Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03277:Zfp142'

415461

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp142

Ensembl Gene

ENSMUSG00000026135

Gene Name

zinc finger protein 142

Synonyms

9330177B18Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03277

Quality Score

Status

Chromosome

Chromosomal Location

74565127-74588246 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 74571034 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 1098 (S1098P)

Ref Sequence

ENSEMBL: ENSMUSP00000109366 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027315] [ENSMUST00000066986] [ENSMUST00000067916] [ENSMUST00000113737] [ENSMUST00000113749] [ENSMUST00000127921] [ENSMUST00000141412] [ENSMUST00000156613]

AlphaFold

G5E869

Predicted Effect

probably damaging
Transcript: ENSMUST00000027315
AA Change: S1201P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000027315
Gene: ENSMUSG00000026135
AA Change: S1201P

Domain	Start	End	E-Value	Type
ZnF_C2H2	103	127	1.16e1	SMART
ZnF_C2H2	164	186	1.26e-2	SMART
ZnF_C2H2	193	218	7.78e-3	SMART
ZnF_C2H2	223	247	2.29e0	SMART
ZnF_C2H2	250	272	9.96e-1	SMART
low complexity region	317	329	N/A	INTRINSIC
ZnF_C2H2	363	385	9.96e-1	SMART
ZnF_C2H2	391	411	1.26e1	SMART
ZnF_C2H2	419	442	1.47e-3	SMART
ZnF_C2H2	453	475	2.75e-3	SMART
ZnF_C2H2	486	511	3.34e-2	SMART
ZnF_C2H2	516	540	4.81e0	SMART
ZnF_C2H2	543	566	7.05e-1	SMART
ZnF_C2H2	572	595	2.17e-1	SMART
ZnF_C2H2	601	623	1.56e-2	SMART
ZnF_C2H2	629	651	8.94e-3	SMART
ZnF_C2H2	657	679	1.38e-3	SMART
ZnF_C2H2	685	707	9.44e-2	SMART
ZnF_C2H2	712	735	1.26e-2	SMART
ZnF_C2H2	744	767	1.31e0	SMART
ZnF_C2H2	773	796	2.63e0	SMART
low complexity region	903	919	N/A	INTRINSIC
low complexity region	953	969	N/A	INTRINSIC
low complexity region	996	1007	N/A	INTRINSIC
ZnF_C2H2	1039	1059	2.01e1	SMART
ZnF_C2H2	1069	1089	1.91e1	SMART
low complexity region	1147	1160	N/A	INTRINSIC
ZnF_C2H2	1187	1207	2.7e2	SMART
low complexity region	1209	1222	N/A	INTRINSIC
ZnF_C2H2	1265	1285	3.56e1	SMART
ZnF_C2H2	1295	1318	4.98e-1	SMART
ZnF_C2H2	1331	1354	2.49e-1	SMART
ZnF_C2H2	1360	1382	1.03e-2	SMART
ZnF_C2H2	1388	1411	5.72e-1	SMART
ZnF_C2H2	1417	1440	6.75e0	SMART
ZnF_C2H2	1446	1469	9.58e-3	SMART
ZnF_C2H2	1488	1511	1.64e-1	SMART
ZnF_C2H2	1514	1536	1.1e-2	SMART
ZnF_C2H2	1540	1563	4.05e-1	SMART
ZnF_C2H2	1580	1602	4.45e0	SMART
ZnF_C2H2	1608	1630	8.81e-2	SMART
ZnF_C2H2	1636	1658	1.18e-2	SMART
ZnF_C2H2	1664	1686	1.2e-3	SMART
ZnF_C2H2	1692	1715	3.89e-3	SMART
ZnF_C2H2	1721	1743	4.54e-4	SMART
ZnF_C2H2	1749	1771	1.18e-2	SMART
ZnF_C2H2	1777	1799	3.52e-1	SMART
low complexity region	1829	1838	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000066986
AA Change: S1000P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000065149
Gene: ENSMUSG00000026135
AA Change: S1000P

