Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03265:Gpr21'

415042

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr21

Ensembl Gene

ENSMUSG00000053164

Gene Name

G protein-coupled receptor 21

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

IGL03265

Quality Score

Status

Chromosome

Chromosomal Location

37516332-37520603 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 37518074 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 211 (Y211H)

Ref Sequence

ENSEMBL: ENSMUSP00000066449 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061179] [ENSMUST00000065441] [ENSMUST00000066055] [ENSMUST00000112920] [ENSMUST00000183690]

Predicted Effect

probably benign
Transcript: ENSMUST00000061179

SMART Domains

Protein: ENSMUSP00000061624
Gene: ENSMUSG00000035437

Domain	Start	End	E-Value	Type
low complexity region	6	22	N/A	INTRINSIC
PTB	138	271	2.99e-30	SMART
Pfam:DUF3694	301	433	1.1e-38	PFAM
low complexity region	449	460	N/A	INTRINSIC
low complexity region	473	481	N/A	INTRINSIC
low complexity region	502	516	N/A	INTRINSIC
TBC	558	770	9.27e-74	SMART
Blast:TBC	803	880	9e-33	BLAST
coiled coil region	986	1038	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000065441
AA Change: Y211H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000066449
Gene: ENSMUSG00000053164
AA Change: Y211H

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	34	239	4.8e-7	PFAM
Pfam:7tm_4	34	307	3.3e-9	PFAM
Pfam:7tm_1	45	304	9.4e-39	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000066055

SMART Domains

Protein: ENSMUSP00000068835
Gene: ENSMUSG00000035437

Domain	Start	End	E-Value	Type
low complexity region	6	22	N/A	INTRINSIC
PTB	138	271	2.99e-30	SMART
Pfam:DUF3694	301	433	7.1e-39	PFAM
low complexity region	449	460	N/A	INTRINSIC
low complexity region	473	481	N/A	INTRINSIC
low complexity region	502	516	N/A	INTRINSIC
TBC	558	770	9.27e-74	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000112920

SMART Domains

Protein: ENSMUSP00000108542
Gene: ENSMUSG00000035437

Domain	Start	End	E-Value	Type
low complexity region	6	22	N/A	INTRINSIC
PTB	138	271	2.99e-30	SMART
Pfam:DUF3694	301	432	1.6e-35	PFAM
low complexity region	449	460	N/A	INTRINSIC
low complexity region	473	481	N/A	INTRINSIC
low complexity region	502	516	N/A	INTRINSIC
TBC	558	770	9.27e-74	SMART
Blast:TBC	803	880	9e-33	BLAST
coiled coil region	986	1038	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159092

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159737

Predicted Effect

probably benign
Transcript: ENSMUST00000183690

SMART Domains

Protein: ENSMUSP00000139145
Gene: ENSMUSG00000026915

Domain	Start	End	E-Value	Type
DZF	81	334	2.45e-168	SMART
DSRM	388	452	3.11e-16	SMART
low complexity region	474	497	N/A	INTRINSIC
DSRM	511	575	1.2e-22	SMART
low complexity region	578	593	N/A	INTRINSIC
low complexity region	608	618	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G-protein-coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. The encoded protein activates a Gq signal transduction pathway which mobilizes calcium. [provided by RefSeq, Nov 2012]
PHENOTYPE: Mice homozygous for a targeted allele exhibit improved glucose tolerance, insulin response and resistance to diet-induced obesity. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	A	3: 37,047,991	D4777E	probably benign	Het
Abca8a	C	A	11: 110,053,103	M1113I	probably benign	Het
Acvr1b	A	G	15: 101,203,078	R374G	probably damaging	Het
Akr1a1	A	G	4: 116,637,817	M286T	probably benign	Het
Anapc1	T	C	2: 128,627,197	S1575G	probably damaging	Het
Apba2	A	G	7: 64,695,323	D87G	probably damaging	Het
Arhgap21	A	G	2: 20,849,628	F1641S	probably benign	Het
Atad2b	T	A	12: 5,024,628	H1062Q	probably benign	Het
Bivm	A	G	1: 44,141,845	R396G	probably damaging	Het
Bmi1	T	A	2: 18,681,861	M17K	possibly damaging	Het
Bptf	T	C	11: 107,054,628	N2480S	probably benign	Het
Cacna2d3	T	C	14: 28,952,286	E944G	probably damaging	Het
Ces2a	C	T	8: 104,737,443	H236Y	possibly damaging	Het
Dnah7a	T	C	1: 53,528,848	D1863G	probably benign	Het
Dnajc17	C	A	2: 119,185,718	E91D	probably benign	Het
Dus2	C	A	8: 106,033,791		probably benign	Het
Epha6	T	C	16: 60,060,231		probably benign	Het
Erap1	A	T	13: 74,664,127	T354S	probably damaging	Het
Fbxo11	T	C	17: 87,992,831	H851R	probably damaging	Het
Gm20532	G	A	2: 26,632,684	C90Y	unknown	Het
Hectd4	A	G	5: 121,259,939		probably benign	Het
Hephl1	G	A	9: 15,060,959	T895I	probably benign	Het
Hey1	T	C	3: 8,664,914	Y161C	probably benign	Het
Kdr	A	G	5: 75,960,773	Y526H	probably damaging	Het
Lpp	A	G	16: 24,761,987	Y151C	probably damaging	Het
Macc1	A	G	12: 119,446,976	N493S	probably benign	Het
Olfr1022	T	A	2: 85,869,150	M186K	possibly damaging	Het
Olfr1101	T	A	2: 86,989,080	Y32F	probably damaging	Het
Olfr315	T	C	11: 58,778,871	V248A	probably damaging	Het
Olfr605	C	A	7: 103,442,448	R225L	probably benign	Het
Olfr786	A	T	10: 129,436,925	T38S	possibly damaging	Het
Pcdhb21	A	G	18: 37,515,153	D445G	probably damaging	Het
Prkra	T	C	2: 76,640,270	N123D	probably benign	Het
Slc25a33	A	C	4: 149,762,436	L56R	probably damaging	Het
Usp36	A	G	11: 118,264,809	V714A	possibly damaging	Het
Vmn1r174	T	A	7: 23,754,473	L188*	probably null	Het
Vmn2r12	A	G	5: 109,092,070	V209A	probably benign	Het
Zfp809	A	G	9: 22,243,043	Y352C	probably benign	Het

Other mutations in Gpr21

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01510:Gpr21	APN	2	37518421	nonsense	probably null
IGL01877:Gpr21	APN	2	37518081	missense	probably benign	0.13
lasco	UTSW	2	37517544	missense	probably damaging	0.99
R0573:Gpr21	UTSW	2	37517544	missense	probably damaging	0.99
R1548:Gpr21	UTSW	2	37518072	missense	probably damaging	1.00
R1781:Gpr21	UTSW	2	37517538	missense	probably benign	0.00
R1922:Gpr21	UTSW	2	37518338	missense	probably damaging	0.99
R2011:Gpr21	UTSW	2	37517535	missense	probably damaging	1.00
R2144:Gpr21	UTSW	2	37518231	missense	probably benign	0.02
R3818:Gpr21	UTSW	2	37518312	missense	probably damaging	1.00
R3978:Gpr21	UTSW	2	37517850	missense	probably benign	0.23
R4412:Gpr21	UTSW	2	37517432	intron	probably benign
R4466:Gpr21	UTSW	2	37517558	missense	probably benign	0.10
R6807:Gpr21	UTSW	2	37517962	nonsense	probably null

Posted On

2016-08-02