Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03264:Vmn2r53'

414996

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r53

Ensembl Gene

ENSMUSG00000096002

Gene Name

vomeronasal 2, receptor 53

Synonyms

EG637908

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

IGL03264

Quality Score

Status

Chromosome

Chromosomal Location

12315397-12342583 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 12315819 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 667 (I667F)

Ref Sequence

ENSEMBL: ENSMUSP00000126979 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170412]

AlphaFold

A0A3B2W4A7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170412
AA Change: I667F

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000126979
Gene: ENSMUSG00000096002
AA Change: I667F

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	5	397	3.6e-58	PFAM
Pfam:NCD3G	442	495	2.2e-19	PFAM
Pfam:7tm_3	526	763	3.1e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg1	T	G	17: 31,283,428 (GRCm39)	S38A	probably benign	Het
Alkbh1	T	G	12: 87,478,197 (GRCm39)	D238A	probably damaging	Het
Arhgef17	A	T	7: 100,529,220 (GRCm39)	D1531E	probably benign	Het
Bltp1	A	T	3: 37,056,784 (GRCm39)	I3152F	probably damaging	Het
Cacng3	G	T	7: 122,271,180 (GRCm39)	G62W	probably damaging	Het
Cdh22	T	C	2: 164,958,093 (GRCm39)	I625V	probably benign	Het
Ces5a	T	C	8: 94,228,898 (GRCm39)	N444S	possibly damaging	Het
Chst13	A	T	6: 90,286,193 (GRCm39)	Y256*	probably null	Het
Clcn5	T	A	X: 7,044,613 (GRCm39)	H177L	probably benign	Het
Dars1	G	A	1: 128,341,427 (GRCm39)	R63C	probably damaging	Het
Dcun1d4	A	G	5: 73,677,572 (GRCm39)	S84G	probably benign	Het
Dcxr	T	C	11: 120,617,298 (GRCm39)	N82D	probably damaging	Het
Eef1a2	C	A	2: 180,790,527 (GRCm39)	K376N	possibly damaging	Het
Efhc1	G	A	1: 21,037,715 (GRCm39)	M297I	probably benign	Het
Etfb	G	T	7: 43,101,897 (GRCm39)	V64F	probably damaging	Het
Fam135b	A	C	15: 71,334,637 (GRCm39)	N852K	probably benign	Het
Gigyf2	T	C	1: 87,376,790 (GRCm39)		probably benign	Het
Gria4	T	C	9: 4,513,288 (GRCm39)	K274E	probably benign	Het
Irag1	A	T	7: 110,525,553 (GRCm39)	S200T	probably benign	Het
Itgae	A	G	11: 73,006,400 (GRCm39)	E356G	possibly damaging	Het
Med12l	C	T	3: 59,208,788 (GRCm39)	Q2139*	probably null	Het
Plxna4	A	G	6: 32,155,337 (GRCm39)	F1536L	possibly damaging	Het
Pramel19	A	T	4: 101,798,329 (GRCm39)	Q100L	probably damaging	Het
Rmnd5a	A	G	6: 71,370,119 (GRCm39)	I389T	probably damaging	Het
Rnf128	T	G	X: 138,511,985 (GRCm39)	V144G	probably damaging	Het
Rpgrip1	A	G	14: 52,378,109 (GRCm39)	T486A	possibly damaging	Het
Rps6kc1	T	C	1: 190,604,026 (GRCm39)	T199A	probably benign	Het
Skint5	T	A	4: 113,343,854 (GRCm39)	D1338V	unknown	Het
Slc35g2	A	T	9: 100,434,699 (GRCm39)	I324K	possibly damaging	Het
Slc4a5	G	A	6: 83,238,507 (GRCm39)	R225H	probably damaging	Het
Srgap3	A	T	6: 112,793,636 (GRCm39)	H113Q	probably damaging	Het
Stpg2	A	C	3: 139,014,970 (GRCm39)	K378N	possibly damaging	Het
Svep1	A	G	4: 58,066,422 (GRCm39)		probably benign	Het
Utp11	T	C	4: 124,573,521 (GRCm39)	K218E	probably damaging	Het
Wdfy3	A	G	5: 102,048,016 (GRCm39)	L1763P	probably damaging	Het
Wnt2	A	G	6: 17,989,959 (GRCm39)	Y313H	probably benign	Het
Zfp638	T	C	6: 83,923,229 (GRCm39)	S676P	probably benign	Het
Zfp747l1	A	G	7: 126,984,811 (GRCm39)		probably benign	Het

Other mutations in Vmn2r53

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01090:Vmn2r53	APN	7	12,334,835 (GRCm39)	missense	possibly damaging	0.70
IGL01997:Vmn2r53	APN	7	12,316,373 (GRCm39)	missense	possibly damaging	0.54
IGL02442:Vmn2r53	APN	7	12,315,656 (GRCm39)	missense	probably damaging	1.00
IGL02449:Vmn2r53	APN	7	12,316,288 (GRCm39)	missense	probably damaging	1.00
IGL02589:Vmn2r53	APN	7	12,315,872 (GRCm39)	missense	possibly damaging	0.93
IGL02986:Vmn2r53	APN	7	12,315,393 (GRCm39)	unclassified	probably benign
IGL03064:Vmn2r53	APN	7	12,334,937 (GRCm39)	missense	possibly damaging	0.89
IGL03093:Vmn2r53	APN	7	12,334,791 (GRCm39)	missense	probably benign	0.03
IGL03244:Vmn2r53	APN	7	12,340,435 (GRCm39)	missense	probably damaging	1.00
IGL03252:Vmn2r53	APN	7	12,340,318 (GRCm39)	missense	probably damaging	1.00
IGL03293:Vmn2r53	APN	7	12,332,349 (GRCm39)	missense	probably benign	0.34
R0109:Vmn2r53	UTSW	7	12,315,993 (GRCm39)	missense	probably damaging	1.00
R0453:Vmn2r53	UTSW	7	12,316,338 (GRCm39)	missense	probably damaging	1.00
R0735:Vmn2r53	UTSW	7	12,315,707 (GRCm39)	missense	probably benign
R0881:Vmn2r53	UTSW	7	12,334,859 (GRCm39)	missense	probably benign	0.01
R0894:Vmn2r53	UTSW	7	12,335,141 (GRCm39)	missense	probably benign	0.00
R0973:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0973:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0974:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0990:Vmn2r53	UTSW	7	12,315,429 (GRCm39)	missense	probably benign
R1102:Vmn2r53	UTSW	7	12,332,410 (GRCm39)	missense	possibly damaging	0.94
R1141:Vmn2r53	UTSW	7	12,334,673 (GRCm39)	missense	possibly damaging	0.54
R1263:Vmn2r53	UTSW	7	12,315,533 (GRCm39)	missense	probably benign	0.41
R1343:Vmn2r53	UTSW	7	12,318,701 (GRCm39)	missense	probably benign	0.08
R1750:Vmn2r53	UTSW	7	12,315,632 (GRCm39)	missense	probably damaging	1.00
R1836:Vmn2r53	UTSW	7	12,334,812 (GRCm39)	missense	probably damaging	1.00
R2035:Vmn2r53	UTSW	7	12,332,438 (GRCm39)	missense	possibly damaging	0.76
R2202:Vmn2r53	UTSW	7	12,335,366 (GRCm39)	missense	probably damaging	1.00
R3707:Vmn2r53	UTSW	7	12,315,981 (GRCm39)	missense	possibly damaging	0.95
R4372:Vmn2r53	UTSW	7	12,315,656 (GRCm39)	missense	probably damaging	0.98
R4615:Vmn2r53	UTSW	7	12,316,229 (GRCm39)	missense	probably damaging	1.00
R4655:Vmn2r53	UTSW	7	12,315,932 (GRCm39)	missense	possibly damaging	0.83
R4663:Vmn2r53	UTSW	7	12,334,901 (GRCm39)	missense	probably benign	0.21
