Incidental Mutation 'R0463:Trpm1'
| ID |
41483 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trpm1
|
| Ensembl Gene |
ENSMUSG00000030523 |
| Gene Name |
transient receptor potential cation channel, subfamily M, member 1 |
| Synonyms |
Mlsn1, 4732499L03Rik, LTRPC1, melastatin |
| MMRRC Submission |
038663-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0463 (G1)
|
| Quality Score |
210 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
64153835-64269775 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 64220254 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Serine
at position 436
(P436S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134947
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000085222]
[ENSMUST00000177102]
[ENSMUST00000205348]
[ENSMUST00000205731]
[ENSMUST00000205994]
[ENSMUST00000206263]
[ENSMUST00000206277]
[ENSMUST00000206314]
[ENSMUST00000206706]
|
| AlphaFold |
Q2TV84 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000085222
AA Change: P552S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000082318
Gene: ENSMUSG00000030523
AA Change: P552S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
transmembrane domain
|
876 |
895 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
907 |
1120 |
6e-16 |
PFAM |
|
transmembrane domain
|
1150 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1216 |
1225 |
N/A |
INTRINSIC |
|
PDB:3E7K|H
|
1228 |
1279 |
1e-7 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107525
AA Change: P552S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000103149
Gene: ENSMUSG00000030523
AA Change: P552S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
876 |
1138 |
7.6e-22 |
PFAM |
|
transmembrane domain
|
1156 |
1173 |
N/A |
INTRINSIC |
|
Pfam:TRPM_tetra
|
1230 |
1285 |
9.4e-28 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177102
AA Change: P436S
PolyPhen 2
Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000134947
Gene: ENSMUSG00000030523
AA Change: P436S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
67 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
191 |
N/A |
INTRINSIC |
|
low complexity region
|
340 |
375 |
N/A |
INTRINSIC |
|
Blast:ANK
|
389 |
417 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205348
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205434
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205610
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205731
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205994
AA Change: P60S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206263
AA Change: P436S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206277
AA Change: P552S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206314
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206740
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206706
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
A |
G |
5: 109,737,060 (GRCm38) |
|
probably benign |
Het |
| Abcd2 |
C |
T |
15: 91,159,124 (GRCm38) |
M620I |
probably benign |
Het |
| Ada |
T |
A |
2: 163,730,351 (GRCm38) |
I243F |
probably benign |
Het |
| Adam12 |
T |
C |
7: 133,974,416 (GRCm38) |
|
probably null |
Het |
| Adarb2 |
A |
T |
13: 8,203,188 (GRCm38) |
|
probably benign |
Het |
| Adk |
A |
C |
14: 21,423,536 (GRCm38) |
Q287P |
probably benign |
Het |
| Ahnak |
A |
G |
19: 9,009,407 (GRCm38) |
|
probably benign |
Het |
| Aoc3 |
C |
T |
11: 101,331,606 (GRCm38) |
R223W |
