp5 T C 19: 3,630,159 T442A probably benign Het
Myo15 G T 11: 60,496,518 L722F probably damaging Het
Nlrp9c T G 7: 26,365,032 D957A probably damaging Het
Nupl1 T A 14: 60,221,616 T521S probably benign Het
Olfr58 T G 9: 19,783,268 I45S probably damaging Het
Plek C A 11: 16,995,319 V4L possibly damaging Het
Sell T A 1: 164,065,342 H42Q possibly damaging Het
Slfn8 A T 11: 83,003,707 I702K probably damaging Het
Svep1 T C 4: 58,133,387 I573V probably benign Het
Tgm1 T A 14: 55,705,907 I526F probably damaging Het
Tmem30c A T 16: 57,276,150 S203T probably benign Het
Tox T C 4: 6,697,597 N402S possibly damaging Het
Trav7d-4 C A 14: 52,770,098 probably benign Het
Unc13d A T 11: 116,067,844 V784D probably benign Het
Vmn2r68 A G 7: 85,233,755 V263A possibly damaging Het
Znrf2 A T 6: 54,884,769 I222L possibly damaging Het
Other mutations in Zfp385c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02156:Zfp385c APN 11 100629019 missense probably damaging 1.00
IGL02542:Zfp385c APN 11 100629916 missense probably damaging 1.00
IGL02579:Zfp385c APN 11 100630779 missense probably damaging 1.00
R0054:Zfp385c UTSW 11 100629956 missense probably benign 0.08
R0054:Zfp385c UTSW 11 100629956 missense probably benign 0.08
R1158:Zfp385c UTSW 11 100629883 unclassified probably benign
R1884:Zfp385c UTSW 11 100630706 missense probably benign
R1892:Zfp385c UTSW 11 100637804 missense probably damaging 1.00
R6010:Zfp385c UTSW 11 100657537 missense probably benign 0.00
R6020:Zfp385c UTSW 11 100632768 missense probably benign
R6901:Zfp385c UTSW 11 100632759 missense probably benign 0.06
R7008:Zfp385c UTSW 11 100630687 missense probably damaging 0.99
R7272:Zfp385c UTSW 11 100630039 missense possibly damaging 0.50
Z1177:Zfp385c UTSW 11 100637773 missense probably damaging 1.00
Z1177:Zfp385c UTSW 11 100657431 missense probably damaging 0.99
Posted On2016-08-02