Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03265:Zfp809'

415033

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp809

Ensembl Gene

ENSMUSG00000057982

Gene Name

zinc finger protein 809

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.206) question?

Stock #

IGL03265

Quality Score

Status

Chromosome

Chromosomal Location

22137010-22154650 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 22154339 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 352 (Y352C)

Ref Sequence

ENSEMBL: ENSMUSP00000072286 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072465] [ENSMUST00000086281] [ENSMUST00000213371] [ENSMUST00000215618] [ENSMUST00000215902]

AlphaFold

G3X9G7

Predicted Effect

probably benign
Transcript: ENSMUST00000072465
AA Change: Y352C

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000072286
Gene: ENSMUSG00000057982
AA Change: Y352C

Domain	Start	End	E-Value	Type
KRAB	4	64	7.56e-33	SMART
ZnF_C2H2	155	178	2.4e-3	SMART
ZnF_C2H2	184	206	4.79e-3	SMART
ZnF_C2H2	213	235	5.21e-4	SMART
ZnF_C2H2	241	263	2.57e-3	SMART
ZnF_C2H2	269	291	1.28e-3	SMART
ZnF_C2H2	297	319	1.1e-2	SMART
ZnF_C2H2	325	347	6.32e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000086281

SMART Domains

Protein: ENSMUSP00000083462
Gene: ENSMUSG00000062794

Domain	Start	End	E-Value	Type
KRAB	4	64	5.35e-33	SMART
ZnF_C2H2	228	250	5.59e-4	SMART
ZnF_C2H2	256	278	2.43e-4	SMART
ZnF_C2H2	284	306	1.69e-3	SMART
ZnF_C2H2	312	334	8.94e-3	SMART
ZnF_C2H2	340	362	8.47e-4	SMART
ZnF_C2H2	368	390	5.06e-2	SMART
ZnF_C2H2	396	418	7.9e-4	SMART
ZnF_C2H2	424	446	7.67e-2	SMART
ZnF_C2H2	452	474	1.64e-1	SMART
ZnF_C2H2	480	503	7.37e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000213371