probably damaging |
Het |
| Aqp11 |
T |
C |
7: 97,729,021 (GRCm38) |
D229G |
probably benign |
Het |
| Arhgap28 |
A |
G |
17: 67,896,225 (GRCm38) |
S78P |
probably damaging |
Het |
| Bfsp2 |
T |
A |
9: 103,426,655 (GRCm38) |
E383D |
possibly damaging |
Het |
| Bmpr1b |
A |
T |
3: 141,857,430 (GRCm38) |
V251D |
possibly damaging |
Het |
| Calhm1 |
C |
T |
19: 47,143,841 (GRCm38) |
V112I |
probably benign |
Het |
| Catsperd |
A |
G |
17: 56,659,554 (GRCm38) |
D508G |
probably damaging |
Het |
| Cfap54 |
A |
G |
10: 92,874,943 (GRCm38) |
|
probably null |
Het |
| Cfap70 |
A |
T |
14: 20,448,563 (GRCm38) |
Y19N |
probably damaging |
Het |
| Chga |
A |
T |
12: 102,562,951 (GRCm38) |
R396* |
probably null |
Het |
| Cntnap3 |
T |
C |
13: 64,778,876 (GRCm38) |
E560G |
probably damaging |
Het |
| Csmd1 |
T |
C |
8: 15,921,759 (GRCm38) |
T3024A |
probably damaging |
Het |
| Csrnp1 |
CCCTCCTCCTCCTCCTCCTC |
CCCTCCTCCTCCTCCTC |
9: 119,972,775 (GRCm38) |
|
probably benign |
Het |
| Cysltr1 |
A |
G |
X: 106,578,655 (GRCm38) |
V75A |
possibly damaging |
Het |
| Dnah2 |
A |
T |
11: 69,423,126 (GRCm38) |
M4140K |
probably damaging |
Het |
| Dph5 |
A |
G |
3: 115,928,703 (GRCm38) |
S277G |
probably benign |
Het |
| Eftud2 |
A |
T |
11: 102,864,771 (GRCm38) |
D203E |
probably damaging |
Het |
| Egf |
A |
G |
3: 129,706,233 (GRCm38) |
Y252H |
probably benign |
Het |
| Egf |
A |
G |
3: 129,737,549 (GRCm38) |
S126P |
probably damaging |
Het |
| Faf1 |
C |
T |
4: 109,890,941 (GRCm38) |
A481V |
probably benign |
Het |
| Fat2 |
A |
T |
11: 55,262,829 (GRCm38) |
V3519D |
probably damaging |
Het |
| Fbln7 |
C |
A |
2: 128,877,511 (GRCm38) |
A76E |
probably benign |
Het |
| Galnt1 |
A |
T |
18: 24,254,525 (GRCm38) |
K49N |
probably benign |
Het |
| Glb1 |
ACCC |
ACC |
9: 114,421,744 (GRCm38) |
|
probably null |
Het |
| Grk1 |
T |
C |
8: 13,409,279 (GRCm38) |
Y277H |
probably damaging |
Het |
| Hap1 |
A |
G |
11: 100,349,305 (GRCm38) |
L555P |
probably damaging |
Het |
| Ier3 |
T |
C |
17: 35,822,108 (GRCm38) |
I94T |
possibly damaging |
Het |
| Il11 |
T |
C |
7: 4,776,024 (GRCm38) |
T36A |
probably damaging |
Het |
| Il5ra |
A |
T |
6: 106,731,890 (GRCm38) |
D296E |
probably damaging |
Het |
| Itk |
A |
T |
11: 46,331,989 (GRCm38) |
V551E |
probably damaging |
Het |
| Kcna2 |
T |
A |
3: 107,105,160 (GRCm38) |
D352E |
probably benign |
Het |
| Kif5a |
A |
T |
10: 127,235,652 (GRCm38) |
S776T |
probably benign |
Het |
| Klrb1c |
T |
C |
6: 128,780,403 (GRCm38) |
E233G |
probably benign |
Het |
| Kpna7 |
T |
C |
5: 145,007,994 (GRCm38) |
K12R |
possibly damaging |
Het |
| Lhpp |
C |
T |
7: 132,610,677 (GRCm38) |
|
probably benign |
Het |
| Lhx8 |
A |
T |
3: 154,328,171 (GRCm38) |
|
probably null |
Het |
| Lrrc6 |
T |
A |
15: 66,380,474 (GRCm38) |
M448L |
probably benign |
Het |
| Magel2 |
T |
A |
7: 62,378,030 (GRCm38) |
H227Q |
possibly damaging |
Het |
| Man1a |
A |
G |
10: 54,074,498 (GRCm38) |
V176A |
probably damaging |
Het |
| Mapkbp1 |
T |
A |
2: 120,023,151 (GRCm38) |
M1152K |
probably benign |
Het |
| Mcoln3 |
T |
A |
3: 146,140,576 (GRCm38) |
L547* |
probably null |
Het |
| Myof |
T |
C |
19: 37,916,504 (GRCm38) |
D1624G |
probably damaging |
Het |
| Myom2 |
T |
C |
8: 15,104,123 (GRCm38) |
V687A |
probably benign |
Het |
| Nav1 |
C |
A |
1: 135,452,207 (GRCm38) |
V1586F |
possibly damaging |
Het |
| Ndufb8 |
T |
C |
19: 44,550,345 (GRCm38) |
E179G |
possibly damaging |
Het |
| Nfam1 |
T |
C |
15: 83,001,483 (GRCm38) |
