Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03244:Vmn2r53'

414334

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r53

Ensembl Gene

ENSMUSG00000096002

Gene Name

vomeronasal 2, receptor 53

Synonyms

EG637908

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

IGL03244

Quality Score

Status

Chromosome

Chromosomal Location

12315397-12342583 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 12340435 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Serine at position 13 (A13S)

Ref Sequence

ENSEMBL: ENSMUSP00000126979 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170412]

AlphaFold

A0A3B2W4A7

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000118665

Predicted Effect

probably damaging
Transcript: ENSMUST00000170412
AA Change: A13S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000126979
Gene: ENSMUSG00000096002
AA Change: A13S

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	5	397	3.6e-58	PFAM
Pfam:NCD3G	442	495	2.2e-19	PFAM
Pfam:7tm_3	526	763	3.1e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ank2	C	A	3: 126,749,519 (GRCm39)	E503D	probably damaging	Het
Aoc1	T	C	6: 48,882,756 (GRCm39)	Y233H	possibly damaging	Het
Apaf1	A	T	10: 90,885,211 (GRCm39)		probably benign	Het
Asah2	T	C	19: 31,964,342 (GRCm39)	Y696C	probably damaging	Het
Atp8b3	A	T	10: 80,370,292 (GRCm39)	D112E	probably damaging	Het
B3gat3	T	C	19: 8,903,215 (GRCm39)	Y191H	probably damaging	Het
Capns2	T	C	8: 93,628,738 (GRCm39)	I209T	probably damaging	Het
Ccnl2	T	C	4: 155,905,479 (GRCm39)	I303T	probably benign	Het
Cdk5rap2	A	T	4: 70,199,672 (GRCm39)	S817R	probably benign	Het
Cep57	A	T	9: 13,729,683 (GRCm39)	L36*	probably null	Het
Cers4	T	A	8: 4,566,878 (GRCm39)	V60E	probably damaging	Het
Ces2e	T	C	8: 105,655,451 (GRCm39)	Y125H	probably benign	Het
Cyp4f18	T	C	8: 72,742,489 (GRCm39)	E497G	probably benign	Het
Ddx24	A	T	12: 103,383,864 (GRCm39)	M575K	possibly damaging	Het
Dmxl2	A	T	9: 54,323,655 (GRCm39)	V1243E	probably damaging	Het
Elf2	A	T	3: 51,165,193 (GRCm39)	Y270*	probably null	Het
Ep400	A	G	5: 110,875,429 (GRCm39)	L844S	unknown	Het
F13a1	A	T	13: 37,172,870 (GRCm39)	I170N	possibly damaging	Het
Gm16506	T	A	14: 43,961,603 (GRCm39)		probably benign	Het
Grm4	A	G	17: 27,653,797 (GRCm39)	F463L	probably damaging	Het
H2-M10.2	A	T	17: 36,596,463 (GRCm39)	N127K	probably benign	Het
Lrrc49	T	C	9: 60,495,140 (GRCm39)	Y691C	probably damaging	Het
Mbip	A	C	12: 56,384,547 (GRCm39)		probably null	Het
Or9k2	T	A	10: 129,998,269 (GRCm39)	K309*	probably null	Het
Plod1	C	T	4: 148,007,580 (GRCm39)		probably null	Het
Primpol	A	G	8: 47,039,475 (GRCm39)	W382R	probably damaging	Het
Rufy2	A	G	10: 62,840,483 (GRCm39)	E418G	probably benign	Het
Samm50	T	C	15: 84,098,341 (GRCm39)	V460A	probably benign	Het
Senp2	T	C	16: 21,859,329 (GRCm39)	V460A	probably damaging	Het
Simc1	A	G	13: 54,698,442 (GRCm39)	H453R	probably benign	Het
Slc22a22	A	G	15: 57,112,948 (GRCm39)		probably benign	Het
Spag1	A	T	15: 36,234,529 (GRCm39)	D763V	probably benign	Het
Thsd7a	T	A	6: 12,504,167 (GRCm39)		probably benign	Het
Tppp	G	T	13: 74,169,535 (GRCm39)	V92F	possibly damaging	Het
Vmn1r32	G	A	6: 66,530,489 (GRCm39)	L96F	probably damaging	Het
Vmn2r75	G	A	7: 85,820,933 (GRCm39)		probably benign	Het
Zfp750	C	A	11: 121,404,513 (GRCm39)	G121*	probably null	Het

