Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03260:Vmn2r104'

414773

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r104

Ensembl Gene

ENSMUSG00000090315

Gene Name

vomeronasal 2, receptor 104

Synonyms

V2r7

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

IGL03260

Quality Score

Status

Chromosome

Chromosomal Location

20029425-20048205 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 20042821 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 126 (C126Y)

Ref Sequence

ENSEMBL: ENSMUSP00000129895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168050]

AlphaFold

E9Q2J5

Predicted Effect

probably benign
Transcript: ENSMUST00000168050
AA Change: C126Y

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: C126Y

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	85	457	4e-38	PFAM
Pfam:NCD3G	512	565	2.1e-20	PFAM
Pfam:7tm_3	598	833	1.7e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933406P04Rik	A	G	10: 20,311,325 (GRCm38)		probably benign	Het
Abca12	A	G	1: 71,284,099 (GRCm38)	L1608P	probably damaging	Het
Akr1b8	G	T	6: 34,363,459 (GRCm38)		probably benign	Het
Appbp2	A	G	11: 85,216,457 (GRCm38)	V69A	probably benign	Het
Ces1e	T	C	8: 93,223,917 (GRCm38)	N79D	probably benign	Het
Cldn34b3	A	G	X: 76,266,873 (GRCm38)	T16A	probably damaging	Het
Frmd4b	A	T	6: 97,396,224 (GRCm38)	F103Y	probably damaging	Het
Ifi47	T	C	11: 49,096,105 (GRCm38)	F233S	probably damaging	Het
Igkv8-30	A	T	6: 70,117,355 (GRCm38)	M24K	probably damaging	Het
Krt72	C	T	15: 101,778,273 (GRCm38)	A413T	probably damaging	Het
Lingo4	A	G	3: 94,401,943 (GRCm38)	T63A	probably benign	Het
Naa35	T	G	13: 59,627,885 (GRCm38)	S125A	probably benign	Het
Olfr5	A	T	7: 6,480,659 (GRCm38)	C166S	probably damaging	Het
Olfr809	T	C	10: 129,776,652 (GRCm38)	V261A	probably damaging	Het
Padi1	T	C	4: 140,828,194 (GRCm38)	H240R	probably benign	Het
Ppp1r12a	A	G	10: 108,261,245 (GRCm38)	T240A	probably benign	Het
Ppp2ca	A	G	11: 52,113,148 (GRCm38)	N44S	probably damaging	Het
Prg4	T	A	1: 150,455,627 (GRCm38)		probably benign	Het
Rab33a	A	G	X: 48,519,668 (GRCm38)	E23G	probably benign	Het
Scarb2	G	T	5: 92,446,437 (GRCm38)	A422E	probably damaging	Het
Scn4b	A	T	9: 45,147,689 (GRCm38)	N86I	probably damaging	Het
Serpina1d	G	A	12: 103,763,849 (GRCm38)	T358I	probably damaging	Het
Slc12a3	T	A	8: 94,333,242 (GRCm38)	I172N	probably damaging	Het
Slc18a1	T	C	8: 69,075,114 (GRCm38)	E15G	probably benign	Het
Snx7	A	G	3: 117,782,293 (GRCm38)		probably benign	Het
Srpx	T	A	X: 10,055,748 (GRCm38)	K216*	probably null	Het
Ugt2a3	G	A	5: 87,336,580 (GRCm38)	P195L	probably damaging	Het
Unc13c	A	G	9: 73,931,344 (GRCm38)	S742P	probably benign	Het
Vmn2r63	A	T	7: 42,929,192 (GRCm38)	N92K	probably damaging	Het

