Incidental Mutation 'IGL03255:Vmo1'
ID414633
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmo1
Ensembl Gene ENSMUSG00000020830
Gene Namevitelline membrane outer layer 1 homolog (chicken)
SynonymsLOC327956
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.172) question?
Stock #IGL03255
Quality Score
Status
Chromosome11
Chromosomal Location70513516-70514616 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 70514410 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000021179 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019063] [ENSMUST00000021179] [ENSMUST00000057685]
Predicted Effect probably benign
Transcript: ENSMUST00000019063
SMART Domains Protein: ENSMUSP00000019063
Gene: ENSMUSG00000018919

DomainStartEndE-ValueType
Pfam:L6_membrane 1 189 3.8e-72 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000021179
SMART Domains Protein: ENSMUSP00000021179
Gene: ENSMUSG00000020830

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:VOMI 35 199 6.2e-64 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000057685
SMART Domains Protein: ENSMUSP00000049732
Gene: ENSMUSG00000046811

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
low complexity region 58 72 N/A INTRINSIC
Pfam:GLTP 129 283 6.6e-35 PFAM
low complexity region 286 302 N/A INTRINSIC
low complexity region 309 321 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122307
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141924
Predicted Effect noncoding transcript
Transcript: ENSMUST00000179986
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600012P17Rik A G 1: 158,969,351 noncoding transcript Het
Alpk3 A G 7: 81,092,562 D709G probably benign Het
AY761184 T C 8: 21,703,518 T29A possibly damaging Het
Capn3 G T 2: 120,489,708 R309L probably damaging Het
Card11 T C 5: 140,898,331 I398V possibly damaging Het
Cps1 T A 1: 67,145,801 Y162* probably null Het
Defa26 A T 8: 21,618,241 D20V probably damaging Het
Dnah8 T G 17: 30,741,381 L2244R probably damaging Het
Fhad1 T A 4: 141,972,880 N353I possibly damaging Het
Flt1 T A 5: 147,588,521 probably benign Het
Glyr1 G A 16: 5,048,757 probably null Het
Gm10220 A G 5: 26,116,901 S258P possibly damaging Het
Lama3 A T 18: 12,539,703 D845V probably damaging Het
Myh2 T A 11: 67,193,225 L1558Q probably damaging Het
Nelfb G T 2: 25,203,195 H482N probably benign Het
Olfr290 T C 7: 84,916,517 L246P possibly damaging Het
Olfr482 A G 7: 108,094,817 V251A probably damaging Het
Ppfia2 A G 10: 106,896,507 T972A possibly damaging Het
Slc5a4a G A 10: 76,150,512 V85M probably damaging Het
Slc6a12 T G 6: 121,354,287 C166G probably damaging Het
Tm7sf3 T C 6: 146,606,120 probably benign Het
Tmem94 G T 11: 115,792,068 probably benign Het
Tmod2 T C 9: 75,577,258 probably benign Het
Tmprss11c T A 5: 86,271,482 I73F probably damaging Het
Vmn1r10 A G 6: 57,113,926 M168V probably benign Het
Vmn2r77 T A 7: 86,811,923 M819K probably benign Het
Ywhab A G 2: 164,014,016 D104G probably benign Het
Other mutations in Vmo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Vmo1 APN 11 70513598 missense probably damaging 1.00
H8441:Vmo1 UTSW 11 70513746 missense probably damaging 1.00
PIT4791001:Vmo1 UTSW 11 70513835 missense probably damaging 1.00
R2159:Vmo1 UTSW 11 70513782 missense probably benign 0.03
R5913:Vmo1 UTSW 11 70514415 missense probably damaging 0.98
R7139:Vmo1 UTSW 11 70513848 missense probably benign 0.03
V1024:Vmo1 UTSW 11 70513746 missense probably damaging 1.00
Z1088:Vmo1 UTSW 11 70513817 missense probably damaging 1.00
Posted On2016-08-02