Incidental Mutation 'IGL03281:Magea6'
ID 415583
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Magea6
Ensembl Gene ENSMUSG00000063728
Gene Name melanoma antigen, family A, 6
Synonyms Mage-a6
Accession Numbers
Is this an essential gene? Not available question?
Stock # IGL03281
Quality Score
Status
Chromosome X
Chromosomal Location 154924012-154935987 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 154924627 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 144 (C144*)
Ref Sequence ENSEMBL: ENSMUSP00000108181 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076986] [ENSMUST00000112562]
AlphaFold O89010
Predicted Effect probably null
Transcript: ENSMUST00000076986
AA Change: C144*
SMART Domains Protein: ENSMUSP00000076250
Gene: ENSMUSG00000063728
AA Change: C144*

DomainStartEndE-ValueType
Pfam:MAGE_N 5 82 4.9e-8 PFAM
MAGE 103 273 6.77e-101 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112562
AA Change: C144*
SMART Domains Protein: ENSMUSP00000108181
Gene: ENSMUSG00000063728
AA Change: C144*

DomainStartEndE-ValueType
Pfam:MAGE_N 5 84 1.5e-15 PFAM
Pfam:MAGE 103 273 1.5e-52 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik G A 11: 58,880,775 R361H probably benign Het
A830010M20Rik A T 5: 107,503,876 T212S probably benign Het
Abcd2 G T 15: 91,151,673 T663K probably damaging Het
Bud23 C T 5: 135,063,887 R28H probably benign Het
Celsr2 T C 3: 108,412,940 Y852C probably damaging Het
Dll1 C A 17: 15,373,604 R167L probably benign Het
Hmgxb4 A G 8: 75,024,162 T538A probably damaging Het
Hrh4 T C 18: 13,022,469 V355A possibly damaging Het
Hrnr A T 3: 93,322,851 E132V probably benign Het
Ighv7-1 A T 12: 113,896,951 probably benign Het
Kcnu1 A T 8: 25,892,077 Q485L probably null Het
Lrp1b T A 2: 40,725,514 M3626L probably benign Het
Map1a G T 2: 121,305,060 R1881L probably damaging Het
Naip2 T A 13: 100,161,620 Y636F probably damaging Het
Olfr536 T A 7: 140,503,800 I220F probably damaging Het
Olfr791 T A 10: 129,526,403 F59I probably benign Het
Prg4 A G 1: 150,450,088 probably benign Het
Ptpn4 T G 1: 119,659,912 Q900H probably damaging Het
Ralgps1 A G 2: 33,172,416 probably null Het
Rasgrp4 C T 7: 29,146,025 A381V possibly damaging Het
Selenbp1 A T 3: 94,937,310 K93* probably null Het
Skint5 T A 4: 113,667,218 K855N unknown Het
Tssk4 T C 14: 55,650,428 V27A possibly damaging Het
Ttc39a C A 4: 109,433,022 Q310K possibly damaging Het
Utp18 C T 11: 93,875,958 V276I probably damaging Het
Vmn2r45 C A 7: 8,483,604 L228F probably damaging Het
Other mutations in Magea6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02519:Magea6 APN X 154924745 missense probably benign 0.00
R3120:Magea6 UTSW X 154924295 missense probably benign 0.00
Posted On 2016-08-02