Other mutations in Vmn2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn2r104	APN	17	20,038,239 (GRCm38)	missense	probably damaging	0.98
IGL01098:Vmn2r104	APN	17	20,048,096 (GRCm38)	missense	probably benign	0.27
IGL01333:Vmn2r104	APN	17	20,042,793 (GRCm38)	missense	probably benign	0.17
IGL01527:Vmn2r104	APN	17	20,042,896 (GRCm38)	missense	possibly damaging	0.82
IGL01773:Vmn2r104	APN	17	20,040,668 (GRCm38)	missense	probably benign	0.10
IGL01939:Vmn2r104	APN	17	20,029,925 (GRCm38)	missense	probably damaging	0.99
IGL02121:Vmn2r104	APN	17	20,041,794 (GRCm38)	nonsense	probably null
IGL02305:Vmn2r104	APN	17	20,042,856 (GRCm38)	missense	probably benign	0.09
IGL02374:Vmn2r104	APN	17	20,042,786 (GRCm38)	missense	probably benign	0.34
IGL03366:Vmn2r104	APN	17	20,029,604 (GRCm38)	missense	probably damaging	1.00
R0091:Vmn2r104	UTSW	17	20,041,813 (GRCm38)	missense	possibly damaging	0.79
R0125:Vmn2r104	UTSW	17	20,029,807 (GRCm38)	missense	probably damaging	0.98
R0257:Vmn2r104	UTSW	17	20,029,627 (GRCm38)	missense	probably damaging	1.00
R0381:Vmn2r104	UTSW	17	20,048,002 (GRCm38)	nonsense	probably null
R0709:Vmn2r104	UTSW	17	20,042,904 (GRCm38)	missense	probably damaging	1.00
R0786:Vmn2r104	UTSW	17	20,042,725 (GRCm38)	missense	probably benign
R1575:Vmn2r104	UTSW	17	20,042,215 (GRCm38)	missense	probably damaging	1.00
R1827:Vmn2r104	UTSW	17	20,042,235 (GRCm38)	missense	probably damaging	0.97
R1932:Vmn2r104	UTSW	17	20,040,769 (GRCm38)	missense	probably damaging	1.00
R1956:Vmn2r104	UTSW	17	20,042,051 (GRCm38)	missense	probably damaging	0.98
R2203:Vmn2r104	UTSW	17	20,029,821 (GRCm38)	missense	probably benign	0.05
R2205:Vmn2r104	UTSW	17	20,029,821 (GRCm38)	missense	probably benign	0.05
R2859:Vmn2r104	UTSW	17	20,048,193 (GRCm38)	missense	possibly damaging	0.82
R3701:Vmn2r104	UTSW	17	20,029,556 (GRCm38)	missense	probably damaging	1.00
R3834:Vmn2r104	UTSW	17	20,029,921 (GRCm38)	missense	probably benign	0.02
R4151:Vmn2r104	UTSW	17	20,029,885 (GRCm38)	missense	probably damaging	1.00
R4470:Vmn2r104	UTSW	17	20,042,241 (GRCm38)	missense	probably damaging	1.00
R4625:Vmn2r104	UTSW	17	20,048,181 (GRCm38)	missense	probably benign	0.00
R4754:Vmn2r104	UTSW	17	20,040,768 (GRCm38)	nonsense	probably null
R4911:Vmn2r104	UTSW	17	20,030,026 (GRCm38)	missense	probably benign	0.00
R5270:Vmn2r104	UTSW	17	20,038,266 (GRCm38)	missense	probably damaging	1.00
R5279:Vmn2r104	UTSW	17	20,041,884 (GRCm38)	missense	probably benign	0.07
R5311:Vmn2r104	UTSW	17	20,029,901 (GRCm38)	missense	probably damaging	1.00
R5370:Vmn2r104	UTSW	17	20,030,188 (GRCm38)	missense	probably damaging	0.97
R5461:Vmn2r104	UTSW	17	20,030,081 (GRCm38)	missense	probably damaging	1.00
R5683:Vmn2r104	UTSW	17	20,040,719 (GRCm38)	nonsense	probably null