Other mutations in Vmn2r53

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01090:Vmn2r53	APN	7	12,334,835 (GRCm39)	missense	possibly damaging	0.70
IGL01997:Vmn2r53	APN	7	12,316,373 (GRCm39)	missense	possibly damaging	0.54
IGL02442:Vmn2r53	APN	7	12,315,656 (GRCm39)	missense	probably damaging	1.00
IGL02449:Vmn2r53	APN	7	12,316,288 (GRCm39)	missense	probably damaging	1.00
IGL02589:Vmn2r53	APN	7	12,315,872 (GRCm39)	missense	possibly damaging	0.93
IGL02986:Vmn2r53	APN	7	12,315,393 (GRCm39)	unclassified	probably benign
IGL03064:Vmn2r53	APN	7	12,334,937 (GRCm39)	missense	possibly damaging	0.89
IGL03093:Vmn2r53	APN	7	12,334,791 (GRCm39)	missense	probably benign	0.03
IGL03252:Vmn2r53	APN	7	12,340,318 (GRCm39)	missense	probably damaging	1.00
IGL03264:Vmn2r53	APN	7	12,315,819 (GRCm39)	missense	possibly damaging	0.95
IGL03293:Vmn2r53	APN	7	12,332,349 (GRCm39)	missense	probably benign	0.34
R0109:Vmn2r53	UTSW	7	12,315,993 (GRCm39)	missense	probably damaging	1.00
R0453:Vmn2r53	UTSW	7	12,316,338 (GRCm39)	missense	probably damaging	1.00
R0735:Vmn2r53	UTSW	7	12,315,707 (GRCm39)	missense	probably benign
R0881:Vmn2r53	UTSW	7	12,334,859 (GRCm39)	missense	probably benign	0.01
R0894:Vmn2r53	UTSW	7	12,335,141 (GRCm39)	missense	probably benign	0.00
R0973:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0973:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0974:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0990:Vmn2r53	UTSW	7	12,315,429 (GRCm39)	missense	probably benign
R1102:Vmn2r53	UTSW	7	12,332,410 (GRCm39)	missense	possibly damaging	0.94
R1141:Vmn2r53	UTSW	7	12,334,673 (GRCm39)	missense	possibly damaging	0.54
R1263:Vmn2r53	UTSW	7	12,315,533 (GRCm39)	missense	probably benign	0.41
R1343:Vmn2r53	UTSW	7	12,318,701 (GRCm39)	missense	probably benign	0.08
R1750:Vmn2r53	UTSW	7	12,315,632 (GRCm39)	missense	probably damaging	1.00
R1836:Vmn2r53	UTSW	7	12,334,812 (GRCm39)	missense	probably damaging	1.00
R2035:Vmn2r53	UTSW	7	12,332,438 (GRCm39)	missense	possibly damaging	0.76
R2202:Vmn2r53	UTSW	7	12,335,366 (GRCm39)	missense	probably damaging	1.00
R3707:Vmn2r53	UTSW	7	12,315,981 (GRCm39)	missense	possibly damaging	0.95
R4372:Vmn2r53	UTSW	7	12,315,656 (GRCm39)	missense	probably damaging	0.98
R4615:Vmn2r53	UTSW	7	12,316,229 (GRCm39)	missense	probably damaging	1.00
R4655:Vmn2r53	UTSW	7	12,315,932 (GRCm39)	missense	possibly damaging	0.83
R4663:Vmn2r53	UTSW	7	12,334,901 (GRCm39)	missense	probably benign	0.21
