Incidental Mutation 'IGL03277:Vmn2r32'
| ID |
415434 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r32
|
| Ensembl Gene |
ENSMUSG00000096743 |
| Gene Name |
vomeronasal 2, receptor 32 |
| Synonyms |
V2r5 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.190)
|
| Stock # |
IGL03277
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
7463015-7479973 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 7474252 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 380
(D380V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092462
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094866]
|
| AlphaFold |
K7N686 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094866
AA Change: D380V
PolyPhen 2
Score 0.233 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000092462
Gene: ENSMUSG00000096743
AA Change: D380V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
470 |
3.6e-33 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
8.1e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
9.5e-55 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Amt |
A |
G |
9: 108,301,219 (GRCm38) |
T342A |
probably benign |
Het |
| B3glct |
T |
C |
5: 149,726,834 (GRCm38) |
L134P |
probably damaging |
Het |
| Bms1 |
A |
T |
6: 118,405,122 (GRCm38) |
M485K |
probably benign |
Het |
| Chd6 |
T |
C |
2: 160,983,061 (GRCm38) |
N1226S |
probably null |
Het |
| Cpne2 |
T |
C |
8: 94,548,372 (GRCm38) |
Y3H |
probably benign |
Het |
| Dmxl2 |
A |
G |
9: 54,404,220 (GRCm38) |
V1739A |
probably damaging |
Het |
| Dnah7a |
T |
A |
1: 53,630,322 (GRCm38) |
T543S |
probably benign |
Het |
| Dock11 |
T |
G |
X: 36,013,950 (GRCm38) |
V1000G |
probably benign |
Het |
| Ednrb |
T |
A |
14: 103,843,299 (GRCm38) |
N60Y |
probably benign |
Het |
| Eif3d |
A |
G |
15: 77,959,649 (GRCm38) |
M499T |
possibly damaging |
Het |
| Elmod1 |
G |
A |
9: 53,925,988 (GRCm38) |
L178F |
probably damaging |
Het |
| Fam214a |
G |
A |
9: 75,009,232 (GRCm38) |
R371Q |
probably damaging |
Het |
| Hrh4 |
T |
C |
18: 13,015,883 (GRCm38) |
S101P |
probably damaging |
Het |
| Ift172 |
A |
G |
5: 31,267,298 (GRCm38) |
V684A |
possibly damaging |
Het |
| Mtx2 |
A |
G |
2: 74,868,404 (GRCm38) |
T124A |
probably damaging |
Het |
| Nat3 |
T |
A |
8: 67,547,689 (GRCm38) |
H73Q |
probably benign |
Het |
| Ndst2 |
A |
G |
14: 20,730,166 (GRCm38) |
L2P |
possibly damaging |
Het |
| Nipsnap3a |
G |
T |
4: 52,997,219 (GRCm38) |
A162S |
probably benign |
Het |
| Olfr1030 |
T |
C |
2: 85,984,173 (GRCm38) |
I111T |
probably damaging |
Het |
| Olfr47 |
T |
G |
6: 43,235,942 (GRCm38) |
C111W |
probably damaging |
Het |
| Peg3 |
T |
C |
7: 6,711,674 (GRCm38) |
D183G |
probably damaging |
Het |
| Prlr |
A |
G |
15: 10,328,801 (GRCm38) |
E454G |
probably benign |
Het |
| Prom1 |
G |
A |
5: 44,032,971 (GRCm38) |
Q364* |
probably null |
Het |
| Scgb2b7 |
A |
T |
7: 31,705,081 (GRCm38) |
C65S |
probably damaging |
Het |
| Sema5b |
A |
G |
16: 35,651,312 (GRCm38) |
D425G |
probably damaging |
Het |
| Slc16a7 |
A |
T |
10: 125,230,691 (GRCm38) |
C360S |
probably benign |
Het |
| Slc38a7 |
T |
A |
8: 95,848,476 (GRCm38) |
I59F |
probably damaging |
Het |
| Slc5a6 |
A |
G |
5: 31,038,028 (GRCm38) |
C449R |
possibly damaging |
Het |
| Slc9b1 |
T |
C |
3: 135,390,508 (GRCm38) |
Y357H |
possibly damaging |
Het |
| Snx17 |
A |
