Incidental Mutation 'IGL03279:Stk38'
ID415544
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Stk38
Ensembl Gene ENSMUSG00000024006
Gene Nameserine/threonine kinase 38
Synonyms9530097A09Rik, Ndr1, 5830476G13Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.466) question?
Stock #IGL03279
Quality Score
Status
Chromosome17
Chromosomal Location28970885-29007945 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 28984205 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113657 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009138] [ENSMUST00000119274]
Predicted Effect probably benign
Transcript: ENSMUST00000009138
SMART Domains Protein: ENSMUSP00000009138
Gene: ENSMUSG00000024006

DomainStartEndE-ValueType
Blast:S_TKc 31 77 1e-9 BLAST
S_TKc 89 382 1.69e-94 SMART
S_TK_X 383 447 1.23e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000119274
SMART Domains Protein: ENSMUSP00000113657
Gene: ENSMUSG00000024006

DomainStartEndE-ValueType
Blast:S_TKc 31 77 1e-9 BLAST
S_TKc 89 382 1.69e-94 SMART
S_TK_X 383 447 1.23e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125070
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126619
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126893
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129094
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140355
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141431
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142923
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144299
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144516
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection and altered TLR9-activated inflammatory responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk T A 11: 120,013,678 D224V probably damaging Het
Abca4 C A 3: 122,141,732 N1526K probably benign Het
Aif1 T A 17: 35,171,547 K76* probably null Het
Arap2 A G 5: 62,621,910 S1446P probably damaging Het
Cyb5rl A T 4: 107,084,128 E250V possibly damaging Het
Dock3 T C 9: 106,911,248 probably benign Het
Dppa2 A G 16: 48,311,665 T42A possibly damaging Het
Drosha C T 15: 12,859,392 P562L probably benign Het
Egfl7 C A 2: 26,590,707 H126N probably benign Het
Gm5852 T C 3: 93,727,277 noncoding transcript Het
Gpr161 T C 1: 165,310,529 F228S probably damaging Het
Grid1 T A 14: 34,945,765 M83K probably damaging Het
Gsdma2 T C 11: 98,657,723 S434P unknown Het
Hao2 T A 3: 98,880,396 N239I possibly damaging Het
Hsd17b14 A T 7: 45,566,193 I206F possibly damaging Het
Kansl1l A T 1: 66,735,666 V667E probably damaging Het
Kdm3a T C 6: 71,611,675 D450G probably benign Het
Lmo7 C A 14: 101,900,508 A882E probably benign Het
P4ha3 A G 7: 100,300,686 Y254C probably damaging Het
Pcdh15 A G 10: 74,317,072 Y408C probably damaging Het
Pglyrp3 T C 3: 92,026,527 Y160H probably damaging Het
Pnma5 G A X: 73,035,999 T359I probably benign Het
Ptbp3 A T 4: 59,476,937 H440Q possibly damaging Het
Rbx1 A G 15: 81,468,198 N41S probably damaging Het
Rpl3 G A 15: 80,078,359 T340I probably benign Het
Scrn1 G A 6: 54,548,337 R16* probably null Het
Sema6a A T 18: 47,300,090 C91* probably null Het
Slco6d1 T A 1: 98,466,680 V363E probably damaging Het
Tanc2 G A 11: 105,913,092 probably null Het
Thada A G 17: 84,435,560 F812S probably benign Het
Tubb4b-ps1 A G 5: 7,179,630 probably benign Het
Veph1 T C 3: 66,255,022 T72A probably damaging Het
Vps52 T A 17: 33,957,874 D67E probably damaging Het
Other mutations in Stk38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02364:Stk38 APN 17 28991416 missense probably benign
R0029:Stk38 UTSW 17 28982138 missense probably benign 0.00
R0276:Stk38 UTSW 17 28992416 critical splice donor site probably null
R0611:Stk38 UTSW 17 28975933 missense possibly damaging 0.72
R1554:Stk38 UTSW 17 28979232 missense possibly damaging 0.87
R4583:Stk38 UTSW 17 28982156 missense probably damaging 1.00
R5191:Stk38 UTSW 17 28974370 missense probably benign 0.19
R5686:Stk38 UTSW 17 28982129 missense probably damaging 1.00
R6366:Stk38 UTSW 17 28974364 missense probably benign 0.01
R6468:Stk38 UTSW 17 28984112 missense probably benign 0.35
R6830:Stk38 UTSW 17 29000007 critical splice donor site probably null
R7237:Stk38 UTSW 17 28974646 missense possibly damaging 0.49
R8000:Stk38 UTSW 17 28992448 missense probably benign
R8263:Stk38 UTSW 17 28984187 missense probably damaging 1.00
Posted On2016-08-02