Incidental Mutation 'IGL03275:Vmn1r228'
ID415377
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r228
Ensembl Gene ENSMUSG00000060245
Gene Namevomeronasal 1 receptor 228
SynonymsV1re3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.075) question?
Stock #IGL03275
Quality Score
Status
Chromosome17
Chromosomal Location20776059-20777501 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 20776842 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 138 (I138T)
Ref Sequence ENSEMBL: ENSMUSP00000072243 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072410]
Predicted Effect probably damaging
Transcript: ENSMUST00000072410
AA Change: I138T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000072243
Gene: ENSMUSG00000060245
AA Change: I138T

DomainStartEndE-ValueType
Pfam:TAS2R 32 317 2.6e-11 PFAM
Pfam:7tm_1 53 316 2.6e-9 PFAM
Pfam:V1R 63 321 1.3e-26 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik T A 8: 72,445,124 L125H probably damaging Het
2210408I21Rik A T 13: 77,298,555 T816S possibly damaging Het
Aspm T A 1: 139,487,295 I1438N probably damaging Het
BC005561 T A 5: 104,518,277 C222S probably benign Het
Bicdl1 A G 5: 115,731,160 Y134H probably damaging Het
Btnl1 A T 17: 34,385,512 K422N probably damaging Het
Ccdc158 T A 5: 92,629,632 I941F probably benign Het
Crnn A G 3: 93,149,418 K504E possibly damaging Het
Csmd1 T A 8: 16,157,092 I1308L probably benign Het
Cwf19l1 T C 19: 44,123,257 M246V probably benign Het
Desi1 T A 15: 82,003,762 I36F probably damaging Het
Foxf2 A G 13: 31,626,531 N151S probably damaging Het
Fryl A G 5: 73,148,033 V35A possibly damaging Het
Gabrg3 T C 7: 56,773,347 Y201C probably damaging Het
Gm11487 T A 4: 73,403,416 R127S possibly damaging Het
Gm813 T C 16: 58,615,756 Y68C probably damaging Het
Grb10 T A 11: 11,933,591 T500S possibly damaging Het
Hsdl2 A G 4: 59,617,747 *371W probably null Het
Irf7 C A 7: 141,265,146 R49L probably damaging Het
Itpr2 T C 6: 146,158,877 probably benign Het
Jam3 T C 9: 27,101,249 T201A probably damaging Het
Mst1 T C 9: 108,084,388 S606P possibly damaging Het
Olfr483 T A 7: 108,103,608 C100S probably damaging Het
Otog A G 7: 46,306,230 E2800G probably damaging Het
Ptpro C T 6: 137,450,006 P292S probably damaging Het
Rab10 A T 12: 3,256,959 Y79N probably damaging Het
Rc3h1 T C 1: 160,959,555 probably null Het
Slc2a3 C T 6: 122,736,742 probably null Het
Sptbn2 T C 19: 4,732,661 Y542H possibly damaging Het
Tas2r110 T C 6: 132,868,098 F31L probably damaging Het
Ttn A G 2: 76,717,344 S32161P probably damaging Het
Ttn A G 2: 76,945,107 S1864P probably damaging Het
Vmn2r10 T A 5: 109,003,377 T124S probably benign Het
Other mutations in Vmn1r228
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01368:Vmn1r228 APN 17 20776512 missense probably benign 0.07
PIT4498001:Vmn1r228 UTSW 17 20776510 missense probably benign 0.00
R0097:Vmn1r228 UTSW 17 20776363 missense probably benign 0.05
R0097:Vmn1r228 UTSW 17 20776363 missense probably benign 0.05
R0270:Vmn1r228 UTSW 17 20776596 missense possibly damaging 0.60
R0279:Vmn1r228 UTSW 17 20776375 missense probably benign 0.02
R1544:Vmn1r228 UTSW 17 20777023 missense probably benign 0.00
R1695:Vmn1r228 UTSW 17 20776298 missense possibly damaging 0.49
R2086:Vmn1r228 UTSW 17 20777193 missense possibly damaging 0.71
R2275:Vmn1r228 UTSW 17 20776545 missense probably damaging 1.00
R2965:Vmn1r228 UTSW 17 20776347 missense probably damaging 0.99
R4425:Vmn1r228 UTSW 17 20776599 missense probably damaging 1.00
R4447:Vmn1r228 UTSW 17 20777107 missense probably damaging 0.96
R5031:Vmn1r228 UTSW 17 20776681 nonsense probably null
R6345:Vmn1r228 UTSW 17 20776882 missense probably damaging 1.00
R7064:Vmn1r228 UTSW 17 20777023 missense probably benign 0.00
R7880:Vmn1r228 UTSW 17 20776410 missense probably damaging 1.00
R7963:Vmn1r228 UTSW 17 20776410 missense probably damaging 1.00
R8000:Vmn1r228 UTSW 17 20776965 missense possibly damaging 0.88
X0018:Vmn1r228 UTSW 17 20776701 missense probably benign 0.08
Posted On2016-08-02