Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03269:Trgv4'

415202

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trgv4

Ensembl Gene

ENSMUSG00000076745

Gene Name

T cell receptor gamma, variable 4

Synonyms

Tcrg-V4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.048) question?

Stock #

IGL03269

Quality Score

Status

Chromosome

Chromosomal Location

19369151-19369676 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 19369622 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 122 (I122K)

Ref Sequence

ENSEMBL: ENSMUSP00000100335 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103554] [ENSMUST00000103555] [ENSMUST00000198330]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000103554
AA Change: I122K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000100335
Gene: ENSMUSG00000076745
AA Change: I122K

Domain	Start	End	E-Value	Type
IGv	57	137	5.79e-9	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000103555

SMART Domains

Protein: ENSMUSP00000100336
Gene: ENSMUSG00000076746

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
IG	40	134	2.94e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000197661

Predicted Effect

probably benign
Transcript: ENSMUST00000198330

SMART Domains

Protein: ENSMUSP00000142811
Gene: ENSMUSG00000076746

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
IG	27	121	1.2e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl2	T	A	2: 26,998,367 (GRCm39)	C930*	probably null	Het
Ankar	A	T	1: 72,704,360 (GRCm39)	V854E	probably damaging	Het
Ceacam3	T	A	7: 16,895,767 (GRCm39)	L579Q	probably damaging	Het
Clip2	G	T	5: 134,545,748 (GRCm39)	H314Q	probably damaging	Het
Fbxo28	A	G	1: 182,144,583 (GRCm39)	V327A	possibly damaging	Het
Gdap1	T	A	1: 17,231,729 (GRCm39)	F358Y	probably benign	Het
Ift70a2	T	C	2: 75,808,479 (GRCm39)	D11G	possibly damaging	Het
Ighv1-18	T	C	12: 114,646,466 (GRCm39)	Y46C	probably damaging	Het
Il1rl2	T	A	1: 40,404,472 (GRCm39)	F531Y	probably damaging	Het
Irf6	A	G	1: 192,844,906 (GRCm39)		probably benign	Het
Ncoa6	T	C	2: 155,248,409 (GRCm39)	T1632A	probably damaging	Het
Odad3	A	G	9: 21,909,339 (GRCm39)		probably null	Het
Or4l1	T	A	14: 50,166,165 (GRCm39)	T279S	probably damaging	Het
Or5b3	T	A	19: 13,388,792 (GRCm39)	N286K	probably damaging	Het
Or8b43	A	G	9: 38,360,197 (GRCm39)	T10A	probably benign	Het
Osgepl1	C	A	1: 53,360,271 (GRCm39)	Y332*	probably null	Het
Pibf1	G	A	14: 99,425,171 (GRCm39)	A553T	probably damaging	Het
Prpf38b	A	G	3: 108,812,557 (GRCm39)	F219L	probably benign	Het
Pwp1	C	A	10: 85,718,768 (GRCm39)	Q312K	probably damaging	Het
Rnf17	T	C	14: 56,665,403 (GRCm39)	V185A	possibly damaging	Het
Serpina3k	T	C	12: 104,306,780 (GRCm39)	I4T	possibly damaging	Het
Slc33a1	A	G	3: 63,871,178 (GRCm39)	V145A	probably damaging	Het
Slco3a1	T	C	7: 73,968,280 (GRCm39)	D480G	possibly damaging	Het
Tdpoz4	G	A	3: 93,704,144 (GRCm39)	C147Y	probably damaging	Het
Tlr4	C	A	4: 66,759,033 (GRCm39)	P609T	probably damaging	Het
Unc79	A	G	12: 103,054,936 (GRCm39)	K927E	probably damaging	Het
Vmn1r71	G	A	7: 10,482,571 (GRCm39)	T39I	possibly damaging	Het
Vmn2r9	A	G	5: 108,995,820 (GRCm39)	L276P	probably damaging	Het
Zfp335	C	A	2: 164,742,274 (GRCm39)	R570L	probably damaging	Het

Other mutations in Trgv4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01569:Trgv4	APN	13	19,369,678 (GRCm39)	unclassified	probably benign
IGL02821:Trgv4	APN	13	19,369,422 (GRCm39)	missense	possibly damaging	0.60
R0102:Trgv4	UTSW	13	19,369,370 (GRCm39)	missense	possibly damaging	0.74
R0104:Trgv4	UTSW	13	19,369,480 (GRCm39)	missense	probably damaging	1.00
R4369:Trgv4	UTSW	13	19,369,567 (GRCm39)	missense	probably benign	0.06
R4856:Trgv4	UTSW	13	19,369,236 (GRCm39)	missense	probably benign	0.01
R4886:Trgv4	UTSW	13	19,369,236 (GRCm39)	missense	probably benign	0.01
R6575:Trgv4	UTSW	13	19,369,250 (GRCm39)	missense	probably benign	0.03
R8894:Trgv4	UTSW	13	19,369,627 (GRCm39)	missense	probably damaging	1.00
R9031:Trgv4	UTSW	13	19,369,169 (GRCm39)	nonsense	probably null

Posted On

2016-08-02