Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03271:Scgb2b7'

415244

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scgb2b7

Ensembl Gene

ENSMUSG00000094053

Gene Name

secretoglobin, family 2B, member 7

Synonyms

Gm4684, Abpbg7

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL03271

Quality Score

Status

Chromosome

Chromosomal Location

31403204-31405179 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 31404506 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 65 (C65S)

Ref Sequence

ENSEMBL: ENSMUSP00000136731 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000178258]

AlphaFold

D3YYY1

Predicted Effect

probably damaging
Transcript: ENSMUST00000178258
AA Change: C65S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000136731
Gene: ENSMUSG00000094053
AA Change: C65S

Domain	Start	End	E-Value	Type
low complexity region	3	16	N/A	INTRINSIC
Pfam:Feld-I_B	24	90	7.8e-33	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188968

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actbl2	G	T	13: 111,392,408 (GRCm39)	V248L	probably benign	Het
Actl6b	T	A	5: 137,564,246 (GRCm39)	I256N	probably damaging	Het
Agl	G	T	3: 116,572,776 (GRCm39)	T825K	probably benign	Het
Arid5b	A	T	10: 67,933,287 (GRCm39)	S629T	possibly damaging	Het
Atp13a2	T	C	4: 140,727,708 (GRCm39)	I495T	possibly damaging	Het
Bcl6	G	T	16: 23,788,756 (GRCm39)	H537Q	probably benign	Het
Cdh12	A	G	15: 21,586,539 (GRCm39)	E786G	probably benign	Het
Cep290	T	A	10: 100,373,663 (GRCm39)	N1307K	probably benign	Het
Cops3	A	T	11: 59,723,889 (GRCm39)	N89K	probably damaging	Het
Cyp4a29	T	C	4: 115,111,705 (GRCm39)	V494A	probably damaging	Het
Dlg1	A	G	16: 31,676,710 (GRCm39)	H675R	possibly damaging	Het
Dnajc6	T	A	4: 101,365,274 (GRCm39)		probably benign	Het
Dock10	C	A	1: 80,483,126 (GRCm39)	K2107N	probably damaging	Het
Dop1a	T	A	9: 86,386,275 (GRCm39)	L382*	probably null	Het
Faxc	A	C	4: 21,948,757 (GRCm39)	K156N	possibly damaging	Het
Fut2	C	T	7: 45,300,193 (GRCm39)	G193E	possibly damaging	Het
Gapvd1	C	A	2: 34,617,219 (GRCm39)		probably benign	Het
Gfm1	T	C	3: 67,382,076 (GRCm39)	Y717H	probably damaging	Het
Gm4884	A	T	7: 40,692,699 (GRCm39)	T223S	probably benign	Het
Gstm3	C	A	3: 107,873,513 (GRCm39)	V153F	possibly damaging	Het
H2-M10.5	G	T	17: 37,084,243 (GRCm39)	L68F	possibly damaging	Het
Hmcn1	G	T	1: 150,474,175 (GRCm39)	H4756N	possibly damaging	Het
Ift140	C	A	17: 25,306,880 (GRCm39)	R872S	probably damaging	Het
Lars2	T	A	9: 123,288,549 (GRCm39)		probably null	Het
Ltbp4	A	G	7: 27,029,240 (GRCm39)	V149A	unknown	Het
Mpp2	A	T	11: 101,954,249 (GRCm39)		probably benign	Het
Mybbp1a	A	G	11: 72,334,744 (GRCm39)		probably benign	Het
Nxpe4	C	A	9: 48,304,345 (GRCm39)	P144Q	probably damaging	Het
Or13p3	T	A	4: 118,566,982 (GRCm39)	I126N	probably damaging	Het
Or5p6	C	T	7: 107,630,714 (GRCm39)	V279M	probably damaging	Het
Parp4	C	A	14: 56,823,082 (GRCm39)	N67K	probably benign	Het
Pdk1	G	T	2: 71,710,374 (GRCm39)		probably benign	Het
Phip	A	T	9: 82,766,877 (GRCm39)		probably benign	Het
Pls1	A	G	9: 95,658,883 (GRCm39)	S202P	probably benign	Het
Pmpcb	A	G	5: 21,943,874 (GRCm39)	Y36C	probably benign	Het
Pole	T	C	5: 110,466,185 (GRCm39)	S1296P	probably benign	Het
Ptpn13	T	C	5: 103,610,014 (GRCm39)	S4P	probably damaging	Het
Sec61a2	A	T	2: 5,887,745 (GRCm39)	L79*	probably null	Het
Slc2a5	T	C	4: 150,220,040 (GRCm39)	L152P	probably damaging	Het
Smu1	C	T	4: 40,738,408 (GRCm39)	G442D	probably benign	Het
Spag16	T	A	1: 69,892,511 (GRCm39)	N97K	probably benign	Het
Spag6l	C	T	16: 16,598,592 (GRCm39)	D300N	probably damaging	Het
Sult3a1	A	G	10: 33,739,997 (GRCm39)	T19A	probably benign	Het
Ttll6	A	G	11: 96,047,513 (GRCm39)	H704R	probably benign	Het
Uba1	T	A	X: 20,541,956 (GRCm39)	D569E	probably damaging	Het
Umodl1	T	A	17: 31,205,473 (GRCm39)	Y689*	probably null	Het
Unc80	A	G	1: 66,734,762 (GRCm39)		probably benign	Het
Utp15	C	A	13: 98,390,202 (GRCm39)	V282F	probably damaging	Het
Vmn1r184	A	G	7: 25,967,034 (GRCm39)	Y260C	probably benign	Het
Vmn1r69	A	G	7: 10,314,596 (GRCm39)	V45A	probably benign	Het
Vmn2r4	C	A	3: 64,305,850 (GRCm39)	R524L	probably benign	Het

Other mutations in Scgb2b7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01994:Scgb2b7	APN	7	31,403,409 (GRCm39)	missense	probably benign	0.26
IGL03242:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03252:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03261:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03277:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03280:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03302:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03308:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03388:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03401:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03402:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
IGL03411:Scgb2b7	APN	7	31,404,506 (GRCm39)	missense	probably damaging	1.00
R0457:Scgb2b7	UTSW	7	31,403,437 (GRCm39)	missense	possibly damaging	0.85
R7741:Scgb2b7	UTSW	7	31,404,454 (GRCm39)	critical splice donor site	probably null
R8925:Scgb2b7	UTSW	7	31,404,602 (GRCm39)	missense	probably benign	0.00
R8927:Scgb2b7	UTSW	7	31,404,602 (GRCm39)	missense	probably benign	0.00
R9801:Scgb2b7	UTSW	7	31,404,580 (GRCm39)	missense	probably damaging	1.00
Z1186:Scgb2b7	UTSW	7	31,404,547 (GRCm39)	missense	probably benign	0.13
Z1186:Scgb2b7	UTSW	7	31,404,489 (GRCm39)	missense	probably benign

Posted On

2016-08-02