Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03272:Ovgp1'

415292

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ovgp1

Ensembl Gene

ENSMUSG00000074340

Gene Name

oviductal glycoprotein 1

Synonyms

Chit5, MOGP, muc9, mucin 9, OGP, oviductin

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03272

Quality Score

Status

Chromosome

Chromosomal Location

105973711-105987423 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 105981325 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 332 (D332E)

Ref Sequence

ENSEMBL: ENSMUSP00000000573 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000573] [ENSMUST00000163626]

Predicted Effect

probably damaging
Transcript: ENSMUST00000000573
AA Change: D332E

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000000573
Gene: ENSMUSG00000074340
AA Change: D332E

Domain	Start	End	E-Value	Type
low complexity region	4	13	N/A	INTRINSIC
Glyco_18	22	360	1.38e-134	SMART
low complexity region	486	515	N/A	INTRINSIC
low complexity region	533	626	N/A	INTRINSIC
low complexity region	637	648	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000092878

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137168

Predicted Effect

probably benign
Transcript: ENSMUST00000163626
AA Change: M221K

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000132424
Gene: ENSMUSG00000074340
AA Change: M221K

Domain	Start	End	E-Value	Type
Glyco_18	9	226	8.52e-21	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000164055

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000167642

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show no phenotypic abnormalities. Female reproduction is essentially normal. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A530099J19Rik	A	T	13: 19,729,537		noncoding transcript	Het
Acp2	C	T	2: 91,204,233		probably benign	Het
B4galnt3	T	C	6: 120,216,306	D413G	probably damaging	Het
Chd2	T	C	7: 73,453,166	D1357G	possibly damaging	Het
Dsg1b	T	C	18: 20,397,389	L367P	probably benign	Het
Emsy	A	T	7: 98,593,762	F1057I	probably damaging	Het
Fam171a2	A	T	11: 102,444,118	F64L	possibly damaging	Het
Fat4	T	C	3: 39,009,703	S4603P	probably benign	Het
Fyco1	T	C	9: 123,829,603	T503A	probably benign	Het
Gpr179	T	C	11: 97,336,593	T1579A	possibly damaging	Het
Itgae	T	C	11: 73,133,854		probably null	Het
Lrriq3	A	T	3: 155,101,058	I115F	probably damaging	Het
Mmrn1	A	G	6: 60,988,435	D1149G	probably damaging	Het
Mylk	A	C	16: 34,979,189	K1650Q	probably benign	Het
Nrap	T	C	19: 56,345,568		probably benign	Het
Olfr193	A	C	16: 59,110,556	V18G	probably benign	Het
Pou2f1	A	T	1: 165,896,480	I296K	possibly damaging	Het
Psd4	A	G	2: 24,405,680		probably benign	Het
Satb2	T	C	1: 56,845,643	Q433R	probably damaging	Het
Serpinb9f	A	T	13: 33,327,916	N134I	probably damaging	Het
Slc6a3	A	G	13: 73,540,929	N124S	probably damaging	Het
Spta1	A	G	1: 174,214,144	N1360S	probably benign	Het
Strc	G	A	2: 121,371,751	T1212I	probably damaging	Het
Tmtc3	T	C	10: 100,457,080	K472R	probably benign	Het

Other mutations in Ovgp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00973:Ovgp1	APN	3	105981277	nonsense	probably null
IGL01152:Ovgp1	APN	3	105986172	missense	possibly damaging	0.94
IGL01458:Ovgp1	APN	3	105974991	missense	probably benign	0.01
IGL01646:Ovgp1	APN	3	105978349	missense	probably damaging	1.00
IGL01768:Ovgp1	APN	3	105981351	critical splice donor site	probably null
IGL02712:Ovgp1	APN	3	105986513	unclassified	probably benign
IGL03065:Ovgp1	APN	3	105986366	missense	probably benign	0.01
IGL03140:Ovgp1	APN	3	105979906	missense	probably damaging	1.00
PIT4472001:Ovgp1	UTSW	3	105986990	missense	unknown
R0277:Ovgp1	UTSW	3	105979892	intron	probably benign
R0560:Ovgp1	UTSW	3	105986410	unclassified	probably benign
R0718:Ovgp1	UTSW	3	105974830	splice site	probably benign
R0743:Ovgp1	UTSW	3	105974932	missense	probably damaging	1.00
R1362:Ovgp1	UTSW	3	105986575	unclassified	probably benign
R1556:Ovgp1	UTSW	3	105986752	unclassified	probably benign
R1776:Ovgp1	UTSW	3	105977798	missense	possibly damaging	0.52
R1831:Ovgp1	UTSW	3	105985068	missense	probably benign	0.04
R1986:Ovgp1	UTSW	3	105974935	missense	probably damaging	1.00
R2004:Ovgp1	UTSW	3	105986993	unclassified	probably benign
R2156:Ovgp1	UTSW	3	105977717	missense	possibly damaging	0.49
R2254:Ovgp1	UTSW	3	105986912	unclassified	probably benign
R2860:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R2861:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R3117:Ovgp1	UTSW	3	105986452	unclassified	probably benign
R3793:Ovgp1	UTSW	3	105980171	missense	probably benign	0.03
R3835:Ovgp1	UTSW	3	105986315	missense	probably benign	0.00
R3894:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R3894:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R3895:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R4467:Ovgp1	UTSW	3	105977711	missense	probably benign	0.04
R4611:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R4628:Ovgp1	UTSW	3	105980323	splice site	probably null
R4738:Ovgp1	UTSW	3	105979918	missense	probably damaging	1.00
R4944:Ovgp1	UTSW	3	105979953	missense	possibly damaging	0.66
R5110:Ovgp1	UTSW	3	105977783	missense	probably damaging	1.00
R6531:Ovgp1	UTSW	3	105987071	unclassified	probably benign
R6540:Ovgp1	UTSW	3	105986581	nonsense	probably null
R6562:Ovgp1	UTSW	3	105980273	missense	probably damaging	1.00
R6601:Ovgp1	UTSW	3	105986431	unclassified	probably benign
R6906:Ovgp1	UTSW	3	105986873	unclassified	probably benign
R7313:Ovgp1	UTSW	3	105987071	missense	unknown
R7430:Ovgp1	UTSW	3	105986302	missense	probably damaging	0.99
R7430:Ovgp1	UTSW	3	105986303	missense	possibly damaging	0.62
R7566:Ovgp1	UTSW	3	105974310	start gained	probably benign
R7684:Ovgp1	UTSW	3	105979956	missense	probably damaging	0.99
R7805:Ovgp1	UTSW	3	105986794	missense	unknown
R7820:Ovgp1	UTSW	3	105986521	unclassified	probably benign
R7919:Ovgp1	UTSW	3	105981285	missense	probably damaging	1.00
R8039:Ovgp1	UTSW	3	105976023	missense	probably benign	0.26
R8483:Ovgp1	UTSW	3	105986995	unclassified	probably benign
Z1177:Ovgp1	UTSW	3	105986840	missense	unknown

Posted On

2016-08-02