T223A |
probably damaging |
Het |
| Nrcam |
T |
A |
12: 44,551,341 (GRCm38) |
V371E |
probably damaging |
Het |
| Nup210l |
A |
G |
3: 90,180,211 (GRCm38) |
Q1097R |
probably null |
Het |
| Obox5 |
T |
A |
7: 15,757,646 (GRCm38) |
M37K |
probably damaging |
Het |
| Obscn |
A |
T |
11: 59,061,530 (GRCm38) |
N4270K |
probably benign |
Het |
| Olfr1008 |
T |
C |
2: 85,689,839 (GRCm38) |
S137P |
possibly damaging |
Het |
| Olfr463 |
G |
A |
11: 87,893,196 (GRCm38) |
H243Y |
probably damaging |
Het |
| Olfr802 |
A |
G |
10: 129,681,839 (GRCm38) |
M300T |
probably benign |
Het |
| Olfr893 |
G |
A |
9: 38,209,064 (GRCm38) |
A2T |
probably benign |
Het |
| Olfr995 |
T |
A |
2: 85,438,286 (GRCm38) |
S291C |
probably damaging |
Het |
| Patj |
G |
A |
4: 98,674,308 (GRCm38) |
E1505K |
probably damaging |
Het |
| Pnliprp1 |
T |
A |
19: 58,738,196 (GRCm38) |
Y328* |
probably null |
Het |
| Ppp1r36 |
G |
A |
12: 76,418,967 (GRCm38) |
E43K |
probably damaging |
Het |
| Ptch1 |
C |
T |
13: 63,520,307 (GRCm38) |
V939I |
probably damaging |
Het |
| Rgs22 |
C |
A |
15: 36,092,938 (GRCm38) |
K396N |
probably damaging |
Het |
| Rsrc1 |
A |
T |
3: 67,180,861 (GRCm38) |
H176L |
probably damaging |
Het |
| Ryr3 |
A |
T |
2: 112,661,701 (GRCm38) |
F3743L |
probably damaging |
Het |
| Scn7a |
C |
T |
2: 66,675,740 (GRCm38) |
G1602R |
probably benign |
Het |
| Sftpc |
A |
T |
14: 70,522,670 (GRCm38) |
V49E |
probably damaging |
Het |
| Slc16a10 |
A |
G |
10: 40,040,616 (GRCm38) |
V430A |
probably benign |
Het |
| Slco4c1 |
A |
C |
1: 96,867,920 (GRCm38) |
S138A |
possibly damaging |
Het |
| Snd1 |
T |
C |
6: 28,724,956 (GRCm38) |
I501T |
probably benign |
Het |
| Stxbp2 |
T |
A |
8: 3,632,559 (GRCm38) |
D49E |
probably damaging |
Het |
| Sytl4 |
A |
T |
X: 133,962,187 (GRCm38) |
D16E |
probably benign |
Het |
| Tbc1d9b |
G |
A |
11: 50,145,067 (GRCm38) |
G130E |
probably benign |
Het |
| Tdrd6 |
T |
A |
17: 43,625,561 (GRCm38) |
D1532V |
probably damaging |
Het |
| Tekt1 |
T |
C |
11: 72,351,952 (GRCm38) |
D243G |
probably damaging |
Het |
| Tet2 |
A |
G |
3: 133,486,666 (GRCm38) |
L669S |
possibly damaging |
Het |
| Tnnt3 |
A |
G |
7: 142,512,335 (GRCm38) |
N201S |
probably benign |
Het |
| Trdn |
A |
G |
10: 33,466,421 (GRCm38) |
|
probably null |
Het |
| Trim36 |
T |
C |
18: 46,178,456 (GRCm38) |
E259G |
possibly damaging |
Het |
| Vmn1r183 |
T |
A |
7: 24,055,501 (GRCm38) |
L243Q |
probably damaging |
Het |
| Vps13b |
T |
C |
15: 35,597,409 (GRCm38) |
S1032P |
probably damaging |
Het |
| Vps37d |
T |
C |
5: 135,076,541 (GRCm38) |
E76G |
probably damaging |
Het |
| Vps72 |
A |
G |
3: 95,121,304 (GRCm38) |
H202R |
probably benign |
Het |
| Wdr75 |
T |
C |
1: 45,819,602 (GRCm38) |
S644P |
probably damaging |
Het |
| Wrn |
T |
A |
8: 33,280,815 (GRCm38) |
E697V |
possibly damaging |
Het |
| Xirp2 |
A |
G |
2: 67,514,918 (GRCm38) |
D2501G |
probably benign |
Het |
| Zfp472 |
T |
C |
17: 32,975,962 (GRCm38) |
W24R |
probably damaging |
Het |
| Zmym6 |
T |
C |
4: 127,122,772 (GRCm38) |
V782A |
probably damaging |
Het |
|
| Other mutations in Trpm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00093:Trpm1
|
APN |
7 |
64,243,450 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00465:Trpm1
|
APN |
7 |
64,247,467 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL01118:Trpm1
|
APN |
7 |
64,235,824 (GRCm38) |
missense |
probably benign |
0.24 |
|
IGL01148:Trpm1
|
APN |
7 |
64,243,564 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01303:Trpm1
