Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03270:Vmn2r110'

415224

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r110

Ensembl Gene

ENSMUSG00000091259

Gene Name

vomeronasal 2, receptor 110

Synonyms

EG224582

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.211) question?

Stock #

IGL03270

Quality Score

Status

Chromosome

Chromosomal Location

20794091-20816521 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 20803778 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 266 (M266L)

Ref Sequence

ENSEMBL: ENSMUSP00000129347 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169559]

AlphaFold

E9PWD5

Predicted Effect

probably benign
Transcript: ENSMUST00000169559
AA Change: M266L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000129347
Gene: ENSMUSG00000091259
AA Change: M266L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	3.1e-33	PFAM
Pfam:NCD3G	510	563	5.2e-22	PFAM
Pfam:7tm_3	594	831	4.2e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ctnnd1	A	T	2: 84,440,071 (GRCm39)		probably null	Het
Fcmr	A	T	1: 130,803,779 (GRCm39)	R194S	possibly damaging	Het
Fmo2	A	G	1: 162,709,595 (GRCm39)	F264S	probably damaging	Het
Gfra2	A	G	14: 71,163,344 (GRCm39)	D209G	possibly damaging	Het
Hsd17b7	C	T	1: 169,780,649 (GRCm39)	E320K	probably damaging	Het
Iigp1c	A	G	18: 60,378,548 (GRCm39)	K28E	probably benign	Het
Kifap3	T	A	1: 163,676,302 (GRCm39)	M419K	probably benign	Het
Lgr6	A	C	1: 134,925,442 (GRCm39)	I133S	probably damaging	Het
Med13l	A	C	5: 118,869,495 (GRCm39)	N811T	probably damaging	Het
Or4c118	A	G	2: 88,975,089 (GRCm39)	F93L	probably damaging	Het
Or6k2	T	A	1: 173,987,119 (GRCm39)	M260K	probably benign	Het
Pappa2	T	A	1: 158,592,637 (GRCm39)	D1580V	possibly damaging	Het
Ppp4r2	T	G	6: 100,840,086 (GRCm39)	N72K	probably damaging	Het
Prr27	T	C	5: 87,983,537 (GRCm39)		probably benign	Het
Rad51d	A	G	11: 82,772,420 (GRCm39)		probably benign	Het
Rel	T	C	11: 23,692,584 (GRCm39)	N483S	probably benign	Het
Scn9a	A	G	2: 66,314,358 (GRCm39)	F1776L	probably damaging	Het
Slco5a1	G	A	1: 12,942,252 (GRCm39)	T798I	probably benign	Het
Ttn	T	C	2: 76,606,811 (GRCm39)	D18033G	probably damaging	Het
Vmn1r46	T	A	6: 89,953,756 (GRCm39)	S202T	probably damaging	Het
Vmn2r26	A	T	6: 124,027,778 (GRCm39)	D506V	probably benign	Het
Zbtb1	T	C	12: 76,432,289 (GRCm39)	S92P	possibly damaging	Het

