Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03267:Duxf4'

415112

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Duxf4

Ensembl Gene

ENSMUSG00000075045

Gene Name

double homeobox family member 4

Synonyms

Gm4981, Duxf4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

IGL03267

Quality Score

Status

Chromosome

Chromosomal Location

58070670-58072482 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 58071609 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 202 (T202A)

Ref Sequence

ENSEMBL: ENSMUSP00000097314 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099726] [ENSMUST00000174056] [ENSMUST00000176875]

AlphaFold

Q3ULJ8

Predicted Effect

probably damaging
Transcript: ENSMUST00000099726
AA Change: T202A

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000097314
Gene: ENSMUSG00000075045
AA Change: T202A

Domain	Start	End	E-Value	Type
HOX	5	67	1.13e-11	SMART
internal_repeat_1	86	173	1.27e-12	PROSPERO
internal_repeat_1	177	264	1.27e-12	PROSPERO

Predicted Effect

probably benign
Transcript: ENSMUST00000174056

SMART Domains

Protein: ENSMUSP00000133909
Gene: ENSMUSG00000075046

Domain	Start	End	E-Value	Type
HOX	2	58	9.45e-5	SMART
HOX	90	152	8.78e-23	SMART
internal_repeat_1	172	207	1.03e-13	PROSPERO
low complexity region	236	247	N/A	INTRINSIC
internal_repeat_1	264	299	1.03e-13	PROSPERO
low complexity region	303	323	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176240

Predicted Effect

probably benign
Transcript: ENSMUST00000176875

SMART Domains

Protein: ENSMUSP00000145004
Gene: ENSMUSG00000075046

Domain	Start	End	E-Value	Type
HOX	18	80	1.7e-13	SMART
HOX	112	174	1.6e-23	SMART
internal_repeat_1	194	371	2.07e-48	PROSPERO
low complexity region	416	436	N/A	INTRINSIC
low complexity region	441	456	N/A	INTRINSIC
internal_repeat_1	468	645	2.07e-48	PROSPERO

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acad10	C	T	5: 121,775,412 (GRCm39)	R430Q	probably benign	Het
Arfgef3	T	A	10: 18,467,630 (GRCm39)	I1857F	probably damaging	Het
Baat	T	A	4: 49,490,050 (GRCm39)	M345L	probably benign	Het
Babam1	T	G	8: 71,855,708 (GRCm39)		probably null	Het
Bbs7	A	G	3: 36,627,654 (GRCm39)	F711S	probably damaging	Het
Btrc	A	G	19: 45,507,262 (GRCm39)	E458G	probably damaging	Het
Car6	T	C	4: 150,280,503 (GRCm39)		probably benign	Het
Celsr3	T	C	9: 108,713,724 (GRCm39)		probably benign	Het
Csn2	A	G	5: 87,845,930 (GRCm39)	V3A	possibly damaging	Het
Ddc	T	C	11: 11,826,303 (GRCm39)	Y86C	probably damaging	Het
Dennd1b	A	T	1: 138,990,599 (GRCm39)	R188*	probably null	Het
Dnah1	C	A	14: 31,008,545 (GRCm39)	A2046S	probably benign	Het
Eif2b4	A	T	5: 31,350,003 (GRCm39)	S20T	possibly damaging	Het
Etl4	T	A	2: 20,789,993 (GRCm39)	C916*	probably null	Het
Fam78a	T	C	2: 31,959,679 (GRCm39)	I144V	probably benign	Het
Fcho1	A	G	8: 72,164,943 (GRCm39)		probably benign	Het
Il9r	T	A	11: 32,141,778 (GRCm39)	H320L	possibly damaging	Het
Kntc1	C	T	5: 123,896,543 (GRCm39)	T135M	probably damaging	Het
Lca5l	T	A	16: 95,960,983 (GRCm39)	Q498L	probably benign	Het
Map4k3	T	C	17: 80,971,457 (GRCm39)	H70R	probably damaging	Het
Mrps26	A	G	2: 130,406,856 (GRCm39)		probably null	Het
Or1j20	G	T	2: 36,760,513 (GRCm39)	A312S	probably benign	Het
Or4k5	A	G	14: 50,386,304 (GRCm39)	V9A	probably damaging	Het
Or8j3b	A	T	2: 86,204,978 (GRCm39)	Y259*	probably null	Het
Pik3cg	C	A	12: 32,255,307 (GRCm39)	G227C	possibly damaging	Het
Ptprn2	C	T	12: 116,839,964 (GRCm39)	Q496*	probably null	Het
Rif1	T	G	2: 51,967,000 (GRCm39)	N96K	possibly damaging	Het
Rreb1	A	C	13: 38,116,169 (GRCm39)	D1176A	probably benign	Het
Slc22a30	A	G	19: 8,315,322 (GRCm39)	I436T	probably benign	Het
Slc51a	G	A	16: 32,297,568 (GRCm39)	R110C	probably damaging	Het
Spata31e5	G	A	1: 28,816,202 (GRCm39)	T610I	probably damaging	Het
Stab1	A	G	14: 30,864,686 (GRCm39)	C1950R	probably damaging	Het
Tns2	T	C	15: 102,013,813 (GRCm39)		probably null	Het
Ttf2	G	A	3: 100,852,120 (GRCm39)	R1009*	probably null	Het
Wfdc16	A	G	2: 164,480,462 (GRCm39)	V11A	possibly damaging	Het
Zfp367	A	G	13: 64,292,097 (GRCm39)		probably benign	Het
Zfp420	G	A	7: 29,574,908 (GRCm39)	R376H	probably damaging	Het