|
APN |
7 |
64,210,830 (GRCm38) |
critical splice acceptor site |
probably benign |
0.00 |
|
IGL01432:Trpm1
|
APN |
7 |
64,235,019 (GRCm38) |
missense |
probably benign |
0.18 |
|
IGL01433:Trpm1
|
APN |
7 |
64,204,528 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01506:Trpm1
|
APN |
7 |
64,243,581 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01626:Trpm1
|
APN |
7 |
64,268,889 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01640:Trpm1
|
APN |
7 |
64,226,897 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01899:Trpm1
|
APN |
7 |
64,234,994 (GRCm38) |
missense |
probably benign |
0.24 |
|
IGL01959:Trpm1
|
APN |
7 |
64,208,975 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
IGL02210:Trpm1
|
APN |
7 |
64,210,865 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02268:Trpm1
|
APN |
7 |
64,217,614 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02331:Trpm1
|
APN |
7 |
64,235,052 (GRCm38) |
missense |
probably benign |
0.30 |
|
IGL02334:Trpm1
|
APN |
7 |
64,245,942 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
IGL02407:Trpm1
|
APN |
7 |
64,219,121 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02425:Trpm1
|
APN |
7 |
64,240,427 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02485:Trpm1
|
APN |
7 |
64,269,114 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
IGL02635:Trpm1
|
APN |
7 |
64,199,224 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02640:Trpm1
|
APN |
7 |
64,219,133 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02827:Trpm1
|
APN |
7 |
64,219,160 (GRCm38) |
missense |
probably null |
1.00 |
|
PIT4458001:Trpm1
|
UTSW |
7 |
64,268,561 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
PIT4544001:Trpm1
|
UTSW |
7 |
64,199,250 (GRCm38) |
intron |
probably benign |
|
|
R0012:Trpm1
|
UTSW |
7 |
64,268,591 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0014:Trpm1
|
UTSW |
7 |
64,248,222 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0056:Trpm1
|
UTSW |
7 |
64,243,586 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0445:Trpm1
|
UTSW |
7 |
64,244,842 (GRCm38) |
unclassified |
probably benign |
|
|
R0469:Trpm1
|
UTSW |
7 |
64,223,758 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0510:Trpm1
|
UTSW |
7 |
64,223,758 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1301:Trpm1
|
UTSW |
7 |
64,203,053 (GRCm38) |
splice site |
probably null |
|
|
R1397:Trpm1
|
UTSW |
7 |
64,217,658 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1588:Trpm1
|
UTSW |
7 |
64,223,817 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R1618:Trpm1
|
UTSW |
7 |
64,240,535 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1724:Trpm1
|
UTSW |
7 |
64,235,821 (GRCm38) |
nonsense |
probably null |
|
|
R1827:Trpm1
|
UTSW |
7 |
64,235,007 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1829:Trpm1
|
UTSW |
7 |
64,226,782 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1835:Trpm1
|
UTSW |
7 |
64,230,268 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1864:Trpm1
|
UTSW |
7 |
64,268,016 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1895:Trpm1
|
UTSW |
7 |
64,223,808 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1946:Trpm1
|
UTSW |
7 |
64,223,808 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1959:Trpm1
|
UTSW |
7 |
64,230,230 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1960:Trpm1
|
UTSW |
7 |
64,230,230 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1980:Trpm1
