Incidental Mutation 'IGL03255:Gm10220'
ID414618
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm10220
Ensembl Gene ENSMUSG00000067698
Gene Namepredicted gene 10220
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.437) question?
Stock #IGL03255
Quality Score
Status
Chromosome5
Chromosomal Location26114764-26121421 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 26116901 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 258 (S258P)
Ref Sequence ENSEMBL: ENSMUSP00000085569 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088236]
Predicted Effect possibly damaging
Transcript: ENSMUST00000088236
AA Change: S258P

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000085569
Gene: ENSMUSG00000067698
AA Change: S258P

DomainStartEndE-ValueType
Pfam:Takusan 50 134 1.6e-25 PFAM
low complexity region 235 259 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600012P17Rik A G 1: 158,969,351 noncoding transcript Het
Alpk3 A G 7: 81,092,562 D709G probably benign Het
AY761184 T C 8: 21,703,518 T29A possibly damaging Het
Capn3 G T 2: 120,489,708 R309L probably damaging Het
Card11 T C 5: 140,898,331 I398V possibly damaging Het
Cps1 T A 1: 67,145,801 Y162* probably null Het
Defa26 A T 8: 21,618,241 D20V probably damaging Het
Dnah8 T G 17: 30,741,381 L2244R probably damaging Het
Fhad1 T A 4: 141,972,880 N353I possibly damaging Het
Flt1 T A 5: 147,588,521 probably benign Het
Glyr1 G A 16: 5,048,757 probably null Het
Lama3 A T 18: 12,539,703 D845V probably damaging Het
Myh2 T A 11: 67,193,225 L1558Q probably damaging Het
Nelfb G T 2: 25,203,195 H482N probably benign Het
Olfr290 T C 7: 84,916,517 L246P possibly damaging Het
Olfr482 A G 7: 108,094,817 V251A probably damaging Het
Ppfia2 A G 10: 106,896,507 T972A possibly damaging Het
Slc5a4a G A 10: 76,150,512 V85M probably damaging Het
Slc6a12 T G 6: 121,354,287 C166G probably damaging Het
Tm7sf3 T C 6: 146,606,120 probably benign Het
Tmem94 G T 11: 115,792,068 probably benign Het
Tmod2 T C 9: 75,577,258 probably benign Het
Tmprss11c T A 5: 86,271,482 I73F probably damaging Het
Vmn1r10 A G 6: 57,113,926 M168V probably benign Het
Vmn2r77 T A 7: 86,811,923 M819K probably benign Het
Vmo1 C T 11: 70,514,410 probably null Het
Ywhab A G 2: 164,014,016 D104G probably benign Het
Other mutations in Gm10220
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00401:Gm10220 APN 5 26118611 missense possibly damaging 0.94
IGL01782:Gm10220 APN 5 26117023 missense probably damaging 1.00
IGL03194:Gm10220 APN 5 26121233 missense probably damaging 1.00
IGL03218:Gm10220 APN 5 26118698 missense probably damaging 0.99
R3014:Gm10220 UTSW 5 26117828 missense probably damaging 0.99
R3883:Gm10220 UTSW 5 26116910 missense possibly damaging 0.70
R4577:Gm10220 UTSW 5 26117871 missense probably benign
R5484:Gm10220 UTSW 5 26117932 missense possibly damaging 0.59
R6358:Gm10220 UTSW 5 26120305 intron probably null
R7951:Gm10220 UTSW 5 26118755 splice site probably null
Posted On2016-08-02