Incidental Mutation 'IGL03256:Otud3'
ID414673
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Otud3
Ensembl Gene ENSMUSG00000041161
Gene NameOTU domain containing 3
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03256
Quality Score
Status
Chromosome4
Chromosomal Location138895379-138913945 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 138909617 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Tryptophan at position 78 (R78W)
Ref Sequence ENSEMBL: ENSMUSP00000095441 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097830]
Predicted Effect probably damaging
Transcript: ENSMUST00000097830
AA Change: R78W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000095441
Gene: ENSMUSG00000041161
AA Change: R78W

DomainStartEndE-ValueType
low complexity region 16 40 N/A INTRINSIC
Pfam:OTU 70 185 3.6e-12 PFAM
coiled coil region 340 370 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik C T 8: 72,445,199 T150I probably benign Het
4932438A13Rik T C 3: 36,906,683 probably benign Het
Adam2 T C 14: 66,053,831 N333D probably benign Het
Aifm3 G A 16: 17,506,310 R578Q probably benign Het
Arid2 C A 15: 96,370,762 Q919K probably benign Het
Atp6v1a T C 16: 44,111,088 probably benign Het
Bicd1 A T 6: 149,513,585 T599S probably benign Het
Catsperg2 T A 7: 29,709,874 R601W probably damaging Het
Clca2 A C 3: 145,086,392 S369R possibly damaging Het
Cyfip1 T G 7: 55,907,434 V795G possibly damaging Het
Ddb1 A G 19: 10,621,861 T544A probably benign Het
Defb43 T C 14: 63,017,880 I54T probably damaging Het
Dera A G 6: 137,779,645 M89V probably benign Het
Fam227b T A 2: 125,989,003 K427I probably damaging Het
Frk A G 10: 34,607,842 I400V probably benign Het
Gk5 T A 9: 96,129,053 L72H probably damaging Het
Gprc6a T A 10: 51,628,349 Y133F possibly damaging Het
Hecw1 A G 13: 14,280,484 L662P probably damaging Het
Hecw1 G T 13: 14,280,485 L662M probably benign Het
Il12b T A 11: 44,407,930 S71T probably benign Het
Kdm2a A T 19: 4,345,510 probably benign Het
Lhfp A G 3: 53,043,553 R83G possibly damaging Het
Magel2 C A 7: 62,380,414 T1022K unknown Het
Mycbp2 C A 14: 103,188,589 V2367F possibly damaging Het
Nap1l3 C T X: 122,396,208 G271D probably benign Het
Nars2 T A 7: 97,039,910 D346E possibly damaging Het
Nek11 T A 9: 105,244,414 E435D probably damaging Het
Nfam1 C T 15: 83,010,410 G205R probably benign Het
Olfr1474 T A 19: 13,471,267 M99K probably damaging Het
Olfr395 A T 11: 73,906,696 N265K probably benign Het
Olfr433 T C 1: 174,042,208 L86P probably damaging Het
Oxct2a C T 4: 123,322,965 A208T probably damaging Het
Pcdh11x A T X: 120,400,910 E683D probably benign Het
Phtf2 C A 5: 20,803,252 V144L probably damaging Het
Pkn2 T C 3: 142,803,550 probably null Het
Puf60 T A 15: 76,070,596 D459V possibly damaging Het
Ralgapa2 A G 2: 146,460,712 probably null Het
Rapgef6 A C 11: 54,657,429 Q813P probably damaging Het
Rsf1 A T 7: 97,679,004 D1071V possibly damaging Het
Sctr T C 1: 120,031,559 probably benign Het
Serpini1 A G 3: 75,619,174 I244M probably benign Het
Tada2a C A 11: 84,087,192 probably benign Het
Tada3 A T 6: 113,375,131 H112Q possibly damaging Het
Tnxb T A 17: 34,688,720 L1246Q probably damaging Het
Txndc16 T C 14: 45,151,896 N449S probably damaging Het
Usp34 T A 11: 23,420,090 Y1771* probably null Het
Vav2 A T 2: 27,271,900 probably null Het
Virma T C 4: 11,542,207 probably benign Het
Vmn1r78 T A 7: 12,152,798 I112N probably damaging Het
Vnn3 A T 10: 23,851,800 probably benign Het
Other mutations in Otud3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01785:Otud3 APN 4 138896897 missense probably benign
IGL01786:Otud3 APN 4 138896897 missense probably benign
IGL02125:Otud3 APN 4 138896714 critical splice donor site probably null
R0647:Otud3 UTSW 4 138913637 missense probably damaging 1.00
R1723:Otud3 UTSW 4 138898018 missense probably damaging 0.99
R1744:Otud3 UTSW 4 138895748 missense probably damaging 1.00
R1760:Otud3 UTSW 4 138895781 missense possibly damaging 0.51
R1954:Otud3 UTSW 4 138898032 missense possibly damaging 0.86
R3900:Otud3 UTSW 4 138896885 missense probably benign
R4890:Otud3 UTSW 4 138913749 missense probably damaging 1.00
R5534:Otud3 UTSW 4 138897583 missense probably damaging 1.00
R5769:Otud3 UTSW 4 138898110 missense possibly damaging 0.89
R5948:Otud3 UTSW 4 138897614 missense probably benign 0.00
R6235:Otud3 UTSW 4 138901901 missense probably damaging 1.00
R7121:Otud3 UTSW 4 138896756 missense probably benign 0.01
R7189:Otud3 UTSW 4 138909554 missense probably damaging 1.00
R7555:Otud3 UTSW 4 138901885 missense possibly damaging 0.77
R8034:Otud3 UTSW 4 138895800 missense probably benign 0.01
Z1177:Otud3 UTSW 4 138896775 missense possibly damaging 0.87
Posted On2016-08-02