|
UTSW |
7 |
64,208,434 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R1989:Trpm1
|
UTSW |
7 |
64,209,032 (GRCm38) |
intron |
probably null |
|
|
R2054:Trpm1
|
UTSW |
7 |
64,240,555 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R2156:Trpm1
|
UTSW |
7 |
64,234,988 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2251:Trpm1
|
UTSW |
7 |
64,209,976 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3051:Trpm1
|
UTSW |
7 |
64,269,101 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3148:Trpm1
|
UTSW |
7 |
64,235,012 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3195:Trpm1
|
UTSW |
7 |
64,199,313 (GRCm38) |
nonsense |
probably null |
|
|
R3615:Trpm1
|
UTSW |
7 |
64,243,570 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3616:Trpm1
|
UTSW |
7 |
64,243,570 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3623:Trpm1
|
UTSW |
7 |
64,244,853 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3624:Trpm1
|
UTSW |
7 |
64,244,853 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3721:Trpm1
|
UTSW |
7 |
64,217,727 (GRCm38) |
intron |
probably benign |
|
|
R3822:Trpm1
|
UTSW |
7 |
64,217,703 (GRCm38) |
intron |
probably benign |
|
|
R4441:Trpm1
|
UTSW |
7 |
64,201,918 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4490:Trpm1
|
UTSW |
7 |
64,208,912 (GRCm38) |
nonsense |
probably null |
|
|
R4666:Trpm1
|
UTSW |
7 |
64,203,034 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4701:Trpm1
|
UTSW |
7 |
64,243,500 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4781:Trpm1
|
UTSW |
7 |
64,235,052 (GRCm38) |
missense |
probably benign |
0.30 |
|
R4811:Trpm1
|
UTSW |
7 |
64,208,306 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5017:Trpm1
|
UTSW |
7 |
64,244,832 (GRCm38) |
unclassified |
probably benign |
|
|
R5030:Trpm1
|
UTSW |
7 |
64,235,831 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5195:Trpm1
|
UTSW |
7 |
64,237,693 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R5238:Trpm1
|
UTSW |
7 |
64,268,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5304:Trpm1
|
UTSW |
7 |
64,208,946 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5575:Trpm1
|
UTSW |
7 |
64,220,270 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5613:Trpm1
|
UTSW |
7 |
64,208,411 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5855:Trpm1
|
UTSW |
7 |
64,268,962 (GRCm38) |
nonsense |
probably null |
|
|
R5947:Trpm1
|
UTSW |
7 |
64,223,799 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5988:Trpm1
|
UTSW |
7 |
64,226,805 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6054:Trpm1
|
UTSW |
7 |
64,268,702 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6088:Trpm1
|
UTSW |
7 |
64,267,976 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6259:Trpm1
|
UTSW |
7 |
64,268,478 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R6379:Trpm1
|
UTSW |
7 |
64,199,194 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6380:Trpm1
|
UTSW |
7 |
64,268,297 (GRCm38) |
missense |
probably benign |
0.24 |
|
R6429:Trpm1
|
UTSW |
7 |
64,268,504 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6600:Trpm1
|
UTSW |
7 |
64,154,033 (GRCm38) |
start codon destroyed |
probably null |
0.56 |
|
R6622:Trpm1
|
UTSW |
7 |
64,240,595 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6939:Trpm1
|
UTSW |
7 |
64,268,297 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6944:Trpm1
|
UTSW |
7 |
64,243,433 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7025:Trpm1