T |
5: 31,195,740 (GRCm38) |
|
probably benign |
Het |
| Stk32b |
A |
C |
5: 37,628,976 (GRCm38) |
M48R |
probably damaging |
Het |
| Tspan9 |
A |
G |
6: 127,967,075 (GRCm38) |
|
probably null |
Het |
| Tst |
A |
T |
15: 78,405,321 (GRCm38) |
N171K |
probably damaging |
Het |
| Vmn1r180 |
T |
A |
7: 23,953,285 (GRCm38) |
I291N |
probably damaging |
Het |
| Wdfy4 |
T |
C |
14: 33,068,904 (GRCm38) |
T2189A |
probably benign |
Het |
| Zbtb20 |
A |
G |
16: 43,618,437 (GRCm38) |
N640S |
possibly damaging |
Het |
| Zfp142 |
A |
G |
1: 74,571,034 (GRCm38) |
S1098P |
probably damaging |
Het |
|
| Other mutations in Vmn2r32 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02140:Vmn2r32
|
APN |
7 |
7,476,697 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02333:Vmn2r32
|
APN |
7 |
7,464,144 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02406:Vmn2r32
|
APN |
7 |
7,476,710 (GRCm38) |
missense |
probably benign |
|
|
IGL02428:Vmn2r32
|
APN |
7 |
7,474,284 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL02484:Vmn2r32
|
APN |
7 |
7,464,117 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03366:Vmn2r32
|
APN |
7 |
7,464,030 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1055:Vmn2r32
|
UTSW |
7 |
7,474,327 (GRCm38) |
nonsense |
probably null |
|
|
R1695:Vmn2r32
|
UTSW |
7 |
7,463,992 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2172:Vmn2r32
|
UTSW |
7 |
7,474,615 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2262:Vmn2r32
|
UTSW |
7 |
7,474,619 (GRCm38) |
missense |
probably benign |
|
|
R3150:Vmn2r32
|
UTSW |
7 |
7,472,555 (GRCm38) |
missense |
probably benign |
|
|
R4362:Vmn2r32
|
UTSW |
7 |
7,479,858 (GRCm38) |
nonsense |
probably null |
|
|
R4432:Vmn2r32
|
UTSW |
7 |
7,479,919 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4851:Vmn2r32
|
UTSW |
7 |
7,479,954 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R4949:Vmn2r32
|
UTSW |
7 |
7,464,084 (GRCm38) |
missense |
probably benign |
0.22 |
|
R5990:Vmn2r32
|
UTSW |
7 |
7,479,810 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6083:Vmn2r32
|
UTSW |
7 |
7,464,210 (GRCm38) |
missense |
probably benign |
0.15 |
|
R6084:Vmn2r32
|
UTSW |
7 |
7,464,210 (GRCm38) |
missense |
probably benign |
0.15 |
|
R6116:Vmn2r32
|
UTSW |
7 |
7,464,093 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6263:Vmn2r32
|
UTSW |
7 |
7,476,692 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6889:Vmn2r32
|
UTSW |
7 |
7,472,574 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R7286:Vmn2r32
|
UTSW |
7 |
7,479,808 (GRCm38) |
missense |
probably benign |
0.21 |
|
R7390:Vmn2r32
|
UTSW |
7 |
7,479,852 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7412:Vmn2r32
|
UTSW |
7 |
7,474,213 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R7508:Vmn2r32
|
UTSW |
7 |
7,467,374 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R8812:Vmn2r32
|
UTSW |
7 |
7,474,670 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8968:Vmn2r32
|
UTSW |
7 |
7,474,205 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9331:Vmn2r32
|
UTSW |
7 |
7,464,403 (GRCm38) |
nonsense |
probably null |
|
|
R9358:Vmn2r32
|
UTSW |
7 |
7,474,198 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r32
|
UTSW |
7 |
7,474,161 (GRCm38) |
missense |
probably damaging |
0.98 |
|
| Posted On |
2016-08-02 |
Incidental Mutation