R5795:Vmn2r104	UTSW	17	20,030,110 (GRCm38)	missense	probably benign	0.02
R5795:Vmn2r104	UTSW	17	20,030,282 (GRCm38)	missense	possibly damaging	0.89
R5970:Vmn2r104	UTSW	17	20,029,471 (GRCm38)	missense	probably benign	0.01
R5983:Vmn2r104	UTSW	17	20,041,708 (GRCm38)	missense	probably damaging	1.00
R5992:Vmn2r104	UTSW	17	20,029,485 (GRCm38)	missense	probably damaging	1.00
R6066:Vmn2r104	UTSW	17	20,038,311 (GRCm38)	missense	possibly damaging	0.69
R6156:Vmn2r104	UTSW	17	20,041,647 (GRCm38)	missense	probably damaging	1.00
R6182:Vmn2r104	UTSW	17	20,030,245 (GRCm38)	missense	probably benign	0.16
R6245:Vmn2r104	UTSW	17	20,041,567 (GRCm38)	missense	possibly damaging	0.69
R6333:Vmn2r104	UTSW	17	20,029,586 (GRCm38)	missense	probably benign	0.30
R6573:Vmn2r104	UTSW	17	20,042,225 (GRCm38)	missense	probably damaging	1.00
R7101:Vmn2r104	UTSW	17	20,030,096 (GRCm38)	missense	possibly damaging	0.65
R7123:Vmn2r104	UTSW	17	20,040,826 (GRCm38)	missense	probably benign	0.12
R7485:Vmn2r104	UTSW	17	20,029,475 (GRCm38)	missense	probably benign	0.01
R7514:Vmn2r104	UTSW	17	20,029,529 (GRCm38)	missense	probably damaging	1.00
R7634:Vmn2r104	UTSW	17	20,041,709 (GRCm38)	missense	possibly damaging	0.48
R7958:Vmn2r104	UTSW	17	20,042,726 (GRCm38)	missense	probably benign
R8031:Vmn2r104	UTSW	17	20,042,786 (GRCm38)	missense	probably benign	0.34
R8094:Vmn2r104	UTSW	17	20,030,221 (GRCm38)	missense	possibly damaging	0.77
R8191:Vmn2r104	UTSW	17	20,030,203 (GRCm38)	missense	possibly damaging	0.89
R8308:Vmn2r104	UTSW	17	20,040,778 (GRCm38)	missense	possibly damaging	0.55
R8691:Vmn2r104	UTSW	17	20,041,848 (GRCm38)	missense	probably damaging	0.98
R8795:Vmn2r104	UTSW	17	20,042,726 (GRCm38)	missense	probably benign
R8900:Vmn2r104	UTSW	17	20,041,662 (GRCm38)	missense	probably damaging	0.99
R8913:Vmn2r104	UTSW	17	20,029,706 (GRCm38)	missense	probably damaging	1.00
R9180:Vmn2r104	UTSW	17	20,042,825 (GRCm38)	missense	probably benign	0.00
R9199:Vmn2r104	UTSW	17	20,041,835 (GRCm38)	missense	probably damaging	0.99
R9282:Vmn2r104	UTSW	17	20,040,836 (GRCm38)	missense	probably damaging	1.00
R9303:Vmn2r104	UTSW	17	20,048,177 (GRCm38)	missense	possibly damaging	0.90
R9305:Vmn2r104	UTSW	17	20,048,177 (GRCm38)	missense	possibly damaging	0.90
R9322:Vmn2r104	UTSW	17	20,042,825 (GRCm38)	missense	probably benign	0.00
R9325:Vmn2r104	UTSW	17	20,048,171 (GRCm38)	missense	possibly damaging	0.95
R9414:Vmn2r104	UTSW	17	20,029,988 (GRCm38)	missense	probably damaging	0.99
R9785:Vmn2r104	UTSW	17	20,048,147 (GRCm38)	missense	probably benign
RF007:Vmn2r104	UTSW	17	20,048,040 (GRCm38)	missense	probably benign	0.36
Z1177:Vmn2r104	UTSW	17	20,029,789 (GRCm38)	missense	probably damaging	1.00

Posted On

2016-08-02