Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03267:Wfdc16'

415111

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wfdc16

Ensembl Gene

ENSMUSG00000070530

Gene Name

WAP four-disulfide core domain 16

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL03267

Quality Score

Status

Chromosome

Chromosomal Location

164476627-164480716 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 164480462 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 11 (V11A)

Ref Sequence

ENSEMBL: ENSMUSP00000104960 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109336]

AlphaFold

A2A5H4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000109336
AA Change: V11A

PolyPhen 2 Score 0.455 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000104960
Gene: ENSMUSG00000070530
AA Change: V11A

Domain	Start	End	E-Value	Type
transmembrane domain	10	28	N/A	INTRINSIC
WAP	51	91	3.41e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000121070

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acad10	C	T	5: 121,775,412 (GRCm39)	R430Q	probably benign	Het
Arfgef3	T	A	10: 18,467,630 (GRCm39)	I1857F	probably damaging	Het
Baat	T	A	4: 49,490,050 (GRCm39)	M345L	probably benign	Het
Babam1	T	G	8: 71,855,708 (GRCm39)		probably null	Het
Bbs7	A	G	3: 36,627,654 (GRCm39)	F711S	probably damaging	Het
Btrc	A	G	19: 45,507,262 (GRCm39)	E458G	probably damaging	Het
Car6	T	C	4: 150,280,503 (GRCm39)		probably benign	Het
Celsr3	T	C	9: 108,713,724 (GRCm39)		probably benign	Het
Csn2	A	G	5: 87,845,930 (GRCm39)	V3A	possibly damaging	Het
Ddc	T	C	11: 11,826,303 (GRCm39)	Y86C	probably damaging	Het
Dennd1b	A	T	1: 138,990,599 (GRCm39)	R188*	probably null	Het
Dnah1	C	A	14: 31,008,545 (GRCm39)	A2046S	probably benign	Het
Duxf4	T	C	10: 58,071,609 (GRCm39)	T202A	probably damaging	Het
Eif2b4	A	T	5: 31,350,003 (GRCm39)	S20T	possibly damaging	Het
Etl4	T	A	2: 20,789,993 (GRCm39)	C916*	probably null	Het
Fam78a	T	C	2: 31,959,679 (GRCm39)	I144V	probably benign	Het
Fcho1	A	G	8: 72,164,943 (GRCm39)		probably benign	Het
Il9r	T	A	11: 32,141,778 (GRCm39)	H320L	possibly damaging	Het
Kntc1	C	T	5: 123,896,543 (GRCm39)	T135M	probably damaging	Het
Lca5l	T	A	16: 95,960,983 (GRCm39)	Q498L	probably benign	Het
Map4k3	T	C	17: 80,971,457 (GRCm39)	H70R	probably damaging	Het
Mrps26	A	G	2: 130,406,856 (GRCm39)		probably null	Het
Or1j20	G	T	2: 36,760,513 (GRCm39)	A312S	probably benign	Het
Or4k5	A	G	14: 50,386,304 (GRCm39)	V9A	probably damaging	Het
Or8j3b	A	T	2: 86,204,978 (GRCm39)	Y259*	probably null	Het
Pik3cg	C	A	12: 32,255,307 (GRCm39)	G227C	possibly damaging	Het
Ptprn2	C	T	12: 116,839,964 (GRCm39)	Q496*	probably null	Het
Rif1	T	G	2: 51,967,000 (GRCm39)	N96K	possibly damaging	Het
Rreb1	A	C	13: 38,116,169 (GRCm39)	D1176A	probably benign	Het
Slc22a30	A	G	19: 8,315,322 (GRCm39)	I436T	probably benign	Het
Slc51a	G	A	16: 32,297,568 (GRCm39)	R110C	probably damaging	Het
Spata31e5	G	A	1: 28,816,202 (GRCm39)	T610I	probably damaging	Het
Stab1	A	G	14: 30,864,686 (GRCm39)	C1950R	probably damaging	Het
Tns2	T	C	15: 102,013,813 (GRCm39)		probably null	Het
Ttf2	G	A	3: 100,852,120 (GRCm39)	R1009*	probably null	Het
Zfp367	A	G	13: 64,292,097 (GRCm39)		probably benign	Het
Zfp420	G	A	7: 29,574,908 (GRCm39)	R376H	probably damaging	Het

Other mutations in Wfdc16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01080:Wfdc16	APN	2	164,480,406 (GRCm39)	missense	probably damaging	0.97
IGL02627:Wfdc16	APN	2	164,480,383 (GRCm39)	missense	possibly damaging	0.46
R0541:Wfdc16	UTSW	2	164,477,773 (GRCm39)	missense	possibly damaging	0.73
R1171:Wfdc16	UTSW	2	164,480,403 (GRCm39)	missense	possibly damaging	0.66
R1579:Wfdc16	UTSW	2	164,477,843 (GRCm39)	missense	possibly damaging	0.46
R1598:Wfdc16	UTSW	2	164,477,350 (GRCm39)	missense	probably benign	0.00
R7584:Wfdc16	UTSW	2	164,480,547 (GRCm39)	splice site	probably null
R7780:Wfdc16	UTSW	2	164,477,785 (GRCm39)	missense	probably benign	0.04
R8705:Wfdc16	UTSW	2	164,480,395 (GRCm39)	missense	possibly damaging	0.66
R8854:Wfdc16	UTSW	2	164,480,486 (GRCm39)	missense	probably benign

Posted On

2016-08-02