Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03256:Dera'

414655

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dera

Ensembl Gene

ENSMUSG00000030225

Gene Name

deoxyribose-phosphate aldolase (putative)

Synonyms

2010002D22Rik, 2500002K03Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03256

Quality Score

Status

Chromosome

Chromosomal Location

137754546-137857340 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 137779645 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 89 (M89V)

Ref Sequence

ENSEMBL: ENSMUSP00000144935 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087675] [ENSMUST00000203216] [ENSMUST00000203693]

AlphaFold

Q91YP3

Predicted Effect

probably benign
Transcript: ENSMUST00000087675
AA Change: M89V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000084959
Gene: ENSMUSG00000030225
AA Change: M89V

Domain	Start	End	E-Value	Type
DeoC	49	299	1.16e-79	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203046

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203136

Predicted Effect

probably benign
Transcript: ENSMUST00000203216

SMART Domains

Protein: ENSMUSP00000145264
Gene: ENSMUSG00000030225

Domain	Start	End	E-Value	Type
Pfam:DeoC	2	97	1e-6	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203693
AA Change: M89V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000144935
Gene: ENSMUSG00000030225
AA Change: M89V

Domain	Start	End	E-Value	Type
DeoC	49	271	4.4e-50	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203754

Predicted Effect

probably benign
Transcript: ENSMUST00000204356

Predicted Effect

probably benign
Transcript: ENSMUST00000204779

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700030K09Rik	C	T	8: 72,445,199	T150I	probably benign	Het
4932438A13Rik	T	C	3: 36,906,683		probably benign	Het
Adam2	T	C	14: 66,053,831	N333D	probably benign	Het
Aifm3	G	A	16: 17,506,310	R578Q	probably benign	Het
Arid2	C	A	15: 96,370,762	Q919K	probably benign	Het
Atp6v1a	T	C	16: 44,111,088		probably benign	Het
Bicd1	A	T	6: 149,513,585	T599S	probably benign	Het
Catsperg2	T	A	7: 29,709,874	R601W	probably damaging	Het
Clca2	A	C	3: 145,086,392	S369R	possibly damaging	Het
Cyfip1	T	G	7: 55,907,434	V795G	possibly damaging	Het
Ddb1	A	G	19: 10,621,861	T544A	probably benign	Het
Defb43	T	C	14: 63,017,880	I54T	probably damaging	Het
Fam227b	T	A	2: 125,989,003	K427I	probably damaging	Het
Frk	A	G	10: 34,607,842	I400V	probably benign	Het
Gk5	T	A	9: 96,129,053	L72H	probably damaging	Het
Gprc6a	T	A	10: 51,628,349	Y133F	possibly damaging	Het
Hecw1	A	G	13: 14,280,484	L662P	probably damaging	Het
Hecw1	G	T	13: 14,280,485	L662M	probably benign	Het
Il12b	T	A	11: 44,407,930	S71T	probably benign	Het
Kdm2a	A	T	19: 4,345,510		probably benign	Het
Lhfp	A	G	3: 53,043,553	R83G	possibly damaging	Het
Magel2	C	A	7: 62,380,414	T1022K	unknown	Het
Mycbp2	C	A	14: 103,188,589	V2367F	possibly damaging	Het
Nap1l3	C	T	X: 122,396,208	G271D	probably benign	Het
Nars2	T	A	7: 97,039,910	D346E	possibly damaging	Het
Nek11	T	A	9: 105,244,414	E435D	probably damaging	Het
Nfam1	C	T	15: 83,010,410	G205R	probably benign	Het
Olfr1474	T	A	19: 13,471,267	M99K	probably damaging	Het
Olfr395	A	T	11: 73,906,696	N265K	probably benign	Het
Olfr433	T	C	1: 174,042,208	L86P	probably damaging	Het
Otud3	G	A	4: 138,909,617	R78W	probably damaging	Het
Oxct2a	C	T	4: 123,322,965	A208T	probably damaging	Het
Pcdh11x	A	T	X: 120,400,910	E683D	probably benign	Het
Phtf2	C	A	5: 20,803,252	V144L	probably damaging	Het
Pkn2	T	C	3: 142,803,550		probably null	Het
Puf60	T	A	15: 76,070,596	D459V	possibly damaging	Het
Ralgapa2	A	G	2: 146,460,712		probably null	Het
Rapgef6	A	C	11: 54,657,429	Q813P	probably damaging	Het
Rsf1	A	T	7: 97,679,004	D1071V	possibly damaging	Het
Sctr	T	C	1: 120,031,559		probably benign	Het
Serpini1	A	G	3: 75,619,174	I244M	probably benign	Het
Tada2a	C	A	11: 84,087,192		probably benign	Het
Tada3	A	T	6: 113,375,131	H112Q	possibly damaging	Het
Tnxb	T	A	17: 34,688,720	L1246Q	probably damaging	Het
Txndc16	T	C	14: 45,151,896	N449S	probably damaging	Het
Usp34	T	A	11: 23,420,090	Y1771*	probably null	Het
Vav2	A	T	2: 27,271,900		probably null	Het
Virma	T	C	4: 11,542,207		probably benign	Het
Vmn1r78	T	A	7: 12,152,798	I112N	probably damaging	Het
Vnn3	A	T	10: 23,851,800		probably benign	Het

Other mutations in Dera

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02134:Dera	APN	6	137830271	missense	probably damaging	1.00
IGL02220:Dera	APN	6	137780817	splice site	probably null
IGL02449:Dera	APN	6	137780817	splice site	probably null
R0644:Dera	UTSW	6	137783048	missense	probably benign	0.10
R0691:Dera	UTSW	6	137796747	intron	probably benign
R0733:Dera	UTSW	6	137796848	missense	probably damaging	1.00
R1478:Dera	UTSW	6	137830195	missense	possibly damaging	0.91
R3950:Dera	UTSW	6	137837120	missense	probably damaging	0.99
R3951:Dera	UTSW	6	137837120	missense	probably damaging	0.99
R3952:Dera	UTSW	6	137837120	missense	probably damaging	0.99
R4561:Dera	UTSW	6	137780738	missense	possibly damaging	0.83
R7687:Dera	UTSW	6	137836880	missense
R7956:Dera	UTSW	6	137836828	missense	probably benign	0.02
R8676:Dera	UTSW	6	137830204	missense	probably damaging	1.00
R9600:Dera	UTSW	6	137837137	missense	probably benign	0.04
R9607:Dera	UTSW	6	137856734	missense	unknown
R9608:Dera	UTSW	6	137836878	missense	possibly damaging	0.81
Z1088:Dera	UTSW	6	137837118	missense	possibly damaging	0.87

Posted On

2016-08-02