Other mutations in Vmn2r110

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01774:Vmn2r110	APN	17	20,803,889 (GRCm39)	missense	probably benign	0.01
IGL01824:Vmn2r110	APN	17	20,794,929 (GRCm39)	missense	probably benign	0.44
IGL01879:Vmn2r110	APN	17	20,794,122 (GRCm39)	missense	probably benign	0.01
IGL02168:Vmn2r110	APN	17	20,804,062 (GRCm39)	splice site	probably benign
IGL02178:Vmn2r110	APN	17	20,804,706 (GRCm39)	splice site	probably null
IGL02322:Vmn2r110	APN	17	20,794,197 (GRCm39)	missense	probably damaging	1.00
IGL02323:Vmn2r110	APN	17	20,816,399 (GRCm39)	missense	probably damaging	0.98
IGL02415:Vmn2r110	APN	17	20,804,033 (GRCm39)	missense	probably benign	0.03
IGL02491:Vmn2r110	APN	17	20,816,400 (GRCm39)	missense	probably damaging	0.99
IGL02876:Vmn2r110	APN	17	20,794,558 (GRCm39)	missense	probably damaging	0.98
IGL03141:Vmn2r110	APN	17	20,803,976 (GRCm39)	missense	possibly damaging	0.79
IGL03286:Vmn2r110	APN	17	20,804,468 (GRCm39)	missense	possibly damaging	0.95
IGL03379:Vmn2r110	APN	17	20,803,906 (GRCm39)	missense	probably damaging	0.99
PIT4243001:Vmn2r110	UTSW	17	20,802,379 (GRCm39)	missense	probably benign	0.01
R0040:Vmn2r110	UTSW	17	20,816,346 (GRCm39)	missense	probably benign	0.10
R0195:Vmn2r110	UTSW	17	20,794,317 (GRCm39)	missense	probably benign	0.31
R0716:Vmn2r110	UTSW	17	20,794,165 (GRCm39)	missense	probably damaging	0.99
R1199:Vmn2r110	UTSW	17	20,803,525 (GRCm39)	missense	probably benign	0.03
R1767:Vmn2r110	UTSW	17	20,800,840 (GRCm39)	missense	possibly damaging	0.83
R2212:Vmn2r110	UTSW	17	20,794,209 (GRCm39)	splice site	probably null
R3056:Vmn2r110	UTSW	17	20,803,360 (GRCm39)	missense	probably damaging	1.00
R4093:Vmn2r110	UTSW	17	20,803,642 (GRCm39)	missense	possibly damaging	0.83
R4418:Vmn2r110	UTSW	17	20,803,951 (GRCm39)	nonsense	probably null
R4598:Vmn2r110	UTSW	17	20,804,029 (GRCm39)	nonsense	probably null
R4754:Vmn2r110	UTSW	17	20,816,458 (GRCm39)	missense	probably benign	0.00
R5283:Vmn2r110	UTSW	17	20,800,899 (GRCm39)	missense	probably benign	0.00
R5421:Vmn2r110	UTSW	17	20,803,882 (GRCm39)	missense	probably damaging	1.00
R5672:Vmn2r110	UTSW	17	20,816,494 (GRCm39)	missense	probably benign
R5865:Vmn2r110	UTSW	17	20,804,557 (GRCm39)	missense	probably benign	0.00
R6642:Vmn2r110	UTSW	17	20,803,779 (GRCm39)	missense	possibly damaging	0.94
R6799:Vmn2r110	UTSW	17	20,803,798 (GRCm39)	missense	probably benign
R7167:Vmn2r110	UTSW	17	20,794,441 (GRCm39)	missense	probably benign	0.01
R7291:Vmn2r110	UTSW	17	20,794,471 (GRCm39)	missense	probably benign	0.13
R7320:Vmn2r110	UTSW	17	20,816,316 (GRCm39)	missense	probably benign
R7519:Vmn2r110	UTSW	17	20,804,524 (GRCm39)	missense	probably benign
R8089:Vmn2r110	UTSW	17	20,803,807 (GRCm39)	missense	probably benign	0.00
R8234:Vmn2r110	UTSW	17	20,804,691 (GRCm39)	missense	probably benign	0.12
R8272:Vmn2r110	UTSW	17	20,816,490 (GRCm39)	missense	probably damaging	0.97
R8307:Vmn2r110	UTSW	17	20,803,319 (GRCm39)	missense	probably benign	0.00
R8506:Vmn2r110	UTSW	17	20,804,627 (GRCm39)	missense	probably benign	0.00
R8516:Vmn2r110	UTSW	17	20,794,875 (GRCm39)	missense	probably damaging	1.00
R8555:Vmn2r110	UTSW	17	20,804,618 (GRCm39)	missense	probably damaging	0.97
R8691:Vmn2r110	UTSW	17	20,803,404 (GRCm39)	missense	probably benign	0.19
R8859:Vmn2r110	UTSW	17	20,794,560 (GRCm39)	missense	probably damaging	0.99
R8935:Vmn2r110	UTSW	17	20,803,957 (GRCm39)	missense	probably benign	0.40
R8986:Vmn2r110	UTSW	17	20,803,823 (GRCm39)	missense	probably damaging	0.97
R9012:Vmn2r110	UTSW	17	20,803,627 (GRCm39)	missense	probably damaging	1.00
R9101:Vmn2r110	UTSW	17	20,794,471 (GRCm39)	missense
R9744:Vmn2r110	UTSW	17	20,794,848 (GRCm39)	missense	probably damaging	0.98
R9803:Vmn2r110	UTSW	17	20,803,730 (GRCm39)	missense	probably benign	0.00
Z1088:Vmn2r110	UTSW	17	20,803,942 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02