Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03261:Zfp236'

414826

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp236

Ensembl Gene

ENSMUSG00000041258

Gene Name

zinc finger protein 236

Synonyms

LOC240456

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL03261

Quality Score

Status

Chromosome

Chromosomal Location

82593593-82692883 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 82630608 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 916 (D916G)

Ref Sequence

ENSEMBL: ENSMUSP00000130004 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171071] [ENSMUST00000182122] [ENSMUST00000183048]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171071
AA Change: D916G

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000130004
Gene: ENSMUSG00000041258
AA Change: D916G

Domain	Start	End	E-Value	Type
ZnF_C2H2	39	61	2.24e-3	SMART
ZnF_C2H2	68	90	2.29e0	SMART
ZnF_C2H2	95	117	1.26e-2	SMART
ZnF_C2H2	123	145	6.67e-2	SMART
ZnF_C2H2	155	177	6.42e-4	SMART
ZnF_C2H2	199	221	1.75e-5	SMART
ZnF_C2H2	227	249	1.52e-5	SMART
ZnF_C2H2	255	278	8.94e-3	SMART
low complexity region	290	309	N/A	INTRINSIC
low complexity region	403	426	N/A	INTRINSIC
ZnF_C2H2	436	458	1.98e-4	SMART
ZnF_C2H2	464	486	9.58e-3	SMART
ZnF_C2H2	492	514	6.42e-4	SMART
ZnF_C2H2	520	542	1.18e-2	SMART
low complexity region	592	605	N/A	INTRINSIC
ZnF_C2H2	611	633	1.62e0	SMART
ZnF_C2H2	639	661	5.21e-4	SMART
ZnF_C2H2	667	689	6.78e-3	SMART
ZnF_C2H2	695	717	7.37e-4	SMART
low complexity region	720	733	N/A	INTRINSIC
ZnF_C2H2	922	944	5.21e-4	SMART
ZnF_C2H2	950	972	1.04e-3	SMART
ZnF_C2H2	978	1000	8.6e-5	SMART
ZnF_C2H2	1006	1028	2.75e-3	SMART
low complexity region	1030	1039	N/A	INTRINSIC
ZnF_C2H2	1122	1144	7.78e-3	SMART
ZnF_C2H2	1150	1172	3.63e-3	SMART
ZnF_C2H2	1178	1200	6.88e-4	SMART
ZnF_C2H2	1206	1228	5.42e-2	SMART
low complexity region	1243	1258	N/A	INTRINSIC
low complexity region	1462	1477	N/A	INTRINSIC
ZnF_C2H2	1612	1635	7.15e-2	SMART
ZnF_C2H2	1641	1663	2.91e-2	SMART
ZnF_C2H2	1677	1699	7.26e-3	SMART
ZnF_C2H2	1705	1727	1.84e-4	SMART
ZnF_C2H2	1733	1756	2.95e-3	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000182122
AA Change: D964G

PolyPhen 2 Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000138557
Gene: ENSMUSG00000041258
AA Change: D964G

Domain	Start	End	E-Value	Type
ZnF_C2H2	39	61	2.24e-3	SMART
ZnF_C2H2	68	90	2.29e0	SMART
ZnF_C2H2	95	117	1.26e-2	SMART
ZnF_C2H2	123	145	6.67e-2	SMART
ZnF_C2H2	155	177	6.42e-4	SMART
ZnF_C2H2	199	221	1.75e-5	SMART
ZnF_C2H2	227	249	1.52e-5	SMART
ZnF_C2H2	255	278	8.94e-3	SMART
ZnF_C2H2	287	310	9.58e-3	SMART
low complexity region	338	357	N/A	INTRINSIC
low complexity region	451	474	N/A	INTRINSIC
ZnF_C2H2	484	506	1.98e-4	SMART
ZnF_C2H2	512	534	9.58e-3	SMART
ZnF_C2H2	540	562	6.42e-4	SMART
ZnF_C2H2	568	590	1.18e-2	SMART
low complexity region	640	653	N/A	INTRINSIC
ZnF_C2H2	659	681	1.62e0	SMART
ZnF_C2H2	687	709	5.21e-4	SMART
ZnF_C2H2	715	737	6.78e-3	SMART
ZnF_C2H2	743	765	7.37e-4	SMART
low complexity region	768	781	N/A	INTRINSIC
ZnF_C2H2	970	992	5.21e-4	SMART
ZnF_C2H2	998	1020	1.04e-3	SMART
ZnF_C2H2	1026	1048	8.6e-5	SMART
ZnF_C2H2	1054	1076	2.75e-3	SMART
low complexity region	1078	1087	N/A	INTRINSIC
ZnF_C2H2	1170	1192	7.78e-3	SMART
ZnF_C2H2	1198	1220	3.63e-3	SMART
ZnF_C2H2	1226	1248	6.88e-4	SMART
ZnF_C2H2	1254	1276	5.42e-2	SMART
low complexity region	1291	1306	N/A	INTRINSIC
low complexity region	1510	1525	N/A	INTRINSIC
ZnF_C2H2	1660	1683	7.15e-2	SMART
ZnF_C2H2	1689	1711	2.91e-2	SMART
ZnF_C2H2	1725	1747	7.26e-3	SMART
ZnF_C2H2	1753	1775	1.84e-4	SMART
ZnF_C2H2	1781	1804	2.95e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000183048

