Incidental Mutation 'IGL03256:Olfr1474'
ID 414637
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1474
Ensembl Gene ENSMUSG00000096273
Gene Name olfactory receptor 1474
Synonyms MOR202-42, MOR202-26P, GA_x6K02T2RE5P-3803583-3804527
Accession Numbers

Genbank: NM_001011842.1
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # IGL03256
Quality Score
Status
Chromosome 19
Chromosomal Location 13469565-13472157 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13471267 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 99 (M99K)
Ref Sequence ENSEMBL: ENSMUSP00000151810 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096202] [ENSMUST00000207529] [ENSMUST00000220113]
AlphaFold Q7TQQ8
Predicted Effect probably damaging
Transcript: ENSMUST00000096202
AA Change: M99K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000093916
Gene: ENSMUSG00000096273
AA Change: M99K

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.6e-52 PFAM
Pfam:7TM_GPCR_Srsx 33 303 1e-7 PFAM
Pfam:7tm_1 39 288 8.7e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207529
AA Change: M57K

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000220113
AA Change: M99K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI

none
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik C T 8: 72,445,199 T150I probably benign Het
4932438A13Rik T C 3: 36,906,683 probably benign Het
Adam2 T C 14: 66,053,831 N333D probably benign Het
Aifm3 G A 16: 17,506,310 R578Q probably benign Het
Arid2 C A 15: 96,370,762 Q919K probably benign Het
Atp6v1a T C 16: 44,111,088 probably benign Het
Bicd1 A T 6: 149,513,585 T599S probably benign Het
Catsperg2 T A 7: 29,709,874 R601W probably damaging Het
Clca2 A C 3: 145,086,392 S369R possibly damaging Het
Cyfip1 T G 7: 55,907,434 V795G possibly damaging Het
Ddb1 A G 19: 10,621,861 T544A probably benign Het
Defb43 T C 14: 63,017,880 I54T probably damaging Het
Dera A G 6: 137,779,645 M89V probably benign Het
Fam227b T A 2: 125,989,003 K427I probably damaging Het
Frk A G 10: 34,607,842 I400V probably benign Het
Gk5 T A 9: 96,129,053 L72H probably damaging Het
Gprc6a T A 10: 51,628,349 Y133F possibly damaging Het
Hecw1 G T 13: 14,280,485 L662M probably benign Het
Hecw1 A G 13: 14,280,484 L662P probably damaging Het
Il12b T A 11: 44,407,930 S71T probably benign Het
Kdm2a A T 19: 4,345,510 probably benign Het
Lhfp A G 3: 53,043,553 R83G possibly damaging Het
Magel2 C A 7: 62,380,414 T1022K unknown Het
Mycbp2 C A 14: 103,188,589 V2367F possibly damaging Het
Nap1l3 C T X: 122,396,208 G271D probably benign Het
Nars2 T A 7: 97,039,910 D346E possibly damaging Het
Nek11 T A 9: 105,244,414 E435D probably damaging Het
Nfam1 C T 15: 83,010,410 G205R probably benign Het
Olfr395 A T 11: 73,906,696 N265K probably benign Het
Olfr433 T C 1: 174,042,208 L86P probably damaging Het
Otud3 G A 4: 138,909,617 R78W probably damaging Het
Oxct2a C T 4: 123,322,965 A208T probably damaging Het
Pcdh11x A T X: 120,400,910 E683D probably benign Het
Phtf2 C A 5: 20,803,252 V144L probably damaging Het
Pkn2 T C 3: 142,803,550 probably null Het
Puf60 T A 15: 76,070,596 D459V possibly damaging Het
Ralgapa2 A G 2: 146,460,712 probably null Het
Rapgef6 A C 11: 54,657,429 Q813P probably damaging Het
Rsf1 A T 7: 97,679,004 D1071V possibly damaging Het
Sctr T C 1: 120,031,559 probably benign Het
Serpini1 A G 3: 75,619,174 I244M probably benign Het
Tada2a C A 11: 84,087,192 probably benign Het
Tada3 A T 6: 113,375,131 H112Q possibly damaging Het
Tnxb T A 17: 34,688,720 L1246Q probably damaging Het
Txndc16 T C 14: 45,151,896 N449S probably damaging Het
Usp34 T A 11: 23,420,090 Y1771* probably null Het
Vav2 A T 2: 27,271,900 probably null Het
Virma T C 4: 11,542,207 probably benign Het
Vmn1r78 T A 7: 12,152,798 I112N probably damaging Het
Vnn3 A T 10: 23,851,800 probably benign Het
Other mutations in Olfr1474
AlleleSourceChrCoordTypePredicted EffectPPH Score
D605:Olfr1474 UTSW 19 13471157 nonsense probably null
R0173:Olfr1474 UTSW 19 13471701 missense probably benign 0.02
R1102:Olfr1474 UTSW 19 13471407 missense probably damaging 0.97
R1515:Olfr1474 UTSW 19 13471680 missense probably damaging 0.97
R1780:Olfr1474 UTSW 19 13471362 missense probably benign 0.14
R2061:Olfr1474 UTSW 19 13471241 missense probably damaging 0.98
R4016:Olfr1474 UTSW 19 13471197 missense possibly damaging 0.95
R4485:Olfr1474 UTSW 19 13471555 missense probably benign 0.08
R5119:Olfr1474 UTSW 19 13471546 missense probably benign 0.00
R5150:Olfr1474 UTSW 19 13471430 missense probably benign 0.01
R5156:Olfr1474 UTSW 19 13471673 missense probably damaging 1.00
R5699:Olfr1474 UTSW 19 13470972 start codon destroyed probably null 0.78
R5800:Olfr1474 UTSW 19 13471896 missense probably benign 0.06
R5840:Olfr1474 UTSW 19 13471878 missense probably benign 0.01
R5953:Olfr1474 UTSW 19 13471368 missense possibly damaging 0.92
R5997:Olfr1474 UTSW 19 13471506 missense probably benign 0.12
R6233:Olfr1474 UTSW 19 13471740 missense probably damaging 1.00
R6488:Olfr1474 UTSW 19 13471617 missense probably damaging 1.00
R6847:Olfr1474 UTSW 19 13471038 missense probably benign 0.03
R6964:Olfr1474 UTSW 19 13471361 nonsense probably null
R7214:Olfr1474 UTSW 19 13470973 start codon destroyed probably null 1.00
R8001:Olfr1474 UTSW 19 13471422 missense probably benign 0.03
R8035:Olfr1474 UTSW 19 13471899 missense probably benign
R8129:Olfr1474 UTSW 19 13471144 missense probably damaging 1.00
R9018:Olfr1474 UTSW 19 13471357 missense possibly damaging 0.60
R9061:Olfr1474 UTSW 19 13471159 missense probably damaging 0.98
R9065:Olfr1474 UTSW 19 13471306 missense probably damaging 0.97
R9373:Olfr1474 UTSW 19 13471852 missense probably damaging 1.00
Posted On 2016-08-02