Incidental Mutation 'IGL03266:Trbv3'
ID 415079
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trbv3
Ensembl Gene ENSMUSG00000076463
Gene Name T cell receptor beta, variable 3
Synonyms Gm2426, Tcrb-V16
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL03266
Quality Score
Status
Chromosome 6
Chromosomal Location 41025328-41025758 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 41025658 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 83 (Q83K)
Ref Sequence ENSEMBL: ENSMUSP00000100080 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103263] [ENSMUST00000103264]
AlphaFold A0A0A6YYE2
Predicted Effect probably benign
Transcript: ENSMUST00000103263
SMART Domains Protein: ENSMUSP00000100079
Gene: ENSMUSG00000076462

DomainStartEndE-ValueType
Pfam:V-set 22 114 2.8e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000103264
AA Change: Q83K

PolyPhen 2 Score 0.255 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000100080
Gene: ENSMUSG00000076463
AA Change: Q83K

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IG 27 117 1.9e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb1 A T 6: 88,815,916 (GRCm39) V185E probably damaging Het
Acly T C 11: 100,374,578 (GRCm39) E815G probably damaging Het
Actr10 T G 12: 71,003,440 (GRCm39) S261A probably benign Het
Als2cl T C 9: 110,719,924 (GRCm39) V504A possibly damaging Het
Btla T C 16: 45,059,638 (GRCm39) I114T probably damaging Het
Cacna2d3 T A 14: 29,022,705 (GRCm39) I348L probably benign Het
Chst15 T A 7: 131,871,805 (GRCm39) I159F probably damaging Het
Creld1 T A 6: 113,466,558 (GRCm39) H208Q probably benign Het
Fap C T 2: 62,367,366 (GRCm39) V334I probably benign Het
Fat2 C T 11: 55,174,855 (GRCm39) V1953M possibly damaging Het
Fgfr3 G A 5: 33,891,709 (GRCm39) A595T probably damaging Het
Gm8122 T A 14: 43,090,116 (GRCm39) M125L unknown Het
Itprid2 G A 2: 79,472,534 (GRCm39) probably null Het
Klk1b1 T G 7: 43,619,900 (GRCm39) L153R probably benign Het
Lrig3 T A 10: 125,849,151 (GRCm39) M957K probably benign Het
Mc3r C T 2: 172,091,189 (GRCm39) A137V probably benign Het
Met T A 6: 17,540,537 (GRCm39) L821Q possibly damaging Het
Mrps17 T C 5: 129,793,806 (GRCm39) probably benign Het
Myh2 A G 11: 67,067,150 (GRCm39) T202A probably benign Het
Nae1 T C 8: 105,239,828 (GRCm39) probably benign Het
Pkhd1l1 T A 15: 44,402,348 (GRCm39) I2240N probably damaging Het
Stat6 T C 10: 127,493,024 (GRCm39) L552P possibly damaging Het
Uaca A T 9: 60,770,689 (GRCm39) D344V probably damaging Het
Ube2q2l T C 6: 136,377,921 (GRCm39) E303G probably damaging Het
Uggt1 A T 1: 36,189,129 (GRCm39) D1452E probably damaging Het
Vwf T C 6: 125,655,040 (GRCm39) probably benign Het
Other mutations in Trbv3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02524:Trbv3 APN 6 41,025,599 (GRCm39) missense possibly damaging 0.64
IGL02727:Trbv3 APN 6 41,025,576 (GRCm39) missense probably benign 0.08
R5941:Trbv3 UTSW 6 41,025,335 (GRCm39) missense probably benign 0.00
R6630:Trbv3 UTSW 6 41,025,506 (GRCm39) missense possibly damaging 0.79
R7409:Trbv3 UTSW 6 41,025,524 (GRCm39) missense probably damaging 1.00
R7989:Trbv3 UTSW 6 41,025,576 (GRCm39) missense probably benign 0.08
R9463:Trbv3 UTSW 6 41,025,530 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02