Domain	Start	End	E-Value	Type
low complexity region	116	128	N/A	INTRINSIC
ZnF_C2H2	162	184	9.96e-1	SMART
ZnF_C2H2	190	210	1.26e1	SMART
ZnF_C2H2	218	241	1.47e-3	SMART
ZnF_C2H2	252	274	2.75e-3	SMART
ZnF_C2H2	285	310	3.34e-2	SMART
ZnF_C2H2	315	339	4.81e0	SMART
ZnF_C2H2	342	365	7.05e-1	SMART
ZnF_C2H2	371	394	2.17e-1	SMART
ZnF_C2H2	400	422	1.56e-2	SMART
ZnF_C2H2	428	450	8.94e-3	SMART
ZnF_C2H2	456	478	1.38e-3	SMART
ZnF_C2H2	484	506	9.44e-2	SMART
ZnF_C2H2	511	534	1.26e-2	SMART
ZnF_C2H2	543	566	1.31e0	SMART
ZnF_C2H2	572	595	2.63e0	SMART
low complexity region	702	718	N/A	INTRINSIC
low complexity region	752	768	N/A	INTRINSIC
low complexity region	795	806	N/A	INTRINSIC
ZnF_C2H2	838	858	2.01e1	SMART
ZnF_C2H2	868	888	1.91e1	SMART
low complexity region	946	959	N/A	INTRINSIC
ZnF_C2H2	986	1006	2.7e2	SMART
low complexity region	1008	1021	N/A	INTRINSIC
ZnF_C2H2	1064	1084	3.56e1	SMART
ZnF_C2H2	1094	1117	4.98e-1	SMART
ZnF_C2H2	1130	1153	2.49e-1	SMART
ZnF_C2H2	1159	1181	1.03e-2	SMART
ZnF_C2H2	1187	1210	5.72e-1	SMART
ZnF_C2H2	1216	1239	6.75e0	SMART
ZnF_C2H2	1245	1268	9.58e-3	SMART
ZnF_C2H2	1287	1310	1.64e-1	SMART
ZnF_C2H2	1313	1335	1.1e-2	SMART
ZnF_C2H2	1339	1362	4.05e-1	SMART
ZnF_C2H2	1379	1401	4.45e0	SMART
ZnF_C2H2	1407	1429	8.81e-2	SMART
ZnF_C2H2	1435	1457	1.18e-2	SMART
ZnF_C2H2	1463	1485	1.2e-3	SMART
ZnF_C2H2	1491	1514	3.89e-3	SMART
ZnF_C2H2	1520	1542	4.54e-4	SMART
ZnF_C2H2	1548	1570	1.18e-2	SMART
ZnF_C2H2	1576	1598	3.52e-1	SMART
low complexity region	1628	1637	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000067916

SMART Domains

Protein: ENSMUSP00000064413
Gene: ENSMUSG00000026173

Domain	Start	End	E-Value	Type
PH	17	126	2.6e-12	SMART
EFh	138	166	9.97e-1	SMART
EFh	174	202	1.83e1	SMART
EFh	207	234	4.45e1	SMART
PLCXc	290	435	2.03e-79	SMART
low complexity region	441	459	N/A	INTRINSIC
PLCYc	506	622	1.26e-75	SMART
C2	641	747	5.68e-20	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000113737
AA Change: S1098P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000109366
Gene: ENSMUSG00000026135
AA Change: S1098P

Domain	Start	End	E-Value	Type
ZnF_C2H2	93	115	9.81e1	SMART
ZnF_C2H2	120	144	2.29e0	SMART
ZnF_C2H2	147	169	9.96e-1	SMART
low complexity region	214	226	N/A	INTRINSIC
ZnF_C2H2	260	282	9.96e-1	SMART
ZnF_C2H2	288	308	1.26e1	SMART
ZnF_C2H2	316	339	1.47e-3	SMART
ZnF_C2H2	350	372	2.75e-3	SMART
ZnF_C2H2	383	408	3.34e-2	SMART
ZnF_C2H2	413	437	4.81e0	SMART
ZnF_C2H2	440	463	7.05e-1	SMART
ZnF_C2H2	469	492	2.17e-1	SMART
ZnF_C2H2	498	520	1.56e-2	SMART
ZnF_C2H2	526	548	8.94e-3	SMART
ZnF_C2H2	554	576	1.38e-3	SMART
ZnF_C2H2	582	604	9.44e-2	SMART
ZnF_C2H2	609	632	1.26e-2	SMART
ZnF_C2H2	641	664	1.31e0	SMART
ZnF_C2H2	670	693	2.63e0	SMART
low complexity region	800	816	N/A	INTRINSIC
low complexity region	850	866	N/A	INTRINSIC
low complexity region	893	904	N/A	INTRINSIC
ZnF_C2H2	936	956	2.01e1	SMART
ZnF_C2H2	966	986	1.91e1	SMART
low complexity region	1044	1057	N/A	INTRINSIC
ZnF_C2H2	1084	1104	2.7e2	SMART
low complexity region	1106	1119	N/A	INTRINSIC
ZnF_C2H2	1162	1182	3.56e1	SMART
ZnF_C2H2	1192	1215	4.98e-1	SMART
ZnF_C2H2	1228	1251	2.49e-1	SMART
ZnF_C2H2	1257	1279	1.03e-2	SMART
ZnF_C2H2	1285	1308	5.72e-1	SMART
ZnF_C2H2	1314	1337	6.75e0	SMART
ZnF_C2H2	1343	1366	9.58e-3	SMART
ZnF_C2H2	1385	1408	1.64e-1	SMART
ZnF_C2H2	1411	1433	1.1e-2	SMART
ZnF_C2H2	1437	1460	4.05e-1	SMART
ZnF_C2H2	1477	1499	4.45e0	SMART
ZnF_C2H2	1505	1527	8.81e-2	SMART
ZnF_C2H2	1533	1555	1.18e-2	SMART
ZnF_C2H2	1561	1583	1.2e-3	SMART
ZnF_C2H2	1589	1612	3.89e-3	SMART
ZnF_C2H2	1618	1640	4.54e-4	SMART
ZnF_C2H2	1646	1668	1.18e-2	SMART
ZnF_C2H2	1674	1696	3.52e-1	SMART
low complexity region	1726	1735	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000113749

