Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03269:Ceacam3'

415195

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ceacam3

Ensembl Gene

ENSMUSG00000053228

Gene Name

CEA cell adhesion molecule 3

Synonyms

EG384557, cea12, Psg24

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03269

Quality Score

Status

Chromosome

Chromosomal Location

16884207-16898178 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 16895767 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 579 (L579Q)

Ref Sequence

ENSEMBL: ENSMUSP00000104131 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108491]

AlphaFold

E9Q6J4

Predicted Effect

probably damaging
Transcript: ENSMUST00000108491
AA Change: L579Q

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000104131
Gene: ENSMUSG00000053228
AA Change: L579Q

Domain	Start	End	E-Value	Type
IG	40	141	2.83e-3	SMART
IG	160	261	6.31e-1	SMART
IG	280	379	8.01e-3	SMART
IG	398	497	2.08e-1	SMART
IG	514	613	1.26e0	SMART
IGc2	631	695	7.64e-9	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl2	T	A	2: 26,998,367 (GRCm39)	C930*	probably null	Het
Ankar	A	T	1: 72,704,360 (GRCm39)	V854E	probably damaging	Het
Clip2	G	T	5: 134,545,748 (GRCm39)	H314Q	probably damaging	Het
Fbxo28	A	G	1: 182,144,583 (GRCm39)	V327A	possibly damaging	Het
Gdap1	T	A	1: 17,231,729 (GRCm39)	F358Y	probably benign	Het
Ift70a2	T	C	2: 75,808,479 (GRCm39)	D11G	possibly damaging	Het
Ighv1-18	T	C	12: 114,646,466 (GRCm39)	Y46C	probably damaging	Het
Il1rl2	T	A	1: 40,404,472 (GRCm39)	F531Y	probably damaging	Het
Irf6	A	G	1: 192,844,906 (GRCm39)		probably benign	Het
Ncoa6	T	C	2: 155,248,409 (GRCm39)	T1632A	probably damaging	Het
Odad3	A	G	9: 21,909,339 (GRCm39)		probably null	Het
Or4l1	T	A	14: 50,166,165 (GRCm39)	T279S	probably damaging	Het
Or5b3	T	A	19: 13,388,792 (GRCm39)	N286K	probably damaging	Het
Or8b43	A	G	9: 38,360,197 (GRCm39)	T10A	probably benign	Het
Osgepl1	C	A	1: 53,360,271 (GRCm39)	Y332*	probably null	Het
Pibf1	G	A	14: 99,425,171 (GRCm39)	A553T	probably damaging	Het
Prpf38b	A	G	3: 108,812,557 (GRCm39)	F219L	probably benign	Het
Pwp1	C	A	10: 85,718,768 (GRCm39)	Q312K	probably damaging	Het
Rnf17	T	C	14: 56,665,403 (GRCm39)	V185A	possibly damaging	Het
Serpina3k	T	C	12: 104,306,780 (GRCm39)	I4T	possibly damaging	Het
Slc33a1	A	G	3: 63,871,178 (GRCm39)	V145A	probably damaging	Het
Slco3a1	T	C	7: 73,968,280 (GRCm39)	D480G	possibly damaging	Het
Tdpoz4	G	A	3: 93,704,144 (GRCm39)	C147Y	probably damaging	Het
Tlr4	C	A	4: 66,759,033 (GRCm39)	P609T	probably damaging	Het
Trgv4	T	A	13: 19,369,622 (GRCm39)	I122K	probably damaging	Het
Unc79	A	G	12: 103,054,936 (GRCm39)	K927E	probably damaging	Het
Vmn1r71	G	A	7: 10,482,571 (GRCm39)	T39I	possibly damaging	Het
Vmn2r9	A	G	5: 108,995,820 (GRCm39)	L276P	probably damaging	Het
Zfp335	C	A	2: 164,742,274 (GRCm39)	R570L	probably damaging	Het

