Incidental Mutation 'IGL03251:Ppp2cb'
ID414936
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ppp2cb
Ensembl Gene ENSMUSG00000009630
Gene Nameprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
SynonymsPP2Ac, D8Ertd766e
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03251
Quality Score
Status
Chromosome8
Chromosomal Location33599625-33619441 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 33610651 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000009774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009774]
Predicted Effect probably benign
Transcript: ENSMUST00000009774
SMART Domains Protein: ENSMUSP00000009774
Gene: ENSMUSG00000009630

DomainStartEndE-ValueType
PP2Ac 23 293 2.48e-156 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 T C 7: 45,982,237 probably benign Het
Cdkl2 A G 5: 92,033,726 I132T probably damaging Het
Ckap4 A T 10: 84,528,605 I198N probably damaging Het
Col6a3 C T 1: 90,810,176 R600H probably damaging Het
Dnah7a A G 1: 53,647,274 I239T probably benign Het
Ei24 A G 9: 36,780,109 *359R probably null Het
Elk3 A T 10: 93,254,821 probably null Het
Eps8l2 T A 7: 141,342,962 M46K probably damaging Het
Frem2 G T 3: 53,572,308 T1988N probably benign Het
Gm5431 T C 11: 48,894,721 K276E probably benign Het
Gm8220 T A 14: 44,288,272 C133S possibly damaging Het
Hectd2 T C 19: 36,585,526 L168P probably damaging Het
Hydin A T 8: 110,490,596 D1372V probably damaging Het
Isl1 T C 13: 116,305,449 S83G probably benign Het
Lrp1b A G 2: 40,600,267 I107T probably benign Het
Mlc1 A T 15: 88,974,731 V117D possibly damaging Het
Ndc1 A G 4: 107,380,659 E220G possibly damaging Het
Nlrp4b T A 7: 10,714,500 M210K probably benign Het
Olfr372 A T 8: 72,058,076 Y132F probably damaging Het
Plch1 T C 3: 63,784,002 E60G possibly damaging Het
Pld1 G A 3: 28,088,665 R674H probably benign Het
Ppp1r13l G A 7: 19,368,869 probably benign Het
Rchy1 G T 5: 91,962,643 A26D probably benign Het
Rrm1 T C 7: 102,457,206 F311L probably damaging Het
Scrn1 G A 6: 54,548,337 R16* probably null Het
Slc24a4 T C 12: 102,222,825 L173P probably damaging Het
Srgap1 T C 10: 121,804,921 probably null Het
Tube1 T A 10: 39,134,981 probably benign Het
Utp20 C T 10: 88,817,326 probably null Het
Vmn2r55 T C 7: 12,671,193 probably benign Het
Other mutations in Ppp2cb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01566:Ppp2cb APN 8 33611763 missense probably benign 0.38
IGL02985:Ppp2cb APN 8 33615446 unclassified probably benign
Breakthrough UTSW 8 33615474 missense probably damaging 1.00
R0940:Ppp2cb UTSW 8 33615661 unclassified probably null
R1688:Ppp2cb UTSW 8 33615452 missense probably benign 0.02
R2187:Ppp2cb UTSW 8 33610677 missense possibly damaging 0.95
R2350:Ppp2cb UTSW 8 33611827 missense probably null 1.00
R4418:Ppp2cb UTSW 8 33617049 missense probably benign
R4566:Ppp2cb UTSW 8 33610695 missense possibly damaging 0.67
R6187:Ppp2cb UTSW 8 33615474 missense probably damaging 1.00
R6990:Ppp2cb UTSW 8 33619133 missense probably benign 0.01
R7477:Ppp2cb UTSW 8 33615474 missense probably benign 0.01
Posted On2016-08-02