SMART Domains

Protein: ENSMUSP00000109378
Gene: ENSMUSG00000026173

Domain	Start	End	E-Value	Type
PH	17	126	2.6e-12	SMART
EFh	138	166	9.97e-1	SMART
EFh	174	202	1.83e1	SMART
EFh	207	234	4.45e1	SMART
PLCXc	290	435	2.03e-79	SMART
low complexity region	441	459	N/A	INTRINSIC
PLCYc	538	654	1.26e-75	SMART
C2	673	779	5.68e-20	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000127921

Predicted Effect

probably benign
Transcript: ENSMUST00000141412

SMART Domains

Protein: ENSMUSP00000115322
Gene: ENSMUSG00000026173

Domain	Start	End	E-Value	Type
PH	17	126	2.6e-12	SMART
EFh	138	166	9.97e-1	SMART
EFh	174	202	1.83e1	SMART
EFh	207	234	4.45e1	SMART
PLCXc	290	435	2.03e-79	SMART
low complexity region	441	459	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000156613

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Amt	A	G	9: 108,301,219	T342A	probably benign	Het
B3glct	T	C	5: 149,726,834	L134P	probably damaging	Het
Bms1	A	T	6: 118,405,122	M485K	probably benign	Het
Chd6	T	C	2: 160,983,061	N1226S	probably null	Het
Cpne2	T	C	8: 94,548,372	Y3H	probably benign	Het
Dmxl2	A	G	9: 54,404,220	V1739A	probably damaging	Het
Dnah7a	T	A	1: 53,630,322	T543S	probably benign	Het
Dock11	T	G	X: 36,013,950	V1000G	probably benign	Het
Ednrb	T	A	14: 103,843,299	N60Y	probably benign	Het
Eif3d	A	G	15: 77,959,649	M499T	possibly damaging	Het
Elmod1	G	A	9: 53,925,988	L178F	probably damaging	Het
Fam214a	G	A	9: 75,009,232	R371Q	probably damaging	Het
Hrh4	T	C	18: 13,015,883	S101P	probably damaging	Het
Ift172	A	G	5: 31,267,298	V684A	possibly damaging	Het
Mtx2	A	G	2: 74,868,404	T124A	probably damaging	Het
Nat3	T	A	8: 67,547,689	H73Q	probably benign	Het
Ndst2	A	G	14: 20,730,166	L2P	possibly damaging	Het
Nipsnap3a	G	T	4: 52,997,219	A162S	probably benign	Het
Olfr1030	T	C	2: 85,984,173	I111T	probably damaging	Het
Olfr47	T	G	6: 43,235,942	C111W	probably damaging	Het
Peg3	T	C	7: 6,711,674	D183G	probably damaging	Het
Prlr	A	G	15: 10,328,801	E454G	probably benign	Het
Prom1	G	A	5: 44,032,971	Q364*	probably null	Het
Scgb2b7	A	T	7: 31,705,081	C65S	probably damaging	Het
Sema5b	A	G	16: 35,651,312	D425G	probably damaging	Het
Slc16a7	A	T	10: 125,230,691	C360S	probably benign	Het
Slc38a7	T	A	8: 95,848,476	I59F	probably damaging	Het
Slc5a6	A	G	5: 31,038,028	C449R	possibly damaging	Het
Slc9b1	T	C	3: 135,390,508	Y357H	possibly damaging	Het
Snx17	A	T	5: 31,195,740		probably benign	Het
Stk32b	A	C	5: 37,628,976	M48R	probably damaging	Het
Tspan9	A	G	6: 127,967,075		probably null	Het
Tst	A	T	15: 78,405,321	N171K	probably damaging	Het
Vmn1r180	T	A	7: 23,953,285	I291N	probably damaging	Het
Vmn2r32	T	A	7: 7,474,252	D380V	probably benign	Het
Wdfy4	T	C	14: 33,068,904	T2189A	probably benign	Het
Zbtb20	A	G	16: 43,618,437	N640S	possibly damaging	Het

