Incidental Mutation 'IGL03256:Or5b118'
ID 414637
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5b118
Ensembl Gene ENSMUSG00000096273
Gene Name olfactory receptor family 5 subfamily B member 118
Synonyms Olfr1474, MOR202-26P, GA_x6K02T2RE5P-3803583-3804527, MOR202-42
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # IGL03256
Quality Score
Status
Chromosome 19
Chromosomal Location 13448336-13449280 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13448631 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 99 (M99K)
Ref Sequence ENSEMBL: ENSMUSP00000151810 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096202] [ENSMUST00000207529] [ENSMUST00000220113]
AlphaFold Q7TQQ8
Predicted Effect probably damaging
Transcript: ENSMUST00000096202
AA Change: M99K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000093916
Gene: ENSMUSG00000096273
AA Change: M99K

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.6e-52 PFAM
Pfam:7TM_GPCR_Srsx 33 303 1e-7 PFAM
Pfam:7tm_1 39 288 8.7e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207529
AA Change: M57K

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000220113
AA Change: M99K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI

none

Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik C T 8: 73,199,043 (GRCm39) T150I probably benign Het
Adam2 T C 14: 66,291,280 (GRCm39) N333D probably benign Het
Aifm3 G A 16: 17,324,174 (GRCm39) R578Q probably benign Het
Arid2 C A 15: 96,268,643 (GRCm39) Q919K probably benign Het
Atp6v1a T C 16: 43,931,451 (GRCm39) probably benign Het
Bicd1 A T 6: 149,415,083 (GRCm39) T599S probably benign Het
Bltp1 T C 3: 36,960,832 (GRCm39) probably benign Het
Catsperg2 T A 7: 29,409,299 (GRCm39) R601W probably damaging Het
Clca3a2 A C 3: 144,792,153 (GRCm39) S369R possibly damaging Het
Cyfip1 T G 7: 55,557,182 (GRCm39) V795G possibly damaging Het
Ddb1 A G 19: 10,599,225 (GRCm39) T544A probably benign Het
Defb43 T C 14: 63,255,329 (GRCm39) I54T probably damaging Het
Dera A G 6: 137,756,643 (GRCm39) M89V probably benign Het
Fam227b T A 2: 125,830,923 (GRCm39) K427I probably damaging Het
Frk A G 10: 34,483,838 (GRCm39) I400V probably benign Het
Gk5 T A 9: 96,011,106 (GRCm39) L72H probably damaging Het
Gprc6a T A 10: 51,504,445 (GRCm39) Y133F possibly damaging Het
Hecw1 A G 13: 14,455,069 (GRCm39) L662P probably damaging Het
Hecw1 G T 13: 14,455,070 (GRCm39) L662M probably benign Het
Il12b T A 11: 44,298,757 (GRCm39) S71T probably benign Het
Kdm2a A T 19: 4,395,538 (GRCm39) probably benign Het
Lhfpl6 A G 3: 52,950,974 (GRCm39) R83G possibly damaging Het
Magel2 C A 7: 62,030,162 (GRCm39) T1022K unknown Het
Mycbp2 C A 14: 103,426,025 (GRCm39) V2367F possibly damaging Het
Nap1l3 C T X: 121,305,905 (GRCm39) G271D probably benign Het
Nars2 T A 7: 96,689,117 (GRCm39) D346E possibly damaging Het
Nek11 T A 9: 105,121,613 (GRCm39) E435D probably damaging Het
Nfam1 C T 15: 82,894,611 (GRCm39) G205R probably benign Het
Or10aa1 T C 1: 173,869,774 (GRCm39) L86P probably damaging Het
Or1e35 A T 11: 73,797,522 (GRCm39) N265K probably benign Het
Otud3 G A 4: 138,636,928 (GRCm39) R78W probably damaging Het
Oxct2a C T 4: 123,216,758 (GRCm39) A208T probably damaging Het
