Incidental Mutation 'IGL03278:Olfr161'
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Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr161
Ensembl Gene ENSMUSG00000051003
Gene Nameolfactory receptor 161
SynonymsMOR131-1, GA_x54KRFPKG5P-112942-113883
Accession Numbers

Genbank: NM_146860; MGI: 3032605

Is this an essential gene? Possibly non essential (E-score: 0.266) question?
Stock #IGL03278
Quality Score
Chromosomal Location3591042-3599323 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 3593107 bp
Amino Acid Change Alanine to Valine at position 237 (A237V)
Ref Sequence ENSEMBL: ENSMUSP00000150825 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061541] [ENSMUST00000216259]
Predicted Effect possibly damaging
Transcript: ENSMUST00000061541
AA Change: A237V

PolyPhen 2 Score 0.554 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000058956
Gene: ENSMUSG00000051003
AA Change: A237V

Pfam:7tm_4 32 308 6.4e-60 PFAM
Pfam:7TM_GPCR_Srsx 36 220 7.2e-6 PFAM
Pfam:7tm_1 42 291 2.9e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216259
AA Change: A237V

PolyPhen 2 Score 0.554 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,158,825 probably benign Het
Acss2 A G 2: 155,562,001 D676G possibly damaging Het
Antxr1 A G 6: 87,204,457 probably benign Het
Ccdc134 C T 15: 82,131,481 A54V possibly damaging Het
Ccdc40 A T 11: 119,242,510 I465F probably damaging Het
Cdk5rap1 A T 2: 154,370,702 S79T probably benign Het
Col6a6 T C 9: 105,709,452 E1790G probably benign Het
Cops8 C A 1: 90,604,365 probably null Het
Dnah7a T C 1: 53,496,965 T2640A probably benign Het
F2 G A 2: 91,635,182 A86V probably benign Het
Fam160a2 C A 7: 105,385,124 M433I possibly damaging Het
Gabrb1 T G 5: 71,869,596 D113E probably damaging Het
Git2 C A 5: 114,745,579 probably benign Het
Git2 A T 5: 114,745,580 probably null Het
Gm4847 A T 1: 166,635,036 I295N probably benign Het
H2-M10.6 C A 17: 36,813,823 H211N probably damaging Het
Hmgcr A G 13: 96,656,762 probably benign Het
Larp1 T C 11: 58,044,056 probably benign Het
Lrguk A G 6: 34,116,446 E634G possibly damaging Het
Nanog A G 6: 122,711,745 Y95C probably damaging Het
Nelfcd G A 2: 174,426,832 A559T possibly damaging Het
Nfe2l1 C A 11: 96,822,192 R55L probably benign Het
Pkmyt1 A G 17: 23,734,247 E259G probably damaging Het
Pld4 A G 12: 112,766,731 N247S probably damaging Het
Prdm4 A T 10: 85,907,758 M211K probably damaging Het
Rab37 A C 11: 115,159,691 I121L possibly damaging Het
Rabl6 T C 2: 25,583,822 probably benign Het
Slc34a3 A T 2: 25,232,047 V154E probably benign Het
Slc38a9 T G 13: 112,689,518 probably benign Het
Sptlc3 G A 2: 139,589,659 G367D probably damaging Het
Stk24 T C 14: 121,302,770 K139R possibly damaging Het
Tacc2 T C 7: 130,733,568 probably null Het
Tap1 A T 17: 34,191,483 K378M probably damaging Het
Tfr2 A T 5: 137,571,036 R10* probably null Het
Trim38 A G 13: 23,790,996 D306G possibly damaging Het
Ttc6 A T 12: 57,622,026 K418I probably damaging Het
Ush2a T A 1: 188,849,116 L3731Q probably damaging Het
Vmn2r89 A T 14: 51,455,100 Y120F probably damaging Het
Vps35 A T 8: 85,294,961 probably benign Het
Other mutations in Olfr161
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Olfr161 APN 16 3592984 missense possibly damaging 0.55
IGL01519:Olfr161 APN 16 3592534 missense probably damaging 1.00
IGL02727:Olfr161 APN 16 3593326 missense probably benign 0.04
F6893:Olfr161 UTSW 16 3593163 missense possibly damaging 0.55
R1634:Olfr161 UTSW 16 3593209 missense probably benign 0.19
R2345:Olfr161 UTSW 16 3593139 missense probably damaging 0.99
R4858:Olfr161 UTSW 16 3592842 missense probably damaging 1.00
R4930:Olfr161 UTSW 16 3592435 missense probably damaging 1.00
R6774:Olfr161 UTSW 16 3592516 missense probably damaging 1.00
R7480:Olfr161 UTSW 16 3592629 missense probably benign 0.03
R7712:Olfr161 UTSW 16 3592431 missense probably damaging 1.00
R8685:Olfr161 UTSW 16 3593040 missense probably damaging 0.99
Z1176:Olfr161 UTSW 16 3592540 missense probably damaging 1.00
Z1176:Olfr161 UTSW 16 3593133 missense probably benign 0.16
Posted On2016-08-02