Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03277:Vmn2r32'

415434

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r32

Ensembl Gene

ENSMUSG00000096743

Gene Name

vomeronasal 2, receptor 32

Synonyms

V2r5

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.144) question?

Stock #

IGL03277

Quality Score

Status

Chromosome

Chromosomal Location

7463015-7479973 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 7474252 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 380 (D380V)

Ref Sequence

ENSEMBL: ENSMUSP00000092462 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094866]

Predicted Effect

probably benign
Transcript: ENSMUST00000094866
AA Change: D380V

PolyPhen 2 Score 0.233 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000092462
Gene: ENSMUSG00000096743
AA Change: D380V

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	470	3.6e-33	PFAM
Pfam:NCD3G	512	565	8.1e-21	PFAM
Pfam:7tm_3	598	833	9.5e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Amt	A	G	9: 108,301,219	T342A	probably benign	Het
B3glct	T	C	5: 149,726,834	L134P	probably damaging	Het
Bms1	A	T	6: 118,405,122	M485K	probably benign	Het
Chd6	T	C	2: 160,983,061	N1226S	probably null	Het
Cpne2	T	C	8: 94,548,372	Y3H	probably benign	Het
Dmxl2	A	G	9: 54,404,220	V1739A	probably damaging	Het
Dnah7a	T	A	1: 53,630,322	T543S	probably benign	Het
Dock11	T	G	X: 36,013,950	V1000G	probably benign	Het
Ednrb	T	A	14: 103,843,299	N60Y	probably benign	Het
Eif3d	A	G	15: 77,959,649	M499T	possibly damaging	Het
Elmod1	G	A	9: 53,925,988	L178F	probably damaging	Het
Fam214a	G	A	9: 75,009,232	R371Q	probably damaging	Het
Hrh4	T	C	18: 13,015,883	S101P	probably damaging	Het
Ift172	A	G	5: 31,267,298	V684A	possibly damaging	Het
Mtx2	A	G	2: 74,868,404	T124A	probably damaging	Het
Nat3	T	A	8: 67,547,689	H73Q	probably benign	Het
Ndst2	A	G	14: 20,730,166	L2P	possibly damaging	Het
Nipsnap3a	G	T	4: 52,997,219	A162S	probably benign	Het
Olfr1030	T	C	2: 85,984,173	I111T	probably damaging	Het
Olfr47	T	G	6: 43,235,942	C111W	probably damaging	Het
Peg3	T	C	7: 6,711,674	D183G	probably damaging	Het
Prlr	A	G	15: 10,328,801	E454G	probably benign	Het
Prom1	G	A	5: 44,032,971	Q364*	probably null	Het
Scgb2b7	A	T	7: 31,705,081	C65S	probably damaging	Het
Sema5b	A	G	16: 35,651,312	D425G	probably damaging	Het
Slc16a7	A	T	10: 125,230,691	C360S	probably benign	Het
Slc38a7	T	A	8: 95,848,476	I59F	probably damaging	Het
Slc5a6	A	G	5: 31,038,028	C449R	possibly damaging	Het
Slc9b1	T	C	3: 135,390,508	Y357H	possibly damaging	Het
Snx17	A	T	5: 31,195,740		probably benign	Het
Stk32b	A	C	5: 37,628,976	M48R	probably damaging	Het
Tspan9	A	G	6: 127,967,075		probably null	Het
Tst	A	T	15: 78,405,321	N171K	probably damaging	Het
Vmn1r180	T	A	7: 23,953,285	I291N	probably damaging	Het
Wdfy4	T	C	14: 33,068,904	T2189A	probably benign	Het
Zbtb20	A	G	16: 43,618,437	N640S	possibly damaging	Het
Zfp142	A	G	1: 74,571,034	S1098P	probably damaging	Het

Other mutations in Vmn2r32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02140:Vmn2r32	APN	7	7476697	missense	probably damaging	0.97
IGL02333:Vmn2r32	APN	7	7464144	missense	probably damaging	1.00
IGL02406:Vmn2r32	APN	7	7476710	missense	probably benign
IGL02428:Vmn2r32	APN	7	7474284	missense	probably benign	0.02
IGL02484:Vmn2r32	APN	7	7464117	missense	probably damaging	1.00
IGL03366:Vmn2r32	APN	7	7464030	missense	probably damaging	0.99
R1055:Vmn2r32	UTSW	7	7474327	nonsense	probably null
R1695:Vmn2r32	UTSW	7	7463992	missense	probably benign	0.01
R2172:Vmn2r32	UTSW	7	7474615	missense	probably damaging	0.99
R2262:Vmn2r32	UTSW	7	7474619	missense	probably benign
R3150:Vmn2r32	UTSW	7	7472555	missense	probably benign
R4362:Vmn2r32	UTSW	7	7479858	nonsense	probably null
R4432:Vmn2r32	UTSW	7	7479919	missense	probably damaging	0.98
R4851:Vmn2r32	UTSW	7	7479954	missense	possibly damaging	0.59
R4949:Vmn2r32	UTSW	7	7464084	missense	probably benign	0.22
R5990:Vmn2r32	UTSW	7	7479810	missense	probably damaging	0.97
R6083:Vmn2r32	UTSW	7	7464210	missense	probably benign	0.15
R6084:Vmn2r32	UTSW	7	7464210	missense	probably benign	0.15
R6116:Vmn2r32	UTSW	7	7464093	missense	probably damaging	1.00
R6263:Vmn2r32	UTSW	7	7476692	missense	possibly damaging	0.90
R6889:Vmn2r32	UTSW	7	7472574	missense	possibly damaging	0.82
R7286:Vmn2r32	UTSW	7	7479808	missense	probably benign	0.21
R7390:Vmn2r32	UTSW	7	7479852	missense	probably benign	0.00
R7412:Vmn2r32	UTSW	7	7474213	missense	possibly damaging	0.53
R7508:Vmn2r32	UTSW	7	7467374	missense	possibly damaging	0.87
Z1177:Vmn2r32	UTSW	7	7474161	missense	probably damaging	0.98

Posted On

2016-08-02