SMART Domains

Protein: ENSMUSP00000138179
Gene: ENSMUSG00000041258

Domain	Start	End	E-Value	Type
ZnF_C2H2	39	61	2.24e-3	SMART
ZnF_C2H2	68	90	2.29e0	SMART
ZnF_C2H2	95	117	1.26e-2	SMART
ZnF_C2H2	123	145	6.67e-2	SMART
ZnF_C2H2	155	177	6.42e-4	SMART
ZnF_C2H2	199	221	1.75e-5	SMART
ZnF_C2H2	227	249	1.52e-5	SMART
ZnF_C2H2	255	278	8.94e-3	SMART
ZnF_C2H2	287	310	9.58e-3	SMART
low complexity region	338	357	N/A	INTRINSIC
low complexity region	454	467	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310022A10Rik	T	G	7: 27,580,438	Y281*	probably null	Het
5830411N06Rik	A	G	7: 140,294,833	H408R	probably benign	Het
Adamts3	T	C	5: 89,882,897		probably benign	Het
Afp	T	C	5: 90,491,751		probably null	Het
Ap1g2	T	C	14: 55,100,530	T634A	probably benign	Het
Cidec	A	G	6: 113,433,172	V32A	probably benign	Het
Dip2a	G	A	10: 76,305,148	P315S	possibly damaging	Het
Hoxc11	T	C	15: 102,954,743	V73A	probably benign	Het
Jmjd1c	A	G	10: 67,232,070	Y1784C	probably damaging	Het
Mmp21	A	G	7: 133,674,674	V480A	probably benign	Het
Nek4	C	T	14: 30,975,290	T471I	probably benign	Het
Nr4a2	A	G	2: 57,110,187	V299A	probably benign	Het
Olfr761	A	T	17: 37,952,806	S73T	possibly damaging	Het
Olfr774	A	G	10: 129,238,403	T85A	possibly damaging	Het
Ptprg	A	G	14: 12,225,552	D505G	probably damaging	Het
Rag2	A	G	2: 101,630,263	D306G	probably damaging	Het
Rpap2	T	A	5: 107,598,560	S38T	possibly damaging	Het
Scgb2b7	A	T	7: 31,705,081	C65S	probably damaging	Het
Slx4ip	A	T	2: 137,046,739	R113S	probably benign	Het
Smyd5	T	A	6: 85,432,018	M5K	probably benign	Het
Stkld1	A	T	2: 26,952,777	H587L	probably benign	Het
Taf4b	A	G	18: 14,821,528	T554A	probably benign	Het
Tex16	C	A	X: 112,118,855	D350E	possibly damaging	Het
Tex38	T	C	4: 115,780,526	K27E	possibly damaging	Het
Trdv4	T	C	14: 54,075,418	L83P	possibly damaging	Het
Ugt2a3	G	A	5: 87,336,580	P195L	probably damaging	Het
Vmn1r120	A	G	7: 21,053,525	L87P	probably damaging	Het

