Incidental Mutation 'IGL03257:Olfr1065'
ID414689
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1065
Ensembl Gene ENSMUSG00000111306
Gene Nameolfactory receptor 1065
SynonymsMOR190-1, GA_x6K02T2Q125-47915274-47914333
Accession Numbers

Genbank: NM_146408; MGI: 3030899

Is this an essential gene? Probably non essential (E-score: 0.216) question?
Stock #IGL03257
Quality Score
Status
Chromosome2
Chromosomal Location86443958-86450591 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 86445890 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 31 (F31I)
Ref Sequence ENSEMBL: ENSMUSP00000149248 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000213789] [ENSMUST00000216162] [ENSMUST00000216165] [ENSMUST00000217586]
Predicted Effect probably damaging
Transcript: ENSMUST00000099886
AA Change: F31I

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000097471
Gene: ENSMUSG00000075182
AA Change: F31I

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.1e-53 PFAM
Pfam:7tm_1 41 290 1.2e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213789
AA Change: F31I

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000216162
AA Change: F31I

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000216165
AA Change: F31I

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000217586
AA Change: F31I

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 C A 14: 118,615,211 V489L probably benign Het
Alpk2 C A 18: 65,349,874 E354D probably damaging Het
Ank1 A T 8: 23,122,898 K1060M probably damaging Het
Cand2 A G 6: 115,799,983 N1111D possibly damaging Het
Ccny A T 18: 9,386,747 S73T possibly damaging Het
Clps T C 17: 28,560,660 probably benign Het
Cnga1 C A 5: 72,610,862 W160C probably damaging Het
Col6a5 T C 9: 105,881,873 S2045G possibly damaging Het
Dennd4a T G 9: 64,871,874 N546K possibly damaging Het
Efcab5 A T 11: 77,188,770 M50K probably damaging Het
Fntb A G 12: 76,888,031 H228R probably damaging Het
Gm4787 C T 12: 81,378,052 C444Y probably damaging Het
Gpm6a A G 8: 55,037,472 Y61C probably damaging Het
Grm5 T A 7: 87,602,898 S119T possibly damaging Het
Igf1r T A 7: 68,214,940 I1162N probably damaging Het
Irx5 A G 8: 92,360,630 T397A probably benign Het
Kdm1b C T 13: 47,049,266 T59M probably damaging Het
Lrrc9 T A 12: 72,449,768 S57T probably benign Het
Nup210l A T 3: 90,180,148 probably null Het
Olfr472 T C 7: 107,902,756 I13T probably benign Het
Prl8a1 A G 13: 27,575,673 I127T probably damaging Het
Psme1 T C 14: 55,580,629 I142T probably damaging Het
Ptbp3 A T 4: 59,493,370 probably benign Het
Rnf20 T A 4: 49,645,687 N321K probably benign Het
Ttc23 T C 7: 67,711,378 S340P probably damaging Het
Txnrd1 A T 10: 82,885,271 K393I probably benign Het
Zfp365 A T 10: 67,889,038 F340Y possibly damaging Het
Zfp451 C A 1: 33,777,048 R607L possibly damaging Het
Zfp618 A G 4: 63,132,671 Y563C probably damaging Het
Other mutations in Olfr1065
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03133:Olfr1065 APN 2 86445658 missense probably damaging 0.99
IGL03173:Olfr1065 APN 2 86445444 nonsense probably null
D4043:Olfr1065 UTSW 2 86445220 missense probably damaging 0.99
R0265:Olfr1065 UTSW 2 86445959 missense probably benign 0.00
R0550:Olfr1065 UTSW 2 86445876 nonsense probably null
R0633:Olfr1065 UTSW 2 86445129 missense probably benign 0.45
R0727:Olfr1065 UTSW 2 86445938 missense probably benign 0.00
R1017:Olfr1065 UTSW 2 86445428 missense probably benign 0.13
R1416:Olfr1065 UTSW 2 86445320 missense probably benign 0.43
R1657:Olfr1065 UTSW 2 86445218 missense probably damaging 1.00
R1983:Olfr1065 UTSW 2 86445076 missense probably benign 0.01
R3919:Olfr1065 UTSW 2 86445418 missense probably benign 0.01
R4345:Olfr1065 UTSW 2 86445845 missense probably damaging 1.00
R5382:Olfr1065 UTSW 2 86445316 missense probably damaging 0.99
R5757:Olfr1065 UTSW 2 86445578 missense probably benign 0.22
R6530:Olfr1065 UTSW 2 86445482 missense probably benign 0.31
R6765:Olfr1065 UTSW 2 86445236 missense probably benign 0.04
R6856:Olfr1065 UTSW 2 86445907 missense probably benign 0.04
R7156:Olfr1065 UTSW 2 86445308 missense probably damaging 1.00
R8239:Olfr1065 UTSW 2 86445129 missense noncoding transcript
R8338:Olfr1065 UTSW 2 86445385 missense probably benign 0.00
Posted On2016-08-02