Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03275:Vmn1r228'

415377

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r228

Ensembl Gene

ENSMUSG00000060245

Gene Name

vomeronasal 1 receptor 228

Synonyms

V1re3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL03275

Quality Score

Status

Chromosome

Chromosomal Location

20776059-20777501 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20776842 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 138 (I138T)

Ref Sequence

ENSEMBL: ENSMUSP00000072243 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072410]

AlphaFold

Q8R2A7

Predicted Effect

probably damaging
Transcript: ENSMUST00000072410
AA Change: I138T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000072243
Gene: ENSMUSG00000060245
AA Change: I138T

Domain	Start	End	E-Value	Type
Pfam:TAS2R	32	317	2.6e-11	PFAM
Pfam:7tm_1	53	316	2.6e-9	PFAM
Pfam:V1R	63	321	1.3e-26	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700030K09Rik	T	A	8: 72,445,124	L125H	probably damaging	Het
2210408I21Rik	A	T	13: 77,298,555	T816S	possibly damaging	Het
Aspm	T	A	1: 139,487,295	I1438N	probably damaging	Het
BC005561	T	A	5: 104,518,277	C222S	probably benign	Het
Bicdl1	A	G	5: 115,731,160	Y134H	probably damaging	Het
Btnl1	A	T	17: 34,385,512	K422N	probably damaging	Het
Ccdc158	T	A	5: 92,629,632	I941F	probably benign	Het
Crnn	A	G	3: 93,149,418	K504E	possibly damaging	Het
Csmd1	T	A	8: 16,157,092	I1308L	probably benign	Het
Cwf19l1	T	C	19: 44,123,257	M246V	probably benign	Het
Desi1	T	A	15: 82,003,762	I36F	probably damaging	Het
Foxf2	A	G	13: 31,626,531	N151S	probably damaging	Het
Fryl	A	G	5: 73,148,033	V35A	possibly damaging	Het
Gabrg3	T	C	7: 56,773,347	Y201C	probably damaging	Het
Gm11487	T	A	4: 73,403,416	R127S	possibly damaging	Het
Gm813	T	C	16: 58,615,756	Y68C	probably damaging	Het
Grb10	T	A	11: 11,933,591	T500S	possibly damaging	Het
Hsdl2	A	G	4: 59,617,747	*371W	probably null	Het
Irf7	C	A	7: 141,265,146	R49L	probably damaging	Het
Itpr2	T	C	6: 146,158,877		probably benign	Het
Jam3	T	C	9: 27,101,249	T201A	probably damaging	Het
Mst1	T	C	9: 108,084,388	S606P	possibly damaging	Het
Olfr483	T	A	7: 108,103,608	C100S	probably damaging	Het
Otog	A	G	7: 46,306,230	E2800G	probably damaging	Het
Ptpro	C	T	6: 137,450,006	P292S	probably damaging	Het
Rab10	A	T	12: 3,256,959	Y79N	probably damaging	Het
Rc3h1	T	C	1: 160,959,555		probably null	Het
Slc2a3	C	T	6: 122,736,742		probably null	Het
Sptbn2	T	C	19: 4,732,661	Y542H	possibly damaging	Het
Tas2r110	T	C	6: 132,868,098	F31L	probably damaging	Het
Ttn	A	G	2: 76,717,344	S32161P	probably damaging	Het
Ttn	A	G	2: 76,945,107	S1864P	probably damaging	Het
Vmn2r10	T	A	5: 109,003,377	T124S	probably benign	Het

Other mutations in Vmn1r228

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01368:Vmn1r228	APN	17	20776512	missense	probably benign	0.07
PIT4498001:Vmn1r228	UTSW	17	20776510	missense	probably benign	0.00
R0097:Vmn1r228	UTSW	17	20776363	missense	probably benign	0.05
R0097:Vmn1r228	UTSW	17	20776363	missense	probably benign	0.05
R0270:Vmn1r228	UTSW	17	20776596	missense	possibly damaging	0.60
R0279:Vmn1r228	UTSW	17	20776375	missense	probably benign	0.02
R1544:Vmn1r228	UTSW	17	20777023	missense	probably benign	0.00
R1695:Vmn1r228	UTSW	17	20776298	missense	possibly damaging	0.49
R2086:Vmn1r228	UTSW	17	20777193	missense	possibly damaging	0.71
R2275:Vmn1r228	UTSW	17	20776545	missense	probably damaging	1.00
R2965:Vmn1r228	UTSW	17	20776347	missense	probably damaging	0.99
R4425:Vmn1r228	UTSW	17	20776599	missense	probably damaging	1.00
R4447:Vmn1r228	UTSW	17	20777107	missense	probably damaging	0.96
R5031:Vmn1r228	UTSW	17	20776681	nonsense	probably null
R6345:Vmn1r228	UTSW	17	20776882	missense	probably damaging	1.00
R7064:Vmn1r228	UTSW	17	20777023	missense	probably benign	0.00
R7880:Vmn1r228	UTSW	17	20776410	missense	probably damaging	1.00
R8000:Vmn1r228	UTSW	17	20776965	missense	possibly damaging	0.88
R8290:Vmn1r228	UTSW	17	20776462	missense	probably benign	0.09
R9022:Vmn1r228	UTSW	17	20776516	missense	probably damaging	1.00
R9027:Vmn1r228	UTSW	17	20777160	missense	probably benign	0.01
R9291:Vmn1r228	UTSW	17	20776761	missense	probably benign
R9492:Vmn1r228	UTSW	17	20776600	missense	probably damaging	1.00
R9618:Vmn1r228	UTSW	17	20776783	missense	probably benign	0.00
X0018:Vmn1r228	UTSW	17	20776701	missense	probably benign	0.08

Posted On

2016-08-02