Other mutations in Zfp236

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01016:Zfp236	APN	18	82668690	missense	probably benign	0.44
IGL01760:Zfp236	APN	18	82621422	missense	probably damaging	1.00
IGL01923:Zfp236	APN	18	82682219	missense	probably damaging	0.98
IGL01934:Zfp236	APN	18	82633120	missense	probably damaging	0.99
IGL01949:Zfp236	APN	18	82624396	missense	probably damaging	1.00
IGL02063:Zfp236	APN	18	82658151	missense	probably benign
IGL02496:Zfp236	APN	18	82629992	missense	probably damaging	1.00
IGL02513:Zfp236	APN	18	82630114	missense	probably damaging	1.00
IGL02626:Zfp236	APN	18	82657995	splice site	probably benign
IGL02880:Zfp236	APN	18	82624459	missense	probably benign	0.15
IGL03156:Zfp236	APN	18	82680702	missense	probably damaging	1.00
R0047:Zfp236	UTSW	18	82680692	missense	probably damaging	1.00
R0052:Zfp236	UTSW	18	82639332	missense	probably damaging	1.00
R0194:Zfp236	UTSW	18	82656987	missense	probably damaging	1.00
R0207:Zfp236	UTSW	18	82640227	missense	probably damaging	1.00
R0234:Zfp236	UTSW	18	82629994	missense	probably damaging	1.00
R0234:Zfp236	UTSW	18	82629994	missense	probably damaging	1.00
R0302:Zfp236	UTSW	18	82658088	missense	probably damaging	0.99
R0730:Zfp236	UTSW	18	82640244	splice site	probably benign
R0755:Zfp236	UTSW	18	82620332	missense	probably damaging	1.00
R1202:Zfp236	UTSW	18	82628166	missense	probably benign	0.00
R1449:Zfp236	UTSW	18	82646005	missense	probably damaging	1.00
R1550:Zfp236	UTSW	18	82674424	missense	possibly damaging	0.81
R1785:Zfp236	UTSW	18	82621304	missense	probably benign	0.08
R1786:Zfp236	UTSW	18	82621304	missense	probably benign	0.08
R2042:Zfp236	UTSW	18	82633109	missense	probably damaging	1.00
R2132:Zfp236	UTSW	18	82621304	missense	probably benign	0.08
R2133:Zfp236	UTSW	18	82621304	missense	probably benign	0.08
R2247:Zfp236	UTSW	18	82604298	missense	possibly damaging	0.82
R2484:Zfp236	UTSW	18	82668637	missense	probably benign	0.05
R3715:Zfp236	UTSW	18	82632970	splice site	probably benign
R4003:Zfp236	UTSW	18	82680745	nonsense	probably null
R4031:Zfp236	UTSW	18	82624465	missense	probably damaging	1.00
R4482:Zfp236	UTSW	18	82644221	missense	probably benign	0.04
R4492:Zfp236	UTSW	18	82630000	missense	probably damaging	1.00
R4502:Zfp236	UTSW	18	82636954	missense	probably benign	0.13
R4561:Zfp236	UTSW	18	82620406	missense	probably damaging	1.00
R4649:Zfp236	UTSW	18	82597659	missense	probably damaging	1.00
R4902:Zfp236	UTSW	18	82609418	missense	possibly damaging	0.89
R5064:Zfp236	UTSW	18	82691576	critical splice donor site	probably null
R5084:Zfp236	UTSW	18	82609431	missense	probably damaging	1.00
R5090:Zfp236	UTSW	18	82618881	missense	probably benign	0.08
R5191:Zfp236	UTSW	18	82621423	missense	probably damaging	1.00
R5264:Zfp236	UTSW	18	82630094	missense	probably damaging	1.00
R5264:Zfp236	UTSW	18	82658073	missense	probably damaging	0.99
R5339:Zfp236	UTSW	18	82624366	missense	probably damaging	0.99
R5375:Zfp236	UTSW	18	82597688	missense	possibly damaging	0.93
R5445:Zfp236	UTSW	18	82682156	missense	probably benign	0.02
R5513:Zfp236	UTSW	18	82658022	missense	probably damaging	0.97
R5527:Zfp236	UTSW	18	82658034	missense	possibly damaging	0.51
R5628:Zfp236	UTSW	18	82657122	missense	probably damaging	1.00
R5758:Zfp236	UTSW	18	82671709	missense	probably damaging	1.00
R5890:Zfp236	UTSW	18	82640151	missense	possibly damaging	0.87
R6137:Zfp236	UTSW	18	82671794	missense	possibly damaging	0.89
R6193:Zfp236	UTSW	18	82604247	missense	probably damaging	1.00
R6198:Zfp236	UTSW	18	82657153	missense	probably damaging	1.00
R6239:Zfp236	UTSW	18	82657104	missense	possibly damaging	0.53
R6705:Zfp236	UTSW	18	82633737	missense	probably damaging	0.97
R6948:Zfp236	UTSW	18	82644062	missense	possibly damaging	0.94
R6989:Zfp236	UTSW	18	82628363	missense	probably damaging	1.00
R7002:Zfp236	UTSW	18	82691576	critical splice donor site	probably null
R7113:Zfp236	UTSW	18	82620337	missense	possibly damaging	0.82
R7261:Zfp236	UTSW	18	82609345	missense	possibly damaging	0.86
R7363:Zfp236	UTSW	18	82621331	missense	probably damaging	1.00
R7447:Zfp236	UTSW	18	82633690	missense	probably damaging	1.00
R7564:Zfp236	UTSW	18	82644241	nonsense	probably null
R7731:Zfp236	UTSW	18	82680673	missense	probably benign	0.27
R7857:Zfp236	UTSW	18	82668601	nonsense	probably null
R7860:Zfp236	UTSW	18	82674356	nonsense	probably null
R7904:Zfp236	UTSW	18	82609382	missense	possibly damaging	0.90
R7948:Zfp236	UTSW	18	82624415	missense	probably damaging	1.00
R7995:Zfp236	UTSW	18	82639336	missense	probably damaging	1.00
R8153:Zfp236	UTSW	18	82630027	missense	probably damaging	1.00
R8435:Zfp236	UTSW	18	82640241	missense	probably damaging	1.00

Posted On

2016-08-02