|
UTSW |
7 |
64,226,714 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7112:Trpm1
|
UTSW |
7 |
64,235,845 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7168:Trpm1
|
UTSW |
7 |
64,268,697 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7219:Trpm1
|
UTSW |
7 |
64,204,585 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R7224:Trpm1
|
UTSW |
7 |
64,219,106 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7285:Trpm1
|
UTSW |
7 |
64,209,981 (GRCm38) |
nonsense |
probably null |
|
|
R7367:Trpm1
|
UTSW |
7 |
64,268,801 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7449:Trpm1
|
UTSW |
7 |
64,208,975 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7466:Trpm1
|
UTSW |
7 |
64,240,582 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7498:Trpm1
|
UTSW |
7 |
64,208,909 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7581:Trpm1
|
UTSW |
7 |
64,204,555 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7776:Trpm1
|
UTSW |
7 |
64,248,191 (GRCm38) |
missense |
probably benign |
0.04 |
|
R8062:Trpm1
|
UTSW |
7 |
64,201,941 (GRCm38) |
missense |
probably benign |
0.18 |
|
R8069:Trpm1
|
UTSW |
7 |
64,208,970 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R8157:Trpm1
|
UTSW |
7 |
64,199,269 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8219:Trpm1
|
UTSW |
7 |
64,201,951 (GRCm38) |
missense |
probably benign |
0.35 |
|
R8258:Trpm1
|
UTSW |
7 |
64,269,029 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8259:Trpm1
|
UTSW |
7 |
64,269,029 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8320:Trpm1
|
UTSW |
7 |
64,268,793 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R8536:Trpm1
|
UTSW |
7 |
64,247,407 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8544:Trpm1
|
UTSW |
7 |
64,224,608 (GRCm38) |
splice site |
probably null |
|
|
R8813:Trpm1
|
UTSW |
7 |
64,202,008 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R8912:Trpm1
|
UTSW |
7 |
64,268,880 (GRCm38) |
missense |
probably benign |
0.06 |
|
R8954:Trpm1
|
UTSW |
7 |
64,208,341 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9139:Trpm1
|
UTSW |
7 |
64,199,195 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9205:Trpm1
|
UTSW |
7 |
64,240,571 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R9258:Trpm1
|
UTSW |
7 |
64,234,965 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9283:Trpm1
|
UTSW |
7 |
64,223,875 (GRCm38) |
missense |
probably benign |
0.18 |
|
R9394:Trpm1
|
UTSW |
7 |
64,268,732 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9430:Trpm1
|
UTSW |
7 |
64,223,698 (GRCm38) |
missense |
probably benign |
0.38 |
|
R9537:Trpm1
|
UTSW |
7 |
64,153,868 (GRCm38) |
unclassified |
probably benign |
|
|
R9616:Trpm1
|
UTSW |
7 |
64,208,384 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9774:Trpm1
|
UTSW |
7 |
64,248,293 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
X0026:Trpm1
|
UTSW |
7 |
64,268,910 (GRCm38) |
missense |
probably benign |
0.05 |
|
Z1176:Trpm1
|
UTSW |
7 |
64,204,594 (GRCm38) |
critical splice donor site |
probably null |
|
|
Z1176:Trpm1
|
UTSW |
7 |
64,203,131 (GRCm38) |
critical splice donor site |
probably null |
|
|
Z1177:Trpm1
|
UTSW |
7 |
64,217,691 (GRCm38) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGTGGGGTAACCACAGCCAG -3'
(R):5'- GGGGCAGGTATCATACCCATCCAG -3'
Sequencing Primer
(F):5'- CCACAGCCAGTTGTCTTATAAAGG -3'
(R):5'- gagcacgcacaccacag -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation