Incidental Mutation 'IGL03265:Zfp809'
ID415033
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp809
Ensembl Gene ENSMUSG00000057982
Gene Namezinc finger protein 809
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.125) question?
Stock #IGL03265
Quality Score
Status
Chromosome9
Chromosomal Location22225714-22243354 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 22243043 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 352 (Y352C)
Ref Sequence ENSEMBL: ENSMUSP00000072286 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072465] [ENSMUST00000086281] [ENSMUST00000213371] [ENSMUST00000215618] [ENSMUST00000215902]
Predicted Effect probably benign
Transcript: ENSMUST00000072465
AA Change: Y352C

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000072286
Gene: ENSMUSG00000057982
AA Change: Y352C

DomainStartEndE-ValueType
KRAB 4 64 7.56e-33 SMART
ZnF_C2H2 155 178 2.4e-3 SMART
ZnF_C2H2 184 206 4.79e-3 SMART
ZnF_C2H2 213 235 5.21e-4 SMART
ZnF_C2H2 241 263 2.57e-3 SMART
ZnF_C2H2 269 291 1.28e-3 SMART
ZnF_C2H2 297 319 1.1e-2 SMART
ZnF_C2H2 325 347 6.32e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000086281
SMART Domains Protein: ENSMUSP00000083462
Gene: ENSMUSG00000062794

DomainStartEndE-ValueType
KRAB 4 64 5.35e-33 SMART
ZnF_C2H2 228 250 5.59e-4 SMART
ZnF_C2H2 256 278 2.43e-4 SMART
ZnF_C2H2 284 306 1.69e-3 SMART
ZnF_C2H2 312 334 8.94e-3 SMART
ZnF_C2H2 340 362 8.47e-4 SMART
ZnF_C2H2 368 390 5.06e-2 SMART
ZnF_C2H2 396 418 7.9e-4 SMART
ZnF_C2H2 424 446 7.67e-2 SMART
ZnF_C2H2 452 474 1.64e-1 SMART
ZnF_C2H2 480 503 7.37e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000213371
Predicted Effect probably benign
Transcript: ENSMUST00000215618
Predicted Effect probably benign
Transcript: ENSMUST00000215902
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased expression of VL30-pro endogenous retroviruses (ERV) elements. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik T A 3: 37,047,991 D4777E probably benign Het
Abca8a C A 11: 110,053,103 M1113I probably benign Het
Acvr1b A G 15: 101,203,078 R374G probably damaging Het
Akr1a1 A G 4: 116,637,817 M286T probably benign Het
Anapc1 T C 2: 128,627,197 S1575G probably damaging Het
Apba2 A G 7: 64,695,323 D87G probably damaging Het
Arhgap21 A G 2: 20,849,628 F1641S probably benign Het
Atad2b T A 12: 5,024,628 H1062Q probably benign Het
Bivm A G 1: 44,141,845 R396G probably damaging Het
Bmi1 T A 2: 18,681,861 M17K possibly damaging Het
Bptf T C 11: 107,054,628 N2480S probably benign Het
Cacna2d3 T C 14: 28,952,286 E944G probably damaging Het
Ces2a C T 8: 104,737,443 H236Y possibly damaging Het
Dnah7a T C 1: 53,528,848 D1863G probably benign Het
Dnajc17 C A 2: 119,185,718 E91D probably benign Het
Dus2 C A 8: 106,033,791 probably benign Het
Epha6 T C 16: 60,060,231 probably benign Het
Erap1 A T 13: 74,664,127 T354S probably damaging Het
Fbxo11 T C 17: 87,992,831 H851R probably damaging Het
Gm20532 G A 2: 26,632,684 C90Y unknown Het
Gpr21 T C 2: 37,518,074 Y211H probably damaging Het
Hectd4 A G 5: 121,259,939 probably benign Het
Hephl1 G A 9: 15,060,959 T895I probably benign Het
Hey1 T C 3: 8,664,914 Y161C probably benign Het
Kdr A G 5: 75,960,773 Y526H probably damaging Het
Lpp A G 16: 24,761,987 Y151C probably damaging Het
Macc1 A G 12: 119,446,976 N493S probably benign Het
Olfr1022 T A 2: 85,869,150 M186K possibly damaging Het
Olfr1101 T A 2: 86,989,080 Y32F probably damaging Het
Olfr315 T C 11: 58,778,871 V248A probably damaging Het
Olfr605 C A 7: 103,442,448 R225L probably benign Het
Olfr786 A T 10: 129,436,925 T38S possibly damaging Het
Pcdhb21 A G 18: 37,515,153 D445G probably damaging Het
Prkra T C 2: 76,640,270 N123D probably benign Het
Slc25a33 A C 4: 149,762,436 L56R probably damaging Het
Usp36 A G 11: 118,264,809 V714A possibly damaging Het
Vmn1r174 T A 7: 23,754,473 L188* probably null Het
Vmn2r12 A G 5: 109,092,070 V209A probably benign Het
Other mutations in Zfp809
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02967:Zfp809 APN 9 22235102 missense probably damaging 1.00
IGL03117:Zfp809 APN 9 22238654 missense probably damaging 0.99
IGL03177:Zfp809 APN 9 22235051 missense probably damaging 0.99
IGL03250:Zfp809 APN 9 22238635 missense possibly damaging 0.91
R1080:Zfp809 UTSW 9 22235109 missense probably damaging 0.98
R1544:Zfp809 UTSW 9 22235099 missense probably damaging 1.00
R1875:Zfp809 UTSW 9 22238731 nonsense probably null
R2137:Zfp809 UTSW 9 22235138 missense probably benign 0.07
R2314:Zfp809 UTSW 9 22238680 missense possibly damaging 0.95
R2356:Zfp809 UTSW 9 22243040 missense probably benign 0.00
R5019:Zfp809 UTSW 9 22237702 missense probably benign 0.44
R5735:Zfp809 UTSW 9 22238931 nonsense probably null
R6483:Zfp809 UTSW 9 22236244 missense probably benign
R7106:Zfp809 UTSW 9 22236224 missense probably benign 0.04
Posted On2016-08-02