R4708:Vmn2r53	UTSW	7	12,335,129 (GRCm39)	missense	probably benign
R4710:Vmn2r53	UTSW	7	12,335,129 (GRCm39)	missense	probably benign
R4774:Vmn2r53	UTSW	7	12,334,692 (GRCm39)	nonsense	probably null
R4859:Vmn2r53	UTSW	7	12,335,330 (GRCm39)	missense	probably damaging	1.00
R5061:Vmn2r53	UTSW	7	12,315,741 (GRCm39)	missense	probably benign	0.01
R5561:Vmn2r53	UTSW	7	12,335,347 (GRCm39)	missense	probably damaging	1.00
R5729:Vmn2r53	UTSW	7	12,334,733 (GRCm39)	missense	probably damaging	1.00
R6004:Vmn2r53	UTSW	7	12,316,328 (GRCm39)	missense	probably benign	0.12
R6083:Vmn2r53	UTSW	7	12,315,808 (GRCm39)	missense	probably benign
R6312:Vmn2r53	UTSW	7	12,332,566 (GRCm39)	critical splice acceptor site	probably null
R6700:Vmn2r53	UTSW	7	12,315,633 (GRCm39)	missense	probably damaging	0.96
R6783:Vmn2r53	UTSW	7	12,335,360 (GRCm39)	missense	probably damaging	1.00
R6852:Vmn2r53	UTSW	7	12,340,441 (GRCm39)	missense	probably damaging	0.99
R6889:Vmn2r53	UTSW	7	12,335,069 (GRCm39)	missense	probably benign	0.10
R6940:Vmn2r53	UTSW	7	12,316,343 (GRCm39)	missense	probably benign	0.19
R7100:Vmn2r53	UTSW	7	12,315,513 (GRCm39)	nonsense	probably null
R7174:Vmn2r53	UTSW	7	12,315,628 (GRCm39)	missense	probably benign	0.01
R7213:Vmn2r53	UTSW	7	12,334,983 (GRCm39)	missense	probably benign	0.17
R7276:Vmn2r53	UTSW	7	12,340,359 (GRCm39)	missense	probably damaging	0.99
R7515:Vmn2r53	UTSW	7	12,315,846 (GRCm39)	missense	probably benign	0.05
R7678:Vmn2r53	UTSW	7	12,332,425 (GRCm39)	missense	probably benign	0.04
R7714:Vmn2r53	UTSW	7	12,340,418 (GRCm39)	missense	probably damaging	1.00
R7843:Vmn2r53	UTSW	7	12,316,026 (GRCm39)	missense	probably damaging	1.00
R8208:Vmn2r53	UTSW	7	12,335,322 (GRCm39)	missense	probably damaging	1.00
R8211:Vmn2r53	UTSW	7	12,315,843 (GRCm39)	missense	probably benign	0.01
R8478:Vmn2r53	UTSW	7	12,340,281 (GRCm39)	missense	probably benign	0.01
R8853:Vmn2r53	UTSW	7	12,315,737 (GRCm39)	missense	probably damaging	1.00
R8924:Vmn2r53	UTSW	7	12,334,752 (GRCm39)	missense	probably benign	0.17
R8963:Vmn2r53	UTSW	7	12,315,926 (GRCm39)	missense	probably damaging	1.00
R9042:Vmn2r53	UTSW	7	12,315,435 (GRCm39)	missense	probably benign
R9076:Vmn2r53	UTSW	7	12,340,231 (GRCm39)	missense	probably damaging	1.00
R9407:Vmn2r53	UTSW	7	12,335,124 (GRCm39)	missense	probably damaging	0.99
R9690:Vmn2r53	UTSW	7	12,315,912 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r53	UTSW	7	12,335,231 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02