Incidental Mutation 'IGL03279:Pglyrp3'
ID415518
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pglyrp3
Ensembl Gene ENSMUSG00000042244
Gene Namepeptidoglycan recognition protein 3
SynonymsLOC242100
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.257) question?
Stock #IGL03279
Quality Score
Status
Chromosome3
Chromosomal Location92014583-92031582 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 92026527 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Histidine at position 160 (Y160H)
Ref Sequence ENSEMBL: ENSMUSP00000035737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047660]
Predicted Effect probably damaging
Transcript: ENSMUST00000047660
AA Change: Y160H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035737
Gene: ENSMUSG00000042244
AA Change: Y160H

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
PGRP 28 169 2.64e-45 SMART
Ami_2 39 169 1.06e-2 SMART
PGRP 185 326 3.23e-72 SMART
Ami_2 195 332 1.75e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118636
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk T A 11: 120,013,678 D224V probably damaging Het
Abca4 C A 3: 122,141,732 N1526K probably benign Het
Aif1 T A 17: 35,171,547 K76* probably null Het
Arap2 A G 5: 62,621,910 S1446P probably damaging Het
Cyb5rl A T 4: 107,084,128 E250V possibly damaging Het
Dock3 T C 9: 106,911,248 probably benign Het
Dppa2 A G 16: 48,311,665 T42A possibly damaging Het
Drosha C T 15: 12,859,392 P562L probably benign Het
Egfl7 C A 2: 26,590,707 H126N probably benign Het
Gm5852 T C 3: 93,727,277 noncoding transcript Het
Gpr161 T C 1: 165,310,529 F228S probably damaging Het
Grid1 T A 14: 34,945,765 M83K probably damaging Het
Gsdma2 T C 11: 98,657,723 S434P unknown Het
Hao2 T A 3: 98,880,396 N239I possibly damaging Het
Hsd17b14 A T 7: 45,566,193 I206F possibly damaging Het
Kansl1l A T 1: 66,735,666 V667E probably damaging Het
Kdm3a T C 6: 71,611,675 D450G probably benign Het
Lmo7 C A 14: 101,900,508 A882E probably benign Het
P4ha3 A G 7: 100,300,686 Y254C probably damaging Het
Pcdh15 A G 10: 74,317,072 Y408C probably damaging Het
Pnma5 G A X: 73,035,999 T359I probably benign Het
Ptbp3 A T 4: 59,476,937 H440Q possibly damaging Het
Rbx1 A G 15: 81,468,198 N41S probably damaging Het
Rpl3 G A 15: 80,078,359 T340I probably benign Het
Scrn1 G A 6: 54,548,337 R16* probably null Het
Sema6a A T 18: 47,300,090 C91* probably null Het
Slco6d1 T A 1: 98,466,680 V363E probably damaging Het
Stk38 A G 17: 28,984,205 probably benign Het
Tanc2 G A 11: 105,913,092 probably null Het
Thada A G 17: 84,435,560 F812S probably benign Het
Tubb4b-ps1 A G 5: 7,179,630 probably benign Het
Veph1 T C 3: 66,255,022 T72A probably damaging Het
Vps52 T A 17: 33,957,874 D67E probably damaging Het
Other mutations in Pglyrp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Pglyrp3 APN 3 92022679 missense probably damaging 0.96
IGL00769:Pglyrp3 APN 3 92014622 utr 5 prime probably benign
IGL02491:Pglyrp3 APN 3 92014637 missense possibly damaging 0.77
R0056:Pglyrp3 UTSW 3 92025804 splice site probably benign
R1128:Pglyrp3 UTSW 3 92028172 missense probably benign 0.22
R2097:Pglyrp3 UTSW 3 92028171 missense possibly damaging 0.91
R2140:Pglyrp3 UTSW 3 92026567 missense probably benign 0.00
R3697:Pglyrp3 UTSW 3 92028174 missense probably damaging 1.00
R4369:Pglyrp3 UTSW 3 92028079 missense probably damaging 1.00
R4430:Pglyrp3 UTSW 3 92031491 missense probably damaging 1.00
R4775:Pglyrp3 UTSW 3 92025730 missense possibly damaging 0.64
R6020:Pglyrp3 UTSW 3 92031534 missense probably damaging 1.00
R7352:Pglyrp3 UTSW 3 92014640 nonsense probably null
R7437:Pglyrp3 UTSW 3 92030678 missense probably benign 0.00
R8150:Pglyrp3 UTSW 3 92026483 missense probably benign 0.00
Z1176:Pglyrp3 UTSW 3 92028085 missense probably damaging 1.00
Posted On2016-08-02