Predicted Effect

probably benign
Transcript: ENSMUST00000215618

Predicted Effect

probably benign
Transcript: ENSMUST00000215902

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased expression of VL30-pro endogenous retroviruses (ERV) elements. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8a	C	A	11: 109,943,929 (GRCm39)	M1113I	probably benign	Het
Acvr1b	A	G	15: 101,100,959 (GRCm39)	R374G	probably damaging	Het
Akr1a1	A	G	4: 116,495,014 (GRCm39)	M286T	probably benign	Het
Anapc1	T	C	2: 128,469,117 (GRCm39)	S1575G	probably damaging	Het
Apba2	A	G	7: 64,345,071 (GRCm39)	D87G	probably damaging	Het
Arhgap21	A	G	2: 20,854,439 (GRCm39)	F1641S	probably benign	Het
Atad2b	T	A	12: 5,074,628 (GRCm39)	H1062Q	probably benign	Het
Bivm	A	G	1: 44,181,005 (GRCm39)	R396G	probably damaging	Het
Bltp1	T	A	3: 37,102,140 (GRCm39)	D4777E	probably benign	Het
Bmi1	T	A	2: 18,686,672 (GRCm39)	M17K	possibly damaging	Het
Bptf	T	C	11: 106,945,454 (GRCm39)	N2480S	probably benign	Het
Cacna2d3	T	C	14: 28,674,243 (GRCm39)	E944G	probably damaging	Het
Ces2a	C	T	8: 105,464,075 (GRCm39)	H236Y	possibly damaging	Het
Dnah7a	T	C	1: 53,568,007 (GRCm39)	D1863G	probably benign	Het
Dnajc17	C	A	2: 119,016,199 (GRCm39)	E91D	probably benign	Het
Dus2	C	A	8: 106,760,423 (GRCm39)		probably benign	Het
Epha6	T	C	16: 59,880,594 (GRCm39)		probably benign	Het
Erap1	A	T	13: 74,812,246 (GRCm39)	T354S	probably damaging	Het
Fbxo11	T	C	17: 88,300,259 (GRCm39)	H851R	probably damaging	Het
Gm20532	G	A	2: 26,522,696 (GRCm39)	C90Y	unknown	Het
Gpr21	T	C	2: 37,408,086 (GRCm39)	Y211H	probably damaging	Het
Hectd4	A	G	5: 121,398,002 (GRCm39)		probably benign	Het
Hephl1	G	A	9: 14,972,255 (GRCm39)	T895I	probably benign	Het
Hey1	T	C	3: 8,729,974 (GRCm39)	Y161C	probably benign	Het
Kdr	A	G	5: 76,121,433 (GRCm39)	Y526H	probably damaging	Het
Lpp	A	G	16: 24,580,737 (GRCm39)	Y151C	probably damaging	Het
Macc1	A	G	12: 119,410,711 (GRCm39)	N493S	probably benign	Het
Or2t45	T	C	11: 58,669,697 (GRCm39)	V248A	probably damaging	Het
Or52s6	C	A	7: 103,091,655 (GRCm39)	R225L	probably benign	Het
Or5m10b	T	A	2: 85,699,494 (GRCm39)	M186K	possibly damaging	Het
Or5t16	T	A	2: 86,819,424 (GRCm39)	Y32F	probably damaging	Het
Or6c1b	A	T	10: 129,272,794 (GRCm39)	T38S	possibly damaging	Het
Pcdhb21	A	G	18: 37,648,206 (GRCm39)	D445G	probably damaging	Het
Prkra	T	C	2: 76,470,614 (GRCm39)	N123D	probably benign	Het
Slc25a33	A	C	4: 149,846,893 (GRCm39)	L56R	probably damaging	Het
Usp36	A	G	11: 118,155,635 (GRCm39)	V714A	possibly damaging	Het
Vmn1r174	T	A	7: 23,453,898 (GRCm39)	L188*	probably null	Het
Vmn2r12	A	G	5: 109,239,936 (GRCm39)	V209A	probably benign	Het

Other mutations in Zfp809

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02967:Zfp809	APN	9	22,146,398 (GRCm39)	missense	probably damaging	1.00
IGL03117:Zfp809	APN	9	22,149,950 (GRCm39)	missense	probably damaging	0.99
IGL03177:Zfp809	APN	9	22,146,347 (GRCm39)	missense	probably damaging	0.99
IGL03250:Zfp809	APN	9	22,149,931 (GRCm39)	missense	possibly damaging	0.91
R1080:Zfp809	UTSW	9	22,146,405 (GRCm39)	missense	probably damaging	0.98
R1544:Zfp809	UTSW	9	22,146,395 (GRCm39)	missense	probably damaging	1.00
R1875:Zfp809	UTSW	9	22,150,027 (GRCm39)	nonsense	probably null
R2137:Zfp809	UTSW	9	22,146,434 (GRCm39)	missense	probably benign	0.07
R2314:Zfp809	UTSW	9	22,149,976 (GRCm39)	missense	possibly damaging	0.95
R2356:Zfp809	UTSW	9	22,154,336 (GRCm39)	missense	probably benign	0.00
R5019:Zfp809	UTSW	9	22,148,998 (GRCm39)	missense	probably benign	0.44
R5735:Zfp809	UTSW	9	22,150,227 (GRCm39)	nonsense	probably null
R6483:Zfp809	UTSW	9	22,147,540 (GRCm39)	missense	probably benign
R7106:Zfp809	UTSW	9	22,147,520 (GRCm39)	missense	probably benign	0.04
R8969:Zfp809	UTSW	9	22,137,130 (GRCm39)	critical splice donor site	probably null
R9364:Zfp809	UTSW	9	22,150,394 (GRCm39)	missense	probably damaging	0.99
R9600:Zfp809	UTSW	9	22,150,384 (GRCm39)	missense	possibly damaging	0.69
R9666:Zfp809	UTSW	9	22,149,863 (GRCm39)	missense	probably benign	0.07
R9700:Zfp809	UTSW	9	22,154,470 (GRCm39)	missense	unknown

Posted On

2016-08-02