Other mutations in Zfp142

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00581:Zfp142	APN	1	74566972	missense	probably damaging	1.00
IGL00711:Zfp142	APN	1	74572434	missense	probably damaging	1.00
IGL01391:Zfp142	APN	1	74579540	missense	probably damaging	1.00
IGL01808:Zfp142	APN	1	74576025	missense	probably damaging	1.00
IGL02074:Zfp142	APN	1	74569863	missense	probably damaging	0.97
IGL02134:Zfp142	APN	1	74569863	missense	probably damaging	0.97
IGL02567:Zfp142	APN	1	74578147	missense	possibly damaging	0.84
IGL02567:Zfp142	APN	1	74578149	missense	possibly damaging	0.92
IGL02567:Zfp142	APN	1	74578150	missense	possibly damaging	0.92
IGL02669:Zfp142	APN	1	74571273	missense	probably benign	0.18
IGL02694:Zfp142	APN	1	74570148	missense	probably damaging	0.98
IGL02884:Zfp142	APN	1	74571983	missense	probably damaging	0.99
IGL03000:Zfp142	APN	1	74573618	missense	probably benign	0.01
IGL03080:Zfp142	APN	1	74571209	missense	probably benign	0.18
IGL03238:Zfp142	APN	1	74576278	missense	probably benign	0.37
PIT4402001:Zfp142	UTSW	1	74579528	missense	probably damaging	1.00
R0124:Zfp142	UTSW	1	74568623	missense	probably damaging	1.00
R0256:Zfp142	UTSW	1	74578158	missense	probably benign
R0267:Zfp142	UTSW	1	74576064	missense	probably benign	0.05
R0306:Zfp142	UTSW	1	74570182	missense	probably damaging	1.00
R0321:Zfp142	UTSW	1	74569714	missense	probably damaging	1.00
R0466:Zfp142	UTSW	1	74585411	missense	possibly damaging	0.95
R0513:Zfp142	UTSW	1	74571555	missense	probably damaging	1.00
R1084:Zfp142	UTSW	1	74571826	missense	probably benign
R1534:Zfp142	UTSW	1	74572088	missense	probably benign	0.00
R1548:Zfp142	UTSW	1	74570104	missense	probably damaging	1.00
R1623:Zfp142	UTSW	1	74571775	missense	possibly damaging	0.56
R1628:Zfp142	UTSW	1	74571888	missense	possibly damaging	0.94
R1710:Zfp142	UTSW	1	74572230	missense	probably damaging	1.00
R1722:Zfp142	UTSW	1	74569776	missense	probably damaging	1.00
R1770:Zfp142	UTSW	1	74579631	missense	probably damaging	0.99
R2042:Zfp142	UTSW	1	74570619	missense	probably benign	0.10
R2112:Zfp142	UTSW	1	74573636	missense	probably damaging	1.00
R2249:Zfp142	UTSW	1	74567032	missense	probably damaging	1.00
R4393:Zfp142	UTSW	1	74572060	missense	probably benign	0.00
R4700:Zfp142	UTSW	1	74570272	missense	probably damaging	1.00
R4750:Zfp142	UTSW	1	74572458	missense	probably damaging	1.00
R4763:Zfp142	UTSW	1	74576512	missense	probably damaging	1.00
R5208:Zfp142	UTSW	1	74570868	missense	probably benign	0.18
R5233:Zfp142	UTSW	1	74585449	missense	probably damaging	1.00
R5585:Zfp142	UTSW	1	74578245	nonsense	probably null
R6192:Zfp142	UTSW	1	74570508	missense	probably damaging	1.00
R6461:Zfp142	UTSW	1	74567185	missense	probably damaging	1.00
R6482:Zfp142	UTSW	1	74570217	splice site	probably null
R7320:Zfp142	UTSW	1	74570008	nonsense	probably null
R7438:Zfp142	UTSW	1	74585520	missense	probably benign
R7528:Zfp142	UTSW	1	74570902	missense	probably benign	0.00
R7600:Zfp142	UTSW	1	74573668	missense	probably damaging	1.00
R8007:Zfp142	UTSW	1	74571496	missense	probably benign	0.01
R8681:Zfp142	UTSW	1	74571588	missense	probably damaging	1.00
R8772:Zfp142	UTSW	1	74571666	missense	possibly damaging	0.87
R9058:Zfp142	UTSW	1	74569796	nonsense	probably null
R9233:Zfp142	UTSW	1	74571129	missense	probably benign
R9281:Zfp142	UTSW	1	74568572	missense	probably damaging	1.00
R9302:Zfp142	UTSW	1	74567143	missense	probably damaging	0.98
R9454:Zfp142	UTSW	1	74569857	missense	probably damaging	1.00
Z1177:Zfp142	UTSW	1	74570166	missense	probably damaging	1.00

Posted On

2016-08-02