Pcdh11x A T X: 119,310,607 (GRCm39) E683D probably benign Het
Phtf2 C A 5: 21,008,250 (GRCm39) V144L probably damaging Het
Pkn2 T C 3: 142,509,311 (GRCm39) probably null Het
Puf60 T A 15: 75,942,445 (GRCm39) D459V possibly damaging Het
Ralgapa2 A G 2: 146,302,632 (GRCm39) probably null Het
Rapgef6 A C 11: 54,548,255 (GRCm39) Q813P probably damaging Het
Rsf1 A T 7: 97,328,211 (GRCm39) D1071V possibly damaging Het
Sctr T C 1: 119,959,289 (GRCm39) probably benign Het
Serpini1 A G 3: 75,526,481 (GRCm39) I244M probably benign Het
Tada2a C A 11: 83,978,018 (GRCm39) probably benign Het
Tada3 A T 6: 113,352,092 (GRCm39) H112Q possibly damaging Het
Tnxb T A 17: 34,907,694 (GRCm39) L1246Q probably damaging Het
Txndc16 T C 14: 45,389,353 (GRCm39) N449S probably damaging Het
Usp34 T A 11: 23,370,090 (GRCm39) Y1771* probably null Het
Vav2 A T 2: 27,161,912 (GRCm39) probably null Het
Virma T C 4: 11,542,207 (GRCm39) probably benign Het
Vmn1r78 T A 7: 11,886,725 (GRCm39) I112N probably damaging Het
Vnn3 A T 10: 23,727,698 (GRCm39) probably benign Het
Other mutations in Or5b118
AlleleSourceChrCoordTypePredicted EffectPPH Score
D605:Or5b118 UTSW 19 13,448,521 (GRCm39) nonsense probably null
R0173:Or5b118 UTSW 19 13,449,065 (GRCm39) missense probably benign 0.02
R1102:Or5b118 UTSW 19 13,448,771 (GRCm39) missense probably damaging 0.97
R1515:Or5b118 UTSW 19 13,449,044 (GRCm39) missense probably damaging 0.97
R1780:Or5b118 UTSW 19 13,448,726 (GRCm39) missense probably benign 0.14
R2061:Or5b118 UTSW 19 13,448,605 (GRCm39) missense probably damaging 0.98
R4016:Or5b118 UTSW 19 13,448,561 (GRCm39) missense possibly damaging 0.95
R4485:Or5b118 UTSW 19 13,448,919 (GRCm39) missense probably benign 0.08
R5119:Or5b118 UTSW 19 13,448,910 (GRCm39) missense probably benign 0.00
R5150:Or5b118 UTSW 19 13,448,794 (GRCm39) missense probably benign 0.01
R5156:Or5b118 UTSW 19 13,449,037 (GRCm39) missense probably damaging 1.00
R5699:Or5b118 UTSW 19 13,448,336 (GRCm39) start codon destroyed probably null 0.78
R5800:Or5b118 UTSW 19 13,449,260 (GRCm39) missense probably benign 0.06
R5840:Or5b118 UTSW 19 13,449,242 (GRCm39) missense probably benign 0.01
R5953:Or5b118 UTSW 19 13,448,732 (GRCm39) missense possibly damaging 0.92
R5997:Or5b118 UTSW 19 13,448,870 (GRCm39) missense probably benign 0.12
R6233:Or5b118 UTSW 19 13,449,104 (GRCm39) missense probably damaging 1.00
R6488:Or5b118 UTSW 19 13,448,981 (GRCm39) missense probably damaging 1.00
R6847:Or5b118 UTSW 19 13,448,402 (GRCm39) missense probably benign 0.03
R6964:Or5b118 UTSW 19 13,448,725 (GRCm39) nonsense probably null
R7214:Or5b118 UTSW 19 13,448,337 (GRCm39) start codon destroyed probably null 1.00
R8001:Or5b118 UTSW 19 13,448,786 (GRCm39) missense probably benign 0.03
R8035:Or5b118 UTSW 19 13,449,263 (GRCm39) missense probably benign
R8129:Or5b118 UTSW 19 13,448,508 (GRCm39) missense probably damaging 1.00
R9018:Or5b118 UTSW 19 13,448,721 (GRCm39) missense possibly damaging 0.60
R9061:Or5b118 UTSW 19 13,448,523 (GRCm39) missense probably damaging 0.98
R9065:Or5b118 UTSW 19 13,448,670 (GRCm39) missense probably damaging 0.97
R9373:Or5b118 UTSW 19 13,449,216 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02