Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03226:Ifna16'

414829

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna16

Ensembl Gene

ENSMUSG00000078355

Gene Name

interferon alpha 16

Synonyms

Gm13280, Ifna6t

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL03226

Quality Score

Status

Chromosome

Chromosomal Location

88594524-88595093 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 88594741 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 118 (D118G)

Ref Sequence

ENSEMBL: ENSMUSP00000100779 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105148]

AlphaFold

Q810G1

Predicted Effect

probably benign
Transcript: ENSMUST00000105148
AA Change: D118G

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000100779
Gene: ENSMUSG00000078355
AA Change: D118G

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	2.69e-66	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9930012K11Rik	A	G	14: 70,395,058 (GRCm39)	V32A	probably damaging	Het
Als2	T	C	1: 59,225,679 (GRCm39)	T944A	probably benign	Het
Bcat2	T	A	7: 45,237,778 (GRCm39)	V348E	probably damaging	Het
Bnip2	A	G	9: 69,903,456 (GRCm39)	D36G	probably benign	Het
C2cd5	T	A	6: 143,018,292 (GRCm39)	D310V	possibly damaging	Het
Cltc	G	A	11: 86,611,113 (GRCm39)	T582M	probably damaging	Het
Cplx3	A	T	9: 57,517,290 (GRCm39)	Y365N	probably benign	Het
Dync2h1	T	C	9: 7,125,918 (GRCm39)	H1896R	probably benign	Het
Efcab5	T	C	11: 77,028,501 (GRCm39)	R413G	possibly damaging	Het
Fam131b	C	T	6: 42,295,888 (GRCm39)	M169I	possibly damaging	Het
Fam241b	A	G	10: 61,945,671 (GRCm39)	S52P	probably benign	Het
Gpd2	G	A	2: 57,194,498 (GRCm39)		probably null	Het
Gucy1a1	T	A	3: 82,026,331 (GRCm39)	Q41L	probably benign	Het
Kcnn1	T	C	8: 71,299,135 (GRCm39)		probably benign	Het
Lyl1	C	T	8: 85,429,300 (GRCm39)	P3L	possibly damaging	Het
Lyst	A	T	13: 13,884,144 (GRCm39)	H2984L	probably benign	Het
Myh7b	C	T	2: 155,462,403 (GRCm39)	Q369*	probably null	Het
Nalcn	A	C	14: 123,518,527 (GRCm39)	W1671G	probably benign	Het
Ndrg2	G	A	14: 52,144,026 (GRCm39)		probably benign	Het
Nfia	C	A	4: 97,951,286 (GRCm39)	P371Q	probably damaging	Het
Or10d5	A	C	9: 39,861,719 (GRCm39)		probably null	Het
Pcdhb22	A	G	18: 37,652,009 (GRCm39)	D159G	probably damaging	Het
Plekhm3	A	T	1: 64,960,959 (GRCm39)	D432E	possibly damaging	Het
Pramel17	T	A	4: 101,692,594 (GRCm39)	T469S	probably benign	Het
Rab2a	A	G	4: 8,606,448 (GRCm39)	N195S	probably benign	Het
Sbf1	A	G	15: 89,173,308 (GRCm39)	Y1764H	possibly damaging	Het
Scap	A	G	9: 110,213,335 (GRCm39)	T1127A	possibly damaging	Het
Shld2	T	C	14: 33,990,328 (GRCm39)	T193A	probably benign	Het
Slc45a2	A	G	15: 11,022,278 (GRCm39)	D340G	probably damaging	Het
Tbc1d23	A	T	16: 57,034,625 (GRCm39)	L58Q	probably damaging	Het
Tmcc1	T	C	6: 116,110,937 (GRCm39)	T119A	probably damaging	Het
Tnfsf10	C	A	3: 27,389,597 (GRCm39)	Y219*	probably null	Het
Traip	G	A	9: 107,848,192 (GRCm39)	R437Q	probably damaging	Het
Tyw3	T	C	3: 154,293,187 (GRCm39)	T163A	possibly damaging	Het

Other mutations in Ifna16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01085:Ifna16	APN	4	88,594,969 (GRCm39)	missense	probably benign
IGL01779:Ifna16	APN	4	88,594,882 (GRCm39)	missense	probably damaging	1.00
IGL02717:Ifna16	APN	4	88,594,777 (GRCm39)	missense	possibly damaging	0.95
R0040:Ifna16	UTSW	4	88,594,867 (GRCm39)	missense	probably benign	0.35
R0040:Ifna16	UTSW	4	88,594,867 (GRCm39)	missense	probably benign	0.35
R1514:Ifna16	UTSW	4	88,594,979 (GRCm39)	missense	possibly damaging	0.84
R2341:Ifna16	UTSW	4	88,594,565 (GRCm39)	missense	probably damaging	1.00
R4877:Ifna16	UTSW	4	88,594,681 (GRCm39)	missense	probably benign	0.00
R8989:Ifna16	UTSW	4	88,594,912 (GRCm39)	missense	probably damaging	1.00
R9619:Ifna16	UTSW	4	88,594,762 (GRCm39)	missense	probably benign	0.30
R9648:Ifna16	UTSW	4	88,595,060 (GRCm39)	missense	probably benign	0.18
R9688:Ifna16	UTSW	4	88,594,874 (GRCm39)	nonsense	probably null
R9743:Ifna16	UTSW	4	88,594,930 (GRCm39)	missense	probably damaging	1.00
Z1088:Ifna16	UTSW	4	88,594,615 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02