R4708:Vmn2r53	UTSW	7	12,335,129 (GRCm39)	missense	probably benign
R4710:Vmn2r53	UTSW	7	12,335,129 (GRCm39)	missense	probably benign
R4774:Vmn2r53	UTSW	7	12,334,692 (GRCm39)	nonsense	probably null
R4859:Vmn2r53	UTSW	7	12,335,330 (GRCm39)	missense	probably damaging	1.00
R5061:Vmn2r53	UTSW	7	12,315,741 (GRCm39)	missense	probably benign	0.01
R5561:Vmn2r53	UTSW	7	12,335,347 (GRCm39)	missense	probably damaging	1.00
R5729:Vmn2r53	UTSW	7	12,334,733 (GRCm39)	missense	probably damaging	1.00
R6004:Vmn2r53	UTSW	7	12,316,328 (GRCm39)	missense	probably benign	0.12
R6083:Vmn2r53	UTSW	7	12,315,808 (GRCm39)	missense	probably benign
R6312:Vmn2r53	UTSW	7	12,332,566 (GRCm39)	critical splice acceptor site	probably null
R6700:Vmn2r53	UTSW	7	12,315,633 (GRCm39)	missense	probably damaging	0.96
R6783:Vmn2r53	UTSW	7	12,335,360 (GRCm39)	missense	probably damaging	1.00
R6852:Vmn2r53	UTSW	7	12,340,441 (GRCm39)	missense	probably damaging	0.99
R6889:Vmn2r53	UTSW	7	12,335,069 (GRCm39)	missense	probably benign	0.10
R6940:Vmn2r53	UTSW	7	12,316,343 (GRCm39)	missense	probably benign	0.19
R7100:Vmn2r53	UTSW	7	12,315,513 (GRCm39)	nonsense	probably null
R7174:Vmn2r53	UTSW	7	12,315,628 (GRCm39)	missense	probably benign	0.01
R7213:Vmn2r53	UTSW	7	12,334,983 (GRCm39)	missense	probably benign	0.17
R7276:Vmn2r53	UTSW	7	12,340,359 (GRCm39)	missense	probably damaging	0.99
R7515:Vmn2r53	UTSW	7	12,315,846 (GRCm39)	missense	probably benign	0.05
R7678:Vmn2r53	UTSW	7	12,332,425 (GRCm39)	missense	probably benign	0.04
R7714:Vmn2r53	UTSW	7	12,340,418 (GRCm39)	missense	probably damaging	1.00
R7843:Vmn2r53	UTSW	7	12,316,026 (GRCm39)	missense	probably damaging	1.00
R8208:Vmn2r53	UTSW	7	12,335,322 (GRCm39)	missense	probably damaging	1.00
R8211:Vmn2r53	UTSW	7	12,315,843 (GRCm39)	missense	probably benign	0.01
R8478:Vmn2r53	UTSW	7	12,340,281 (GRCm39)	missense	probably benign	0.01
R8853:Vmn2r53	UTSW	7	12,315,737 (GRCm39)	missense	probably damaging	1.00
R8924:Vmn2r53	UTSW	7	12,334,752 (GRCm39)	missense	probably benign	0.17
R8963:Vmn2r53	UTSW	7	12,315,926 (GRCm39)	missense	probably damaging	1.00
R9042:Vmn2r53	UTSW	7	12,315,435 (GRCm39)	missense	probably benign
R9076:Vmn2r53	UTSW	7	12,340,231 (GRCm39)	missense	probably damaging	1.00
R9407:Vmn2r53	UTSW	7	12,335,124 (GRCm39)	missense	probably damaging	0.99
R9690:Vmn2r53	UTSW	7	12,315,912 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r53	UTSW	7	12,335,231 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02