Other mutations in Duxf4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01720:Duxf4	APN	10	58,072,211 (GRCm39)	start codon destroyed	probably null	0.06
R0021:Duxf4	UTSW	10	58,071,385 (GRCm39)	missense	probably benign
R0582:Duxf4	UTSW	10	58,071,508 (GRCm39)	missense	probably benign	0.04
R1857:Duxf4	UTSW	10	58,071,602 (GRCm39)	missense	probably benign	0.00
R1858:Duxf4	UTSW	10	58,071,602 (GRCm39)	missense	probably benign	0.00
R1859:Duxf4	UTSW	10	58,071,602 (GRCm39)	missense	probably benign	0.00
R1984:Duxf4	UTSW	10	58,071,785 (GRCm39)	missense	possibly damaging	0.53
R2115:Duxf4	UTSW	10	58,072,073 (GRCm39)	missense	possibly damaging	0.92
R2197:Duxf4	UTSW	10	58,072,158 (GRCm39)	missense	possibly damaging	0.71
R3014:Duxf4	UTSW	10	58,071,356 (GRCm39)	missense	possibly damaging	0.86
R3412:Duxf4	UTSW	10	58,072,175 (GRCm39)	missense	possibly damaging	0.93
R3983:Duxf4	UTSW	10	58,071,623 (GRCm39)	missense	possibly damaging	0.95
R4500:Duxf4	UTSW	10	58,071,528 (GRCm39)	missense	possibly damaging	0.70
R4939:Duxf4	UTSW	10	58,071,425 (GRCm39)	missense	probably benign	0.33
R5460:Duxf4	UTSW	10	58,071,717 (GRCm39)	missense	possibly damaging	0.94
R6228:Duxf4	UTSW	10	58,071,344 (GRCm39)	missense	probably benign	0.02
R8282:Duxf4	UTSW	10	58,072,148 (GRCm39)	missense	possibly damaging	0.71
R9051:Duxf4	UTSW	10	58,071,711 (GRCm39)	missense	probably damaging	1.00
R9571:Duxf4	UTSW	10	58,071,378 (GRCm39)	missense	possibly damaging	0.86
Z1088:Duxf4	UTSW	10	58,071,733 (GRCm39)	missense	probably damaging	0.97

Posted On

2016-08-02