Other mutations in Ceacam3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01161:Ceacam3	APN	7	16,885,782 (GRCm39)	missense	probably benign	0.03
IGL01510:Ceacam3	APN	7	16,893,767 (GRCm39)	missense	probably benign	0.00
IGL01830:Ceacam3	APN	7	16,888,925 (GRCm39)	missense	possibly damaging	0.79
IGL02155:Ceacam3	APN	7	16,896,906 (GRCm39)	missense	possibly damaging	0.58
IGL02281:Ceacam3	APN	7	16,895,656 (GRCm39)	missense	probably benign	0.43
IGL02301:Ceacam3	APN	7	16,897,026 (GRCm39)	missense	probably damaging	1.00
IGL02320:Ceacam3	APN	7	16,895,865 (GRCm39)	missense	probably benign	0.43
IGL02514:Ceacam3	APN	7	16,896,906 (GRCm39)	missense	possibly damaging	0.58
IGL02929:Ceacam3	APN	7	16,892,115 (GRCm39)	missense	probably damaging	1.00
IGL03143:Ceacam3	APN	7	16,892,045 (GRCm39)	nonsense	probably null
R0408:Ceacam3	UTSW	7	16,885,808 (GRCm39)	critical splice donor site	probably benign
R0591:Ceacam3	UTSW	7	16,885,808 (GRCm39)	critical splice donor site	probably null
R1274:Ceacam3	UTSW	7	16,897,064 (GRCm39)	missense	probably damaging	0.98
R1376:Ceacam3	UTSW	7	16,897,088 (GRCm39)	missense	probably damaging	1.00
R1376:Ceacam3	UTSW	7	16,897,088 (GRCm39)	missense	probably damaging	1.00
R1490:Ceacam3	UTSW	7	16,897,071 (GRCm39)	missense	probably damaging	1.00
R1635:Ceacam3	UTSW	7	16,893,902 (GRCm39)	missense	probably damaging	1.00
R1769:Ceacam3	UTSW	7	16,892,301 (GRCm39)	missense	probably damaging	1.00
R2345:Ceacam3	UTSW	7	16,888,925 (GRCm39)	missense	possibly damaging	0.79
R2367:Ceacam3	UTSW	7	16,885,813 (GRCm39)	splice site	probably null
R2403:Ceacam3	UTSW	7	16,895,779 (GRCm39)	missense	probably damaging	1.00
R4030:Ceacam3	UTSW	7	16,892,267 (GRCm39)	missense	probably benign	0.43
R4240:Ceacam3	UTSW	7	16,893,949 (GRCm39)	missense	possibly damaging	0.95
R5305:Ceacam3	UTSW	7	16,885,501 (GRCm39)	missense	probably damaging	1.00
R5314:Ceacam3	UTSW	7	16,892,296 (GRCm39)	missense	possibly damaging	0.94
R5433:Ceacam3	UTSW	7	16,893,808 (GRCm39)	missense	possibly damaging	0.48
R5538:Ceacam3	UTSW	7	16,892,346 (GRCm39)	missense	probably damaging	1.00
R5638:Ceacam3	UTSW	7	16,893,860 (GRCm39)	missense	probably damaging	0.98
R5787:Ceacam3	UTSW	7	16,888,971 (GRCm39)	missense	possibly damaging	0.80
R5891:Ceacam3	UTSW	7	16,885,718 (GRCm39)	missense	probably damaging	1.00
R5918:Ceacam3	UTSW	7	16,893,670 (GRCm39)	missense	probably damaging	0.99
R6074:Ceacam3	UTSW	7	16,885,484 (GRCm39)	missense	probably benign	0.05
R6386:Ceacam3	UTSW	7	16,892,144 (GRCm39)	missense	probably benign	0.22
R6439:Ceacam3	UTSW	7	16,892,253 (GRCm39)	missense	possibly damaging	0.59
R6455:Ceacam3	UTSW	7	16,895,863 (GRCm39)	missense	possibly damaging	0.81
R7150:Ceacam3	UTSW	7	16,885,487 (GRCm39)	missense
R7196:Ceacam3	UTSW	7	16,888,881 (GRCm39)	missense
R7201:Ceacam3	UTSW	7	16,892,163 (GRCm39)	nonsense	probably null
R7731:Ceacam3	UTSW	7	16,892,275 (GRCm39)	missense
R7833:Ceacam3	UTSW	7	16,893,778 (GRCm39)	missense
R8202:Ceacam3	UTSW	7	16,896,953 (GRCm39)	missense
R8237:Ceacam3	UTSW	7	16,897,082 (GRCm39)	missense
R8420:Ceacam3	UTSW	7	16,895,608 (GRCm39)	missense
R8696:Ceacam3	UTSW	7	16,893,937 (GRCm39)	missense
R9381:Ceacam3	UTSW	7	16,893,715 (GRCm39)	missense
R9616:Ceacam3	UTSW	7	16,892,078 (GRCm39)	missense
R9633:Ceacam3	UTSW	7	16,895,688 (GRCm39)	missense
R9686:Ceacam3	UTSW	7	16,892,123 (GRCm39)	missense
R9727:Ceacam3	UTSW	7	16,892,262 (GRCm